Salivary Gland Tumors: Diagnostic Value of Gadolinium-enhanced Dynamic MR Imaging with Histopathologic Correlation

Yabuuchi, Hidetake; Fukuya, Tatsuro; Tajima, Tsuyoshi; Hachitanda, Yoichi; Tomita, Kichinobu; Koga, Mitsuru

doi:10.1148/radiol.2262011486

Cited by 291 publications

(288 citation statements)

References 17 publications

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“…Two patients underwent DCE MRI; the TIC showed a rapidly enhancing and slow washout pattern. According to the classification proposed by Yabuuchi et al [7], the TICs of DCE MRI in our two patients were consistent with the Type II classification (Figure 2e,f).…”

Section: Resultssupporting

confidence: 88%

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Sphenoid sinus ectopic pituitary adenomas: CT and MRI findings

Yang¹,

Chong²,

Wang³

et al. 2010

BJR

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ABSTRACT. Ectopic pituitary adenomas (EPAs) are rare lesions. The purpose of this study was to describe the CT and MRI features of sphenoid sinus EPAs. Eight patients with histology-proven EPAs in the sphenoid sinus, all of whom underwent CT and MRI, were reviewed retrospectively. The following imaging features were analysed: (i) size, (ii) margin, (iii) CT attenuation characteristics and (iv) MRI signal intensity. In addition, the involvement of adjacent structures and the time-intensity curve (TIC) of dynamic contrast-enhanced (DCE) MRI were analysed. All EPAs had well-defined margins and showed no relationship to the intrasellar pituitary gland. The mean size was 28 mm (range, 20-46 mm). On non-enhanced CT, the lesions appeared isodense to grey matter in 7 (88%) patients and hypodense in 1 (12%) patient. Only two patients underwent post-contrast CT, and they showed moderate enhancement. On T 1 weighted images, EPAs appeared isointense in 6 (75%) patients and hypointense in 2 (25%). On T 2 weighted images, the lesions appeared hyperintense in 2 (25%) patients and isointense in 6 (75%). EPAs showed mild to moderate heterogeneous contrast enhancement and exhibited a cribriform-like appearance. Two patients underwent DCE MRI; the TIC showed a rapidly enhancing and slow washout pattern. The following features were also seen: an empty sella, bone changes and involvement of the cavernous sinus (5 patients; 62.5%). In conclusion, a high index of suspicion for EPA and a familiarity with the imaging findings may help to diagnose this rare entity accurately.

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Section: Resultssupporting

confidence: 88%

“…In the present study, we used the classification of the TIC of DCE MRI proposed by Yabuuchi et al [7]: N Type I (steady enhancement pattern) appears as a straight or curved line; enhancement continues over the entire dynamic study.…”

Section: Image Analysismentioning

confidence: 99%

Sphenoid sinus ectopic pituitary adenomas: CT and MRI findings

Yang¹,

Chong²,

Wang³

et al. 2010

BJR

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“…However, further research on the cut-off values for T peak and WR providing maximum accuracy in the differential diagnostics of these three groups produced conflicting results. While there is a consensus with regards to the cut-off values for T peak and WR that accurately distinguish parotid malignancies from Warthin tumours (T peak = 60 s and WR = 30%) [9,18,20,21], the differential diagnostics of pleomorphic adenomas and malignant lesions is still a challenge. Clinical experience suggests that the previously proposed cut-off values for T peak (120, 210 or 240 s) and WR (10%) [9,18,20,21] are not accurate enough to distinguish malignant tumours from pleomorphic adenomas.…”

Section: Discussionmentioning

confidence: 99%

“…The time intensity curves (TICs) for two most common histological types of benign parotid lesions, pleomorphic adenomas and Warthin tumours, differ from those for parotid malignancies [1,[7][8][9][10][11][12][13]19]. A few studies applying this knowledge in differential diagnostics of parotid tumours produced promising results [18,20,21]. However, this evidence, originating from relatively small studies of patients with pleomorphic adenomas, Warthin tumours and parotid malignancies, was not confirmed in routine clinical practice [5].…”

Section: Introductionmentioning

confidence: 99%

An algorithm for preoperative differential diagnostics of parotid tumours on the basis of their dynamic and diffusion-weighted magnetic resonance images: a retrospective analysis of 158 cases

Mikaszewski

Markiet

Smugała³

et al. 2018

Folia Morphol

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“…2). On dynamic MRI, the time-intensity curve indicated an early peak of enhancement and a low washout pattern-categorized as type C by Yabuuchi et al (2003) (Fig. 3).…”

Section: Case Presentationmentioning

confidence: 99%

Chronic Sclerosing Sialadenitis of the Submandibular Gland as the Initial Symptom of IgG4-Related Disease: A Case Report

Tanaka

Harada

Kayamori

et al. 2015

Tohoku J. Exp. Med.

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Immunoglobulin G4-related disease (IgG4-RD) is a systemic condition accompanied by tumefactive lesions, dense lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells, storiform fibrosis in various organs, and, frequently, elevated serum IgG4 levels. Chronic sclerosing sialadenitis (also termed Küttner's tumor) is thought to be a lesion of IgG4-RD; thus, IgG4-related sialadenitis may be the initial symptom of IgG4-RD. We herein report a 64-year-old Japanese female with IgG4-related chronic sclerosing sialadenitis of the right submandibular gland and retroperitoneal fibrosis, who subsequently developed tubulointerstitial nephritis and pancreatitis. She was referred to our Department for treatment of swelling of the right submandibular gland; preoperative imaging studies suggested a malignant tumor. We extirpated the submandibular glands bilaterally and diagnosed IgG4-related chronic sclerosing sialadenitis pathologically. Subsequently, the patient's serum IgG4 concentration increased, and lesions in the retroperitoneum, kidney, and pancreas were confirmed by imaging. Although the radiological characteristics of these lesions mimicked malignancy, steroid treatment was commenced based on the pathology of the submandibular gland and elevated serum IgG4 level. This caused the lesions to disappear, indicating that the patient had experienced IgG4-related retroperitoneal fibrosis, tubulointerstitial nephritis, and pancreatitis. No relapse was detected for 4 years 8 months after surgery. A pathological diagnosis is crucial to exclude the possibility of malignancy and to make treatment decisions when lesions are evident in other organs. In addition, periodic evaluation of the serum IgG4 concentration and imaging of the whole body are warranted in long-term follow-up.

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Salivary Gland Tumors: Diagnostic Value of Gadolinium-enhanced Dynamic MR Imaging with Histopathologic Correlation

Abstract: Gadolinium-enhanced dynamic MR imaging is useful for differentiating benign from malignant salivary gland tumors.

Cited by 291 publications

References 17 publications

Sphenoid sinus ectopic pituitary adenomas: CT and MRI findings

Sphenoid sinus ectopic pituitary adenomas: CT and MRI findings

An algorithm for preoperative differential diagnostics of parotid tumours on the basis of their dynamic and diffusion-weighted magnetic resonance images: a retrospective analysis of 158 cases

Chronic Sclerosing Sialadenitis of the Submandibular Gland as the Initial Symptom of IgG4-Related Disease: A Case Report

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