Salivary dehydroepiandrosterone (DHEA) levels in patients with the complaint of burning mouth: a case-control study

Fernandes, Carolina Sommer Dias; Salum, Fernanda Gonçalves; Bandeira, Denise Ruschel; Pawlowski, Josiane; Luz, Clarice; Cherubini, Karen

doi:10.1016/j.tripleo.2009.06.022

Cited by 37 publications

(51 citation statements)

References 46 publications

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“…We can divide the possible causes of BMS into local factors [26,[30][31][32][33][34][35][36], systemic factors [26,37] and psychological factors such as: stress, anxiety and depression [2,12,30,31,37,38]. At times BMS can be directly related to a pathogenic factor that can act in either a local or systemic way.…”

Section: Pathogenesismentioning

confidence: 99%

Burning Mouth Syndrome. Update

Jc¹,

E²,

Ej³

et al. 2014

J. Dentists

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Burning Mouth Syndrome (BMS) is a chronic disorder that predominately affects middle-aged women in the postmenopausal period. The condition is distinguished by burning symptoms of the oral mucosa and the absence of any clinical signs. The etiology of BMS is complex and it includes a variety of factors. Local, systemic and psychological factors such as stress, anxiety and depression are listed among the possible causes of BMS. BMS may sometimes be classified as BMS Type I, II or III. Although this syndrome is not accompanied by evident organic alterations and it does not present health risks, it can significantly reduce the patient's quality of life. This study analyzes the available literature related to BMS, and makes special reference to its therapeutic management. The pages that follow will also discuss the diagnostic criteria that should be respected, etiological factors, and clinical aspects. We used the PubMed database and searched it by using the keywords "burning mouth syndrome", "BMS and review", and "burning mouth and review", in the title or abstract of the publication. BMS treatment usually steers towards the management of the symptoms; however, the specific local factors that could play a significant role in worsening the oral burning sensation should be eradicated. The most widely accepted treatment options that show variable results include tricyclic antidepressants, benzodiazepines and antipsychotic drugs; nevertheless there are other therapies that can also be carried out. Professionals that work in the field of dentistry should formulate standardized symptomatic and diagnostic criteria in order to more easily identify the most effective and reliable strategies in BMS treatment through multidisciplinary research.

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Section: Pathogenesismentioning

confidence: 99%

Burning Mouth Syndrome. Update

Jc¹,

E²,

Ej³

et al. 2014

J. Dentists

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“…Also excluded from this study were patients who presented changes in the blood count, in the serum levels of glucose, iron, folic acid and vitamin B 12 or ANF [anti-nuclear factor] reacting with titles equal or above 1:160.…”

Section: Methodsmentioning

confidence: 99%

“…That steroid seems to modulate the immune response, and the decrease of its serum concentrations is associated with the deterioration of several physiological functions [10]. Low concentrations of this steroid were found in patients with rheumatoid arthritis, systemic lupus erythematosus [11], panic syndrome and burning mouth syndrome [12]. In normal conditions DHEA is released synchronically with cortisol and it antagonizes several deleterious effects of that hormone [9].…”

Section: Introductionmentioning

confidence: 99%

Níveis salivares de cortisol e desidroepiandrosterona, estresse e ansiedade em pacientes com estomatite aftosa recorrente

Michel

Luz

Wudarcki

et al. 2016

Rev. Odonto Ciênc. (Online)

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Objective: In the present study we investigated salivary concentrations of the hormones cortisol and dehydroepiandrosterone (DHEA), stress and anxiety levels in patients with recurrent aphthous stomatitis (RAS). Methods: The sample consisted of 60 individuals of both sexes, aged between 18 and 50 years: 30 patients with RAS and 30 controls. Stress and anxiety were assessed using the Lipp's Adult Stress Symptom Inventory and the Beck's Anxiety Inventory, respectively. The saliva samples were collected in the morning and in the afternoon on the same day. In the RAS group, the samples were collected in the presence of active lesions and after remission. The salivary levels of cortisol and DHEA were determined by radioimmunoassay. Results: RAS patients exhibited significantly higher anxiety scores (P=0.001) and prevalence of stress (P=0.004). There was no significant difference in DHEA and cortisol levels between RAS and control groups. Cortisol levels (P=0.008 and P=0.001) and the cortisol/DHEA ratio (P=0.054 and P=0.007) were significantly increased in the RAS patients with active lesions comparing with the remission phase (P=0.007). Conclusion: The present study demonstrates an association of stress and anxiety with RAS. However cortisol and DHEA did not differ between patients with RAS and controls.

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Section: Aetiologymentioning

confidence: 99%

“…Many studies have investigated the relationship between burning symptoms and oral lesions, candidiasis, geographic tongue, hyposalivation or systemic diseases such as diabetes and nutritional deficiencies. 6,[17][18][19] However, these studies will not be discussed as the evidence does not characterise the true syndrome. Amongst the possible causes of BMS, hormonal, 20 neuropathic 21,22 and psychological factors stand out, as well as stress, anxiety and depression stand out.…”

Section: Aetiologymentioning

confidence: 99%

Aetiology and therapeutics of burning mouth syndrome: an update

et al. 2012

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Aetiology and therapeutics of burning mouth syndrome: an updateObjective: To provide a review on the aetiology and therapeutic options for the management of patients with burning mouth syndrome (BMS). Background: BMS is a chronic disorder that frequently affects women and is characterised by burning symptoms of the oral mucosa without clinical signs. This syndrome has a complex and multifactorial characteristics, but its aetiology remains unknown and this makes it difficult with regard to the treatment and management of such patients. Despite not being accompanied by evident organic changes and not presenting risks to health, BMS can significantly reduce the quality of life for patients. Methods and materials: The article reviews the literature regarding aetiologic factors, clinical implications and treatment of BMS. Conclusion: The involvement of neurological, emotional and hormonal alterations is proposed in BMS aetiology. However the mechanisms of its development are complex and not completely understood. Tricyclic antidepressants, benzodiazepines and antipsychotic drugs are the most accepted options in treatment and show variable results. The correct diagnosis of BMS and the exclusion of possible local or systemic factors that can be associated with the symptoms are fundamental. It is also important to evaluate the quality of life for these patients to recognise the potential impact of this condition on their lives.

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Salivary dehydroepiandrosterone (DHEA) levels in patients with the complaint of burning mouth: a case-control study

Cited by 37 publications

References 46 publications

Burning Mouth Syndrome. Update

Burning Mouth Syndrome. Update

Níveis salivares de cortisol e desidroepiandrosterona, estresse e ansiedade em pacientes com estomatite aftosa recorrente

Aetiology and therapeutics of burning mouth syndrome: an update

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