2000
DOI: 10.1016/s0960-9822(00)00830-7
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Abstract: Genetic analysis of host-pathogen interactions has been hampered by the lack of genetically tractable models of such interactions. We showed previously that the human opportunistic pathogen Pseudomonas aeruginosa kills Caenorhabditis elegans, that P. aeruginosa and C. elegans genes can be identified that affect this killing, and that most of these P. aeruginosa genes are also important for mammalian pathogenesis. Here, we show that Salmonella typhimurium as well as other Salmonella enterica serovars including … Show more

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Cited by 310 publications
(343 citation statements)
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“…We used the method described by Aballay et al (2000), without transfers . Nematodes were incubated at 25ºC for 10 days.…”
Section: Elegans Death Assaymentioning
confidence: 99%
“…We used the method described by Aballay et al (2000), without transfers . Nematodes were incubated at 25ºC for 10 days.…”
Section: Elegans Death Assaymentioning
confidence: 99%
“…Salmonella typhimurium, Serratia marcescens, and Burkholderia pseudomallei, kill the nematode Caenorhabditis elegans when supplied as a food source, and a variety of bacterial virulence factors have been shown to play a role in both nematode and mammalian pathogenesis (1)(2)(3)(4)(5)(6). In addition, C. elegans mutants that are either more susceptible or more resistant to bacterial killing can be readily identified (7,8).…”
Section: S Everal Human Pathogens Including Pseudomonas Aeruginosamentioning
confidence: 99%
“…P. aeruginosa strain PAO1 grown on brain-heart infusion medium kills by a third mechanism involving the generation of one or more neurotoxins (7). A variety of S. enterica serovars, including S. typhimurium, grown on NG medium, kill C. elegans over the course of several days by a mechanism that involves the establishment of a persistent infection in the C. elegans intestine (1).…”
Section: S Everal Human Pathogens Including Pseudomonas Aeruginosamentioning
confidence: 99%
“…Some bacterial pathogens, such as Salmonella enterica serovar Typhimurium are able to establish a persistent infection in the intestine of C. elegans, reducing the life span of the host. Several genes needed for virulence in mammals are also required for pathogenesis in C. elegans (2,10,16,28), implying that the invasion and proliferation of serovar Typhimurium in the host intestine depend on mechanisms common to the nematode and mammals. This makes C. elegans a relevant model for determining the infectivity and fitness of antibiotic-resistant bacteria during a host infection.…”
mentioning
confidence: 99%
“…For example, mutations in the genes fur-1, ompR, or rpoS involved in serovar Typhimurium acid tolerance important for virulence in mammals show attenuated virulence in C. elegans (16). Similarly, the PhoP/Q signal transduction system and several of the genes located in the pathogenicity island 1 are required for virulence in both mammals and C. elegans (2,10). The identification of virulence factors that are important in both mammals and C. elegans can conceivably be explained by conserved interactions with the innate immunity systems (28) and/or similarities in the actual growth environment (e.g., nutrient levels).…”
mentioning
confidence: 99%