Salivary Microbiota for Gastric Cancer Prediction: An Exploratory Study

Huang, Kuo‐Ching; Gao, Xuefeng; Wu, Lili; Yan, Bin; Wang, Zikai; Zhang, Xiaomei; Peng, Lihua; Yu, Jiu-fei; Sun, Gang; Yang, Yunsheng

doi:10.3389/fcimb.2021.640309

Cited by 47 publications

(48 citation statements)

References 57 publications

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“…The general characteristics of the studies examined are summarized in Table 1. Concerning the type of cancers, nine studies (31%) investigated oral microbiota composition in patients with colorectal cancer (CRC) [3,16,[35][36][37][38][39][40][41], seven on pancreatic cancer (PC) [30,[42][43][44][45][46][47], six on gastric cancer (GC) [39,[48][49][50][51][52], five on esophageal cancer (EC) [6,[53][54][55][56], and two on liver cancer (LC) [57,58].…”

Section: Studies Characteristicsmentioning

confidence: 99%

Oral Bacterial Microbiota in Digestive Cancer Patients: A Systematic Review

et al. 2021

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The relation between the gut microbiota and human health is increasingly recognized. Recently, some evidence suggested that dysbiosis of the oral microbiota may be involved in the development of digestive cancers. A systematic review was conducted according to the PRISMA guidelines to investigate the association between the oral microbiota and digestive cancers. Several databases including Medline, Scopus, and Embase were searched by three independent reviewers, without date restriction. Over a total of 1654 records initially identified, 28 studies (2 prospective cohort studies and 26 case-controls) were selected. They investigated oral microbiota composition in patients with esophageal squamous cell carcinoma (n = 5), gastric cancer (n = 5), colorectal cancer (n = 9), liver carcinoma (n = 2), and pancreatic cancer (n = 7). In most of the studies, oral microbiota composition was found to be different between digestive cancer patients and controls. Particularly, oral microbiota dysbiosis and specific bacteria, such as Fusobacterium nucleatum and Porphyromonas gingivalis, appeared to be associated with colorectal cancers. Current evidence suggests that differences exist in oral microbiota composition between patients with and without digestive cancers. Further studies are required to investigate and validate oral–gut microbial transmission patterns and their role in digestive cancer carcinogenesis.

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Section: Studies Characteristicsmentioning

confidence: 99%

Oral Bacterial Microbiota in Digestive Cancer Patients: A Systematic Review

et al. 2021

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“…Some organisms can produce Nnitroso compounds, some of which have been verified to be carcinogens. Several studies have hypothesized that shifts in the microbiome toward organisms capable of producing N-nitroso compounds increase the risk of gastric cancer [72][73][74][75].…”

Section: Differences In Microbiome For Various Diseases Of the Stomachmentioning

confidence: 99%

Impact of Environmental and Pharmacologic Changes on the Upper Gastrointestinal Microbiome

Bilello

Okereke

2021

Biomedicines

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Diseases of the upper gastrointestinal tract have become more prevalent over time. Mechanisms of disease formation are still only partially understood. Recent literature has shown that the surrounding microbiome affects the propensity for disease formation in various parts of the upper gastrointestinal tract. A review was performed of any literature to our best knowledge concerning the effects of pharmacologic agents, environmental changes, and surgical intervention on the microbiome of the upper gastrointestinal tract. Searches of the literature were performed using specific keywords related to drugs, surgical procedures, and environmental factors. Many prescription and nonprescription drugs that are commonly used have varying effects on the upper gastrointestinal tract. Proton pump inhibitors may affect the relative prevalence of some organisms in the lower esophagus and have less effect in the proximal esophagus. Changes in the esophageal microbiome correlate with some esophageal diseases. Drugs that induce weight loss have also been shown to affect the microbiomes of the esophagus and stomach. Common surgical procedures are associated with shifts in the microbial community in the gastrointestinal tract. Environmental factors have been shown to affect the microbiome in the upper gastrointestinal tract, as geographic differences correlate with alterations in the microbiome of the gastrointestinal tract. Understanding the association of environmental and pharmacologic changes on the microbiome of the upper gastrointestinal tract will facilitate treatment plans to reduce morbidity from disease.

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“…According to 2020 global cancer statistics from the International Agency for Research on Cancer (IARC), gastric cancer (GC) is the fifth leading cause of new cases (5.6%) and the fourth leading cause of cancer-related deaths (7.7%) worldwide ( 1 ), and the 5-year survival rate in China is 27.4% ( 2 ). Although the development of diagnostic techniques and alternation of treatment methods have improved the curative effect of on GC the median overall survival (OS) of patients with liver metastasis is only 2 months without systemic chemotherapy ( 3 ).…”

Section: Introductionmentioning

confidence: 99%