2019
DOI: 10.3390/jcm8060840
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Abstract: This study is the first to evaluate oxidative stress biomarkers in saliva/blood of patients with varying degrees of dementia progression. The study included 50 healthy controls and 50 dementia patients divided into two groups: those with mild and moderate dementia (MMSE 11–23) and patients suffering from severe dementia (MMSE 0–10). Cognitive functions of the subjects were assessed using the Mini Mental State Examination (MMSE). Enzymatic and non-enzymatic antioxidants, oxidative damage products and protein gl… Show more

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Cited by 59 publications
(101 citation statements)
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“…Stimulated saliva was collected for 5 min. The secretion of saliva was stimulated by administering 10 µL of 2% citric acid on the tongue every 30 seconds [14]. The volume of saliva was measured with an automated pipette, with an accuracy of 0.1 ml.…”
Section: Sample Collectionmentioning
confidence: 99%
“…Stimulated saliva was collected for 5 min. The secretion of saliva was stimulated by administering 10 µL of 2% citric acid on the tongue every 30 seconds [14]. The volume of saliva was measured with an automated pipette, with an accuracy of 0.1 ml.…”
Section: Sample Collectionmentioning
confidence: 99%
“…It is also worth noting that the composition of saliva reflects dynamic changes in the body, which makes this fluid an excellent tool for determining clinically useful biomarkers [12][13][14][15]. Salivary redox biomarkers are used in the diagnosis of diseases of affluence (obesity, insulin resistance, diabetes, chronic kidney disease) [16][17][18], neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, dementia) [19,20], or cancer (colorectal, breast, ovarian cancer) [21,22]. However, salivary redox homeostasis has not been evaluated yet in patients with chronic heart failure.…”
Section: Introductionmentioning
confidence: 99%
“…Blood elements filtrated into the saliva have attracted much interest in this respect. The study of salivary parameters, in addition to blood, may also reflect a global picture of the body [21]. Moreover, the collection of saliva as a diagnostic material has numerous advantages over peripheral blood, the most important being noninvasive collection, lower anxiety of patients, and greater willingness to monitor one's health [9,21,22].…”
Section: Introductionmentioning
confidence: 99%
“…The study of salivary parameters, in addition to blood, may also reflect a global picture of the body [21]. Moreover, the collection of saliva as a diagnostic material has numerous advantages over peripheral blood, the most important being noninvasive collection, lower anxiety of patients, and greater willingness to monitor one's health [9,21,22]. We demonstrated the usefulness of salivary redox balance biomarkers in the context of several general diseases (systemic sclerosis, insulin resistance, adulthood obesity, diabetes, dementia, and chronic kidney disease); however, there have been no studies to evaluate salivary redox markers and their usefulness in diagnosing psoriasis patients [9,[22][23][24][25].…”
Section: Introductionmentioning
confidence: 99%