Salivary gland biopsy: a comprehensive review of techniques and related complications

Colella, Giuseppe; Cannavale, Rosangela; Vicidomini, Antonio; Itro, A

doi:10.1093/rheumatology/keq225

Cited by 58 publications

(39 citation statements)

References 26 publications

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“…The sublingual saliva is predominantly mucus and its contribution to unstimulated and stimulated whole saliva is limited. The most diagnostic alterations in SS regarding salivary flow rates occur in submandibular gland followed by the parotid [7,27]. The results of our studies show that in addition to salivary flow changes, early inflammatory infiltration is seen the submandibular glands of both NOD and IL-14α-TG mouse.…”

Section: Discussionmentioning

confidence: 58%

Temporal histological changes in lacrimal and major salivary glands in mouse models of Sjogren’s syndrome

et al. 2013

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BackgroundEvidence in imaging studies suggests that there may be differences in glandular involvement in Sjogren’s syndrome (SS) depending on the stage of the disease. No detailed histological studies are available to show if there are any such difference in glandular involvement at various time periods and stages of SS. This cross sectional study examines the inflammatory changes in mouse models of SS at various ages.MethodsThe histological changes in major salivary and lacrimal glands were studied at ages of 3, 6, 9, 12, 15 and 18 months in both sexes in well characterized mouse models of SS, non-obese diabetes mouse and Interleukin-14 alpha-transgenic mice.ResultsOur results indicate that early inflammation concurrently occur in submandibular and lacrimal glands around the age of 6 weeks. Parotid glands are involved much later in the course of SS with less severe inflammation. Sublingual glands are rarely involved.ConclusionsOur conclusions are that SS may be an organ specific disease with early inflammation occurring in submandibular and lacrimal glands, followed by the parotid. Non organ specific events occur in later courses of the disease. The understanding of the disease progression is important in tailoring early local therapeutic interventions before complete destruction of salivary and lacrimal glands.

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Section: Discussionmentioning

confidence: 58%

Temporal histological changes in lacrimal and major salivary glands in mouse models of Sjogren’s syndrome

et al. 2013

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“…In clinical practice, combination of clinical findings, serological tests and salivary gland histology has been proposed for diagnosis of pSS. 2,[8][9][10] In April 2012, the American College of Rheumatology approved new classification criteria for SS, this time based only on objective tests. 10 The variability of clinical presentations in patients with pSS may delay the diagnosis after the onset of symptoms.…”

Section: Introductionmentioning

confidence: 99%

Clinical and laboratory profiles of primary Sjogren's syndrome in a Chinese population: A retrospective analysis of 315 patients

et al. 2015

Int J of Rheum Dis

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Aim: To assess the clinical and laboratory features of primary Sjogren's syndrome (pSS) in a large teaching hospital in China.Methods: Three hundred and fifteen pSS patients diagnosed according to American-European Classification Criteria and consecutively admitted to Anhui Provincial Hospital from 1 January 1999 to 30 September 2012 were retrospectively selected in this study. Results:The median age was 46.8 AE 14.4 years (range 13-83 years) and the majority of patients were female (96.5%). The common clinical features at initial presentations were dry mouth (50.2%), dry eyes (31.4%) and joint pain (24.8%); 92.6% of patients had positive anti-SSA antibody and 49.2% patients had positive anti-SSB antibody. One hundred and eighteen patients underwent labial salivary gland biopsy. According to Chisholm grading criteria, grade 3 to 4 was present in 58.5% of the patients. The frequency of interstitial lung disease (ILD) occurred (20.9%) in the patients with systemic extraglandular manifestations. The patients with ILD were frequently associated with positive anti-SSA (P = 0.005) and low levels of C3. The most common impairment of lung function was small airway function abnormalities. Sixty-six pSS patients with ILD (pSS-ILD) were diagnosed with high-resolution computed tomography and treated with corticosteroids and/or immunosuppressants, in which 18 patients had improved pulmonary function.Conclusion: Labial salivary gland biopsy and anti-nuclear antibodies spectrum were important to the diagnosis of pSS. The pSS patients had high percentage of ILD, especially small airway function abnormalities. The combination of corticosteroids and immunosuppressants appears to be effective in treatment of pSS patients with ILD.

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“…Dada la diversidad de criterios utilizados a lo largo de los años y la falta de entrenamiento para la toma de biopsia y lectura del material, sumados a los riesgos menores del procedimiento [8][9][10][11][12][13][14] , determinar en qué casos sería conveniente contar con la histología para definir el diagnóstico de SSp suele plantear inconvenientes en la práctica diaria.…”

Section: Discussionunclassified

“…Si bien este es un procedimiento invasivo, el mismo es de fácil realización y varios estudios mostraron una baja frecuencia de complicaciones, las cuales suelen ser leves [8][9][10][11][12][13][14] .…”

Section: Introductionunclassified

Utilidad de los anticuerpos y de la biopsia de glándula salival menor en el estudio del complejo sicca en la práctica diaria

Santiago¹,

Seisdedos²,

García-Salinas³

et al. 2015

Reumatología Clínica

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Salivary gland biopsy: a comprehensive review of techniques and related complications

Abstract: Biopsy of salivary glands must be performed as last investigation and only when the other items are not complete enough to satisfy the diagnosis. The knowledge of complications and sequelae may be useful in order to minimize the risk.

Cited by 58 publications

References 26 publications

Temporal histological changes in lacrimal and major salivary glands in mouse models of Sjogren’s syndrome

Temporal histological changes in lacrimal and major salivary glands in mouse models of Sjogren’s syndrome

Clinical and laboratory profiles of primary Sjogren's syndrome in a Chinese population: A retrospective analysis of 315 patients

Utilidad de los anticuerpos y de la biopsia de glándula salival menor en el estudio del complejo sicca en la práctica diaria

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