Salivary gland-sparing helical tomotherapy for head and neck cancer: Preserved salivary function on quantitative salivary gland scintigraphy after tomotherapy

Kreps, S.; Bergès, O.; Belin, Lisa; Zefkili, S.; Petras, Slavomir; Giraud, P.

doi:10.1016/j.anorl.2016.05.003

Cited by 10 publications

(10 citation statements)

References 24 publications

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“…The QUANTEC consortium (6,28) identified a mean parotid gland dose of 26 Gy as a critical threshold for the preservation of salivary function. However, in IMRT clinical practice, it is often challenging to comply with this recommendation, since a detrimental impact on target coverage can't be completely minimized (29). Furthermore, it has been demonstrated that a late recovery of salivary function is feasible, even in cases of overt xerostomia shortly after RT (30).…”

Section: Head and Neck Radiotherapy: Parotid Glandsmentioning

confidence: 99%

Application of Radiomics for the Prediction of Radiation-Induced Toxicity in the IMRT Era: Current State-of-the-Art

et al. 2020

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Normal tissue complication probability (NTCP) models that were formulated in the Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC) are one of the pillars in support of everyday's clinical radiation oncology. Because of steady therapeutic refinements and the availability of cutting-edge technical solutions, the ceiling of organsat-risk-sparing has been reached for photon-based intensity modulated radiotherapy (IMRT). The possibility to capture heterogeneity of patients and tissues in the prediction of toxicity is still an unmet need in modern radiation therapy. Potentially, a major step towards a wider therapeutic index could be obtained from refined assessment of radiation-induced morbidity at an individual level. The rising integration of quantitative imaging and machine learning applications into radiation oncology workflow offers an unprecedented opportunity to further explore the biologic interplay underlying the normal tissue response to radiation. Based on these premises, in this review we focused on the current-state-of-the-art on the use of radiomics for the prediction of toxicity in the field of head and neck, lung, breast and prostate radiotherapy.

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Section: Head and Neck Radiotherapy: Parotid Glandsmentioning

confidence: 99%

Application of Radiomics for the Prediction of Radiation-Induced Toxicity in the IMRT Era: Current State-of-the-Art

et al. 2020

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“…Previous studies have demonstrated that the severity of xerostomia were associated with the hypo-function of the salivary glands due radiation damage, which was found to be dependent on the amount of radiation dose delivered to the glands (16, 17). Because of this, submandibular gland (SMG)-sparing and parotid gland (PG)-sparing techniques have been suggested to minimize the damage of salivary glands in recent studies (18). Several studies including Wang and Eisbruch (19) and Voordeckers et al (20) supported that the mean parotid dose should be kept below 26 Gy for the preservation of salivary gland function.…”

Section: Radiation Induced Damage To Salivary Glandsmentioning

confidence: 99%

A Review on the Assessment of Radiation Induced Salivary Gland Damage After Radiotherapy

Leung

2019

Front. Oncol.

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Head and neck cancers are common in Southern China including Hong Kong. Intensity modulated radiotherapy has been the treatment of choice for these patients. Although radiotherapy provides good local control, radiotherapy treatment side-effects are still inevitable due to close proximity of the organs at risk from the target volume. Xerostomia, which is caused due to the damage of salivary glands, is one of the main radiation induced toxicities in post-radiotherapy head and neck patients. This review article discusses the methods for the assessing of radiation induced salivary gland changes including the gland morphology and saliva flow rate. The discussion also includes the recovery of the salivary gland after radiotherapy and how it is affected by the dose. It is expected that the future direction in monitoring the recovery of salivary glands will focus in cellular or molecular levels, and the development of imaging biomarker.

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“…Z. B. konnte so gezeigt werden, dass die Anwendung der helikalen Tomotherapie, eine besondere Form der intensitätsmodulierten Strahlentherapie (IMRT), bei Kopf-Hals-Tumoren eine präzisere Bestrahlung und somit auch effektivere Schonung der Speicheldrüsen ohne Reduktion der therapeutischen Effektivität ermöglicht [18]. Gegenstand der aktuellen Forschung ist zudem die Xerostomie als Folge einer auf das prostataspezifische Membran-Antigen (PSMA) ausgerichteten Radionuklidtherapie.…”

Section: Indikationen Und Klinische Relevanzunclassified

Sialoszintigrafie

Schmidt-Kreppel

Gaertner

Essler

2020

Der Nuklearmediziner

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ZusammenfassungEine physiologische Funktion der Speicheldrüsen ist wichtig zum Erhalt der Mundschleimhaut, des Geschmackssinns und der Zahngesundheit. Schädigungen können zu einer verminderten oder gar ausbleibenden Speichelbildung führen, was vielfältige Beschwerden zur Folge haben und nicht zuletzt mit einer Einschränkung der Lebensqualität der Betroffenen einhergehen kann. Mit der Sialoszintigrafie ist eine funktionelle simultane Beurteilung der großen Speicheldrüsen mittels einer einzigen kostengünstigen und nicht invasiven Untersuchung möglich. Klinisch relevant ist auch die Möglichkeit der Quantifizierung; Voraussetzung hierfür ist ein standardisiertes Protokoll bei der Durchführung und Auswertung. Aus den vielfältigen Ursachen, die mit einer subjektiv empfundenen Xerostomie einhergehen können, ergeben sich auch die verschiedenen Einsatzbereiche für eine Sialoszintigrafie. Auch aufgrund der in den letzten Jahren zunehmenden Radionuklidtherapien mit PSMA-Liganden besitzt die Speicheldrüsenszintigrafie weiterhin einen hohen klinischen Stellenwert. In der vorliegenden Arbeit wird ein Überblick gegeben über die Durchführung, die Indikationen und den klinischen Stellenwert dieser Untersuchung.

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Salivary gland-sparing helical tomotherapy for head and neck cancer: Preserved salivary function on quantitative salivary gland scintigraphy after tomotherapy

Cited by 10 publications

References 24 publications

Application of Radiomics for the Prediction of Radiation-Induced Toxicity in the IMRT Era: Current State-of-the-Art

Application of Radiomics for the Prediction of Radiation-Induced Toxicity in the IMRT Era: Current State-of-the-Art

A Review on the Assessment of Radiation Induced Salivary Gland Damage After Radiotherapy

Sialoszintigrafie

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