2013
DOI: 10.1111/jop.12084
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Abstract: Our results prove that impairment of the salivary glands in the course of systemic sclerosis may be attributed to free radicals, and it is correlated with disease duration.

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Cited by 41 publications
(61 citation statements)
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References 28 publications
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“…When the salivary flow is stimulated only the parotid gland contribution increases by 10–15%, the remaining salivary glands do not significantly increase their secretion . Therefore, considering the changes observed in the UWS one should keep in mind that they reflect mainly changes taking place in the submandibular gland, similarly in the SWS‐ in the parotid gland .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…When the salivary flow is stimulated only the parotid gland contribution increases by 10–15%, the remaining salivary glands do not significantly increase their secretion . Therefore, considering the changes observed in the UWS one should keep in mind that they reflect mainly changes taking place in the submandibular gland, similarly in the SWS‐ in the parotid gland .…”
Section: Discussionmentioning
confidence: 99%
“…Directly after collection, the saliva was centrifuged at 3000 g , 20 min at 4°C. Debris was discarded, the remaining supernatant was divided into 500 μl, frozen in liquid nitrogen and stored until analyzed .…”
Section: Methodsmentioning
confidence: 99%
“…Increased production of reactive oxygen species can be responsible for the direct activation of fibroblasts and the stimulation of TGF‐β secretion. Moreover, it can also worsen the development of fibrosis by altering the balance between proteases and anti‐proteases (Zalewska et al , ). Mason et al have observed an increased mast cell population in the salivary glands from SSc patients.…”
Section: Orofacial Manifestationsmentioning
confidence: 99%
“…Their dysfunction results in a change of the composition and amount of saliva provided to the oral cavity. If the pathology occurs for a longer period of time, these changes may impair oral health [32]. In the present study we established the role of oxidative stress in the pathogenesis and development of salivary glands pathology in MSG-induced obese rats as evidenced by significant increasing of TBA-reactive substances and OMP content and significant decresing of catalase activity compared with the control group.…”
Section: Discussionmentioning
confidence: 55%