Salivary gland malignant myoepithelioma

Nagao, Toshitaka; Sugano, Isamu; Ishida, Yasuo; Tajima, Yasuo; Matsuzaki, Osamu; Konno, Akiyoshi; Kondō, Yōichirō; Nagao, Kōichi

doi:10.1002/(sici)1097-0142(19981001)83:7<1292::aid-cncr4>3.0.co;2-l

Cited by 257 publications

(69 citation statements)

References 27 publications

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“…1,3,9,13,15,17 Approximately, one third of the patients developed distant metastases, with lung being the most common site. In addition, 4 patients (10%) had LN metastasis at presentation, 9 (27%) developed local recurrences, and 1 died of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…9–11 However, tumors with aggressive histologic features (cytologic atypia, increased mitotic activity, and necrosis) have been reported to occasionally behave in a relatively indolent manner. 9,12,13 To further provide a better characterization of MECA of salivary gland and its prognostic factors, we performed a morphologic analysis of 48 MECAs and correlated the various histopathologic parameters with clinical outcome to establish a grading system that will improve patient outcome stratification.…”

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confidence: 99%

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Prognostic Factors in Myoepithelial Carcinoma of Salivary Glands

Kong¹,

Drill²,

Morris

et al. 2015

American Journal of Surgical Pathology

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Myoepithelial carcinoma (MECA) is an underrecognized rare tumor with a diverse clinical behavior. The histologic features of this tumor are not well characterized, much less its grading, which is controversial. The objective of this study is to provide a better characterization of MECA and its prognostic factors. A total of 48 cases were retrieved from the pathology files. The cases were subjected to a detailed histopathologic, immunohistochemical, statistical, and clinical analysis. Tumors were classified as de novo MECA in 22 cases (46%) and carcinoma ex-pleomorphic adenoma (CA ex-PA) in 26 cases (54%). Tumor necrosis, high mitotic count (≥6/10 high-power fields), and severe pleomorphism were identified in 38%, 33%, and 21%, respectively. Perineural invasion, vascular invasion, and positive margins were noted in 10%, 12%, and 47%, respectively. Median follow-up was 38 months. Four patients had lymph node metastasis at presentation, 9 developed local recurrences, and 12 had distant metastases with the lung being the most common site (83%). The presence of CA ex-PA, necrosis, and vascular invasion correlated significantly with disease-free survival (P = 0.02, 0.01, 0.03, respectively). No distant recurrence was noted in all 23 patients lacking necrosis in their neoplasms (median follow-up: 44 mo). MECA is a relatively aggressive tumor that is associated with a high rate of distant metastasis (27%). Compared with de novo MECA, CA ex-PA correlates with worse clinical outcome. A grading system based on the presence of tumor necrosis should be used to identify high-grade MECA and predict its clinical behavior.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Prognostic Factors in Myoepithelial Carcinoma of Salivary Glands

Kong¹,

Drill²,

Morris

et al. 2015

American Journal of Surgical Pathology

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“…The assessment of cell proliferative activity with the use of the immunohistochemical stain for MiB-1 (Ki-67) (>10%) is a useful aid to distinguish between benign and malignant myoepithelioma as described. [10]…”

Section: Discussionmentioning

confidence: 99%

Fine-needle aspiration findings in epithelioid myoepithelioma of the parotid gland: A diagnostic pitfall

Gayathri

Raju

et al. 2014

J Oral Maxillofac Pathol

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“…Os tipos celulares encontrados são os fusiformes (mais freqüentes nos tumores da parótida), os plasmocitóides (mais freqüentes nos tumores de glândulas salivares menores), e menos freqüentemente, células claras e epitelióides. A arquitetura e o tipo celular não alteram o prognóstico da doença [2][3][4][5] . O principal marcador imuno-histoquímico do mioepitelioma é a proteína S-100, e dificilmente o diagnóstico poderá ser feito se estiver negativo 5 .…”

Section: Discussionunclassified

“…Pode originar-se através da transformação maligna do adenoma pleomórfico e do mioepitelioma. Apesar de ser positivo na pesquisa da proteína S-100, difere-se do mioepitelioma por não ser delimitado, e pela sua alta atividade celular 4 . Embora o adenoma pleomórfico seja o principal diagnóstico diferencial do mioepitelioma tanto clínico quanto histologicamente, outros tumores de base de língua, de origem não mioepitelial, devem ser excluídos.…”

Section: Discussionunclassified

Mioepitelioma de glândula salivar menor em base de língua: relato de caso

T-ping

Pizarro

Pignatari

et al. 2004

Rev. Bras. Otorrinolaringol.

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Os autores apresentam um caso de mioepitelioma de glân-dula salivar menor, localizado na base da língua de uma paciente de 58 anos. O mioepitelioma é um tumor pouco freqüente, de evolução benigna, sendo possível obter-se a cura através da excisão cirúrgica completa da lesão. Neste caso, apresentou-se numa posição bastante incomum, a base da língua. Foi realizada a exérese da lesão, com margens de segurança, e a paciente está assintomática e sem recidiva local depois de 6 meses de acompanhamento pós-operatório. O diagnóstico foi obtido através do estudo anatomopatológico e imuno-histoquímico da peça.

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Salivary gland malignant myoepithelioma

Cited by 257 publications

References 27 publications

Prognostic Factors in Myoepithelial Carcinoma of Salivary Glands

Prognostic Factors in Myoepithelial Carcinoma of Salivary Glands

Fine-needle aspiration findings in epithelioid myoepithelioma of the parotid gland: A diagnostic pitfall

Mioepitelioma de glândula salivar menor em base de língua: relato de caso

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