Salsolinol is present in the bovine posterior pituitary gland and stimulates the release of prolactin both in vivo and in vitro in ruminants

Hashizume, Takumi; Shida, Rino; Suzuki, Shinichi; Nonaka, Sumie; Yonezawa, Chikako; Yamashita, Tetsuro; Kasuya, Etsuko; Sutoh, Madoka; Olah, Mark E.; Székács, D.; Nagy, György M.

doi:10.1016/j.domaniend.2006.12.003

Cited by 28 publications

(49 citation statements)

References 12 publications

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“…Moreover, [ 3 H]-salsolinol has been shown to bind specifically to the homogenate of the anterior lobe as well as NIL obtained from lactating rats (Toth et al 2001, Homicsko et al 2003. Recently, Hashizume et al (2008) demonstrated that a single i.v. injection of salsolinol significantly and dose-dependently stimulated the release of prolactin in goats, and the intracerebroventricular treatment stimulated prolactin release in calves.…”

Section: Discussionmentioning

confidence: 99%

“…Musshoff et al (2000), studying human brain areas involved in the aetiology of alcoholism and Parkinsonism have also found salsolinol present in the hypothalamus. Also, NIL of the pituitary gland in rats (Toth et al 2001) and more recently the posterior pituitary in bovine (Hashizume et al 2008) have been indicated as the sites of salsolinol detection. However, salsolinol found in bovine pituitary extract seemed to originate from the hypothalamic dopaminergic neuron terminals rather than be synthesized in the gland.…”

Section: Discussionmentioning

confidence: 99%

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Identification of salsolinol in the mediobasal hypothalamus of lactating ewes and its relation to suckling-induced prolactin and GH release

Misztal

Górski²,

Tomaszewska-Zaremba³

et al. 2008

Journal of Endocrinology

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The push-pull perfusions of the infundibular nucleus-median eminence (IN/ME) were made in lactating ewes (nZ7) twice, to identify dopamine (DA)-derived salsolinol and the changes in its extracellular concentration in response to suckling. The perfusate collecting period in every ewe consisted of control non-suckling period, 1000-1230 h (five perfusates), and suckling period, 1230-1500 h (next five perfusates). Simultaneously, blood samples were collected from 1000 to 1500 h at 10-min intervals. The perfusate concentrations of salsolinol and DA were measured by HPLC, and plasma prolactin and GH concentrations were assayed by the RIA. Mean concentrations of salsolinol in perfusates collected from the anterior and posterior parts of the IN/ME (according to post-mortem localization of a perfusion site) increased significantly (P!0 . 05 and P!0 . 001 respectively) during the suckling period, when compared with those noted during the non-suckling period. While no DA was found in the anterior part, only vestigial amounts of DA were found in a few perfusates collected from the posterior part. Salsolinol was not detected in the IN/ME of ewes 10 weeks after weaning (seasonal anoestrus). Mean plasma prolactin and GH concentrations during suckling were significantly (P!0 . 001) higher than those noted during the non-suckling period. In conclusion, our current study reveals that salsolinol is present in the IN/ME of lactating ewes and that its extracellular concentration increases during suckling. Moreover, it supports the role of salsolinol as a neurotransmitter involved in the regulatory process of prolactin secretion at least during lactation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Identification of salsolinol in the mediobasal hypothalamus of lactating ewes and its relation to suckling-induced prolactin and GH release

Misztal

Górski²,

Tomaszewska-Zaremba³

et al. 2008

Journal of Endocrinology

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“…1-MeDIQ was proved to be very potent inhibitor of salsolinolinduced PRL release and blocked PRL release in suckling and stressed lactating rats (Bodnar et al, 2004). Since the stimulatory action of salsolinol on PRL release might occur at the hypothalamic as well as at the pituitary level (Toth et al, 2001(Toth et al, , 2002Hashizume et al, 2008a;Misztal et al, 2008Misztal et al, , 2010bGórski et al, 2010;Hasiec et al, 2012) it is assumed that salsolinol can act indirectly through modulation of the dopaminergic system in the hypothalamus as well as directly through stimulation of specific receptors in pituitary gland. Although exact salsolinol receptors have not been found on prolactin cells the stimulatory effect of salsolinol on PRL release from lactotrophs has been observed in the studies using cell culture systems in rats (Toth et al, 2001) and young 7-8-month old heifers (Hashizume et al, 2008a) but not on 1 month old animals (Hashizume et al, 2009).…”

Section: Factors Stimulating Prolactin Releasementioning

confidence: 99%

Prolactin and the physiological regulation of its secretion. A review

Ciechanowska¹,

Misztal²,

Przekop³

2013

J. Anim. Feed Sci.

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“…As a dopamine derivate, salsolinol has been generally associated with dysfunction of dopaminergic neurons, though presently it is also considered to be a physiological stimulator of PRL release in rodents (Toth et al 2001) and ruminants (Hashizume et al 2008;Misztal et al 2008). In lactating sheep, the suckling stimulus increases the extracellular content of salsolinol in the infundibular nucleus-median eminence, simultaneously with PRL release into the peripheral circulation (Misztal et al 2008).…”

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confidence: 99%

Up-regulation of oxytocin receptor gene and protein in the sheep anterior pituitary by a dopamine derivative (salsolinol)

Górski¹,

Hasiec²,

Zielińska‐Górska³

et al. 2017

CZECH J ANIM SCI

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Górski K., Hasiec M., Zielińska-Górska M., Fülöp F., Misztal T. Specific oxytocin receptors (OTR) have been identified in the anterior pituitary (AP), and their expression has been shown to change in relation to the animal physiological stage, whereas salsolinol (a derivative of dopamine) has been shown to stimulate the synthesis and release of oxytocin (OT) in lactating sheep. In the present study, the expression of both OTR mRNA and OTR protein in the AP were examined by real-time quantitative PCR and enzyme-linked immunosorbent assay, either in anestrous or lactating sheep 48 h after weaning lambs. Moreover, the effect of salsolinol administered via an intracerebroventricular (i.c.v.) infusion was tested in additional sheep at the same physiological stages. The i.c.v. infusions of Ringer-Locke (control) and salsolinol solutions were carried out from 10:00 to 15:00 h in a serial manner, i.e. five 30-min infusions at 30-min intervals. We observed both OTR gene and OTR protein expression in the AP, in both anestrous and lactating sheep, but it was significantly (P < 0.01 and P < 0.05, respectively) higher in the AP of lactating animals compared to anestrous animals. Salsolinol i.c.v. treatment in anestrous sheep evoked a significant (P < 0.05) increase in both OTR gene and OTR protein expression compared to control animals. In contrast, salsolinol did not affect either OTR gene or OTR protein expression in lactating sheep. In conclusion, the expression of OTR in the sheep AP is upregulated by salsolinol. The effect of salsolinol was more pronounced in non-lactating sheep, with a reduced response due to ongoing OTR expression in lactating animals. Increased expression of OTR in the AP of lactating sheep may be related to the stimulation of pituitary lactotrophs by OT following the release of prolactin during suckling.

show abstract

Salsolinol is present in the bovine posterior pituitary gland and stimulates the release of prolactin both in vivo and in vitro in ruminants

Cited by 28 publications

References 12 publications

Identification of salsolinol in the mediobasal hypothalamus of lactating ewes and its relation to suckling-induced prolactin and GH release

Identification of salsolinol in the mediobasal hypothalamus of lactating ewes and its relation to suckling-induced prolactin and GH release

Prolactin and the physiological regulation of its secretion. A review

Up-regulation of oxytocin receptor gene and protein in the sheep anterior pituitary by a dopamine derivative (salsolinol)

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