Salicylate Accumulation Kinetics in Man

Levy, Gerhard; Tsuchiya, Tamehiro

doi:10.1056/nejm197208312870903

Cited by 162 publications

(55 citation statements)

References 8 publications

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“…These levels were found after 7 days for the enteric coated preparations and 10 days for regular aspirin. This agrees with an earlier study that showed similar findings after the repeated administration of large daily doses (6).…”

supporting

confidence: 94%

Regular and enteric coated aspirin: A reevaluation

Orozco-Alcala

Baum

1979

Arthritis & Rheumatism

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supporting

confidence: 94%

Regular and enteric coated aspirin: A reevaluation

Orozco-Alcala

Baum

1979

Arthritis & Rheumatism

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“…) In vitro studies using human platelet-rich plasma provided evidence that salicylate might diminish the effect of acetylsalicylic acid on cyclooxygenase and platelet function (Ali & McDonald, 1979;Brantmark etal., 1981;Dahl et al, 1983). Because salicylate is formed rapidly in vivo after administration of acetylsalicylic acid and then accumulates during prolonged treatment (Levy & Tsuchiya, 1972), this interference has been proposed to be of importance during antithrombotic prophylaxis with acetylsalicylic acid (Castellamau et al, 1981;Dejana et al, 1983). However, in vivo thrombus formation in the rat was found to be diminished after administration of acetylsalicylic acid (10 mg kg-) irrespective of pretreatment with sodium salicylate in different doses thus suggesting no effect of salicylate on the antithrombotic action of the acetylated compound (Philp & Paul, 1981).…”

Section: Introductionmentioning

confidence: 99%

Effects of salicylic and acetylsalicylic acid alone and in combination on platelet aggregation and prostanoid synthesis in man.

Rosenkranz¹,

Fischer²,

Meese³

et al. 1986

Brit J Clinical Pharma

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The present study was designed to investigate the effects of salicylate on the antiplatelet action of acetylsalicylic acid as well as on in vivo prostanoid formation and platelet function in healthy volunteers. In the first study six female volunteers received 350 mg acetylsalicylic acid intravenously, with and without previous oral administration of sodium salicylate (1200 mg daily for 3 days). Urinary prostanoid excretion as well as platelet aggregation and thromboxane formation were measured before and during salicylate and after acetylsalicylic acid. In the second study seven female volunteers received sodium salicylate (52.6 mg kg‐1) or acetylsalicylic acid (60.7 mg kg‐1) for 8 days in a randomized cross‐over protocol. Urinary prostanoid excretion, platelet aggregation and thromboxane formation as well as salicylate plasma concentrations were determined before, during and after administration of each drug. Sodium salicylate did not impair the complete suppression of arachidonic acid‐induced platelet thromboxane formation and aggregation obtained by the single intravenous dose of acetylsalicylic acid in the first study. Sodium salicylate in the second study did not affect urinary excretion of prostaglandin E2, its major urinary metabolite (7 alpha‐hydroxy‐5,11‐ diketo‐tetranor‐prostane‐1,16‐dioic acid), and 2,3‐dinor‐6‐keto‐ prostaglandin F1 alpha, the main urinary metabolite of epoprostenol (prostacyclin, PGI2). In contrast, acetylsalicylic acid significantly decreased excretion rates of these prostanoids by 64, 59 and 61%, respectively. In both studies platelet aggregation and thromboxane formation induced by collagen, thrombin or arachidonic acid were not significantly affected by salicylate administration, whereas acetylsalicylic acid inhibited platelet aggregation induced by all three agents as well as thrombin‐ and arachidonic acid induced thromboxane formation.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…After at least two successive sets of normal liver tests, buffered aspirin was begun at 50 mg/kg body weight/day in (13), and serum levels may continue to rise for several days after a dose increase when the serum level is high. When a serum level of 25-30 mg/100 ml was reached, the dosage was adjusted to maintain this level for 2 weeks unless bothersome side effects or evidence of liver injury occurred.…”

mentioning

confidence: 99%

Effect of aspirin on liver tests in patients with ra or sle and in normal volunteers

Seaman

Plötz

1976

Arthritis & Rheumatism

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Aspirin was given to 20 patients with RA, 16 patients with SLE, and 3 normal volunteers. Four of the RA patients, 7 of the SLE patients, and 1 normal volunteer developed abnormal liver tests during the study. The abnormalities (elevated transaminases) were most frequent and of rapid onset in patients with clinically active SLE. Increases in BUN and creatinine related to aspirin were observed in several subjects. In a retrospective survey of 80 patients with SLE, aspirin appeared responsible for two-thirds of episodes of liver test abnormalities in 19 patients.

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Salicylate Accumulation Kinetics in Man

Cited by 162 publications

References 8 publications

Regular and enteric coated aspirin: A reevaluation

Regular and enteric coated aspirin: A reevaluation

Effects of salicylic and acetylsalicylic acid alone and in combination on platelet aggregation and prostanoid synthesis in man.

Effect of aspirin on liver tests in patients with ra or sle and in normal volunteers

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