Salivary fetuin‐A, S100A12, and high‐sensitivity C‐reactive protein levels in periodontal diseases

Kalkan, Reyhan Ersin; Dede, Figen Öngöz; Gökmenoğlu, Ceren; Kara, Cankat

doi:10.1111/odi.12927

Cited by 17 publications

(11 citation statements)

References 42 publications

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“…In logistic regression analysis, advanced periodontitis was significantly associated with a low fetuin-A level (OR 1.66) and male sex (OR 2.03). Salivary fetuin-A levels were higher after periodontal treatment than at baseline in a previous study [24]. Future studies should thus examine whether serum or salivary fetuin-A level is a potential biomarker of peri- odontitis.…”

Section: Discussionmentioning

confidence: 73%

Association of low fetuin-A levels with periodontitis in community-dwelling adults

et al. 2020

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Fetuin-A is a liver-secreted glycoprotein isolated from fetal bovine serum. Recent reports of its several pathological functions suggest an association between fetuin-A and systemic diseases. This study therefore examined the correlation between serum fetuin-A level and periodontal status. Data from 356 middle-aged and elderly adults who underwent health examinations in Goto, Japan, during the period from 2008 through 2010 were analyzed. Systemic and periodontal measurements were recorded, and serum fetuin-A level was determined by using an enzyme-linked immunosorbent assay. Fetuin-A levels for participants with moderate to severe periodontitis were significantly lower than those for participants with no or mild periodontitis. Additionally, fetuin-A level negatively correlated with periodontal clinical attachment loss. Moderate to severe periodontitis was significantly correlated with low serum fetuin-A levels (odds ratio, 1.69; 95% confidence interval, 1.01-2.69) in logistic regression analysis. Low serum fetuin-A level was correlated with worse periodontal status and could thus potentially serve as a marker of periodontitis.

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Section: Discussionmentioning

confidence: 73%

Association of low fetuin-A levels with periodontitis in community-dwelling adults

et al. 2020

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“…However, few studies are reporting the role of salivary AHSG in diseases like periodontal disease, obstructive sleep apnea etc. 42,43 . We report here for the first time, upregulated salivary AHSG levels in oral cancer (in comparison to healthy controls).…”

Section: Discussionmentioning

confidence: 99%

Identification of potential salivary biomarker panels for oral squamous cell carcinoma

Jain

Kotimoole

Ghoshal

et al. 2021

Sci Rep

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Oral squamous cell carcinoma (OSCC) is one of the most prevalent cancers worldwide with the maximum number of incidences and deaths reported from India. One of the major causes of poor survival rate associated with OSCC has been attributed to late presentation due to non-availability of a biomarker. Identification of early diagnostic biomarker will help in reducing the disease morbidity and mortality. We validated 12 salivary proteins using targeted proteomics, identified initially by relative quantification of salivary proteins on LC–MS, in OSCC patients and controls. Salivary AHSG (p = 0.0041**) and KRT6C (p = 0.002**) were upregulated in OSCC cases and AZGP1 (p ≤ 0.0001***), KLK1 (p = 0.006**) and BPIFB2 (p = 0.0061**) were downregulated. Regression modelling resulted in a significant risk prediction model (p < 0.0001***) consisting of AZGP1, AHSG and KRT6C for which ROC curve had AUC, sensitivity and specificity of 82.4%, 78% and 73.5% respectively for all OSCC cases and 87.9%, 87.5% and 73.5% respectively for late stage (T3/T4) OSCC. AZGP1, AHSG, KRT6C and BPIFB2 together resulted in ROC curve (p < 0.0001***) with AUC, sensitivity and specificity of 94%, 100% and 77.6% respectively for N0 cases while KRT6C and AZGP1 for N+ cases with ROC curve (p < 0.0001***) having AUC sensitivity and specificity of 76.8%, 73% and 69.4%. Our data aids in the identification of biomarker panels for the diagnosis of OSCC cases with a differential diagnosis between early and late-stage cases.

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“…This association is in accordance several other studies indicating reduced levels of Fetuin A with inflammatory cytokines. 24,33,34,35 Also, previous in vitro study by Schure et al has shown that complete digestion of human Fetuin occurs within 12 hours when it is incubated with a 10fold molar excess of MMP-7. 17 Therefore, MMP-7 is considered to be relevant for the study of pathophysiological degradation of Fetuin A.…”

Section: Figure 2 Comparison Of Serum Fetuin a And Mmp-7 Levels Betwmentioning

confidence: 98%

Correlation of Serum Fetuin A and Matrix Metalloproteinase-7 Levels in Periodontitis and the Outcome of Initial Periodontal Therapy on Their Levels - A Preliminary Report

Lobo¹,

Prabhuji²,

Karthikeyan³

et al. 2019

jemds

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BACKGROUND Fetuin A and MMP7 have been implicated in pathogenesis of the periodontal disease. To date, there is limited evidence that exists on its role in periodontal inflammation. The present study is the first of its kind which is aimed to correlate their concentrations in serum of patients with different periodontal status and explore the impact of periodontal therapy on their levels. METHODS One hundred and twenty, sex matched subjects (60 males and 60 females) belonging to common age group (30-39) were recruited and divided into four groups (n=40) based on clinical and radiographic parameters [PH-Group I;CG-Group-II; CP-Group IIIa; PTCP-Group IIIb (3 months post nonsurgical periodontal therapy)]. Serum samples were collected from each patient, Fetuin A and MMP 7 levels were analysed by enzyme-linked immunosorbent assay. Statistical analysis was performed by parametric and non-parametric tests. RESULTS A significant down regulation of Fetuin A levels (258.7 ng/ml) and concomitant upregulation of MMP-7 levels (256.7 pg/ml) were noted as the periodontal disease progressed (p<0.01). Further, periodontal therapy demonstrated a significant increase in serum Fetuin A and decrease in MMP-7 (37.5 pg/ml) levels (p<0.01). This indicates a negative correlation of Fetuin A and positive correlation of MMP-7 with the extent of periodontal inflammation and establishes the potency of periodontal therapy in stabilizing their levels. CONCLUSIONS Taken together, our data suggests that higher circulatory Fetuin A level has a protective role and helps in maintaining periodontal tissue homeostasis. The reduction of Fetuin A in CP highlights its predictive importance as an antiinflammatory biomarker. Concurrently, it could pose as one of the possible linking factors between inflammatory conditions and vascular calcifications.

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Salivary fetuin‐A, S100A12, and high‐sensitivity C‐reactive protein levels in periodontal diseases

Abstract: Salivary fetuin-A and S100A12 levels decreased with increasing severity of periodontal disease. These results suggest that salivary fetuin-A may play an important role as a negative acute-phase protein in periodontal diseases.

Cited by 17 publications

References 42 publications

Association of low fetuin-A levels with periodontitis in community-dwelling adults

Association of low fetuin-A levels with periodontitis in community-dwelling adults

Identification of potential salivary biomarker panels for oral squamous cell carcinoma

Correlation of Serum Fetuin A and Matrix Metalloproteinase-7 Levels in Periodontitis and the Outcome of Initial Periodontal Therapy on Their Levels - A Preliminary Report

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