Salicylanilide Therapy in Tinea Capitis

Felsher, I. Myron

doi:10.1001/archderm.1948.01520200059008

Cited by 11 publications

(2 citation statements)

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“…Salicylanilides found their use in medicine already in the 1940s [ 15 , 16 ]. Later, halogenated salicylanilides were used in both human and veterinary medicine as effective anthelmintic drugs such as niclosamide, rafoxanide or closantel [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Salicylanilides and Their Anticancer Properties

Kauerova

Pérez‐Pérez

Kollár

2023

IJMS

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Salicylanilides are pharmacologically active compounds with a wide spectrum of biological effects. Halogenated salicylanilides, which have been used for decades in human and veterinary medicine as anthelmintics, have recently emerged as candidates for drug repurposing in oncology. The most prominent example of salicylanilide anthelmintic, that is intensively studied for its potential anticancer properties, is niclosamide. Nevertheless, recent studies have discovered extensive anticancer potential in a number of other salicylanilides. This potential of their anticancer action is mediated most likely by diverse mechanisms of action such as uncoupling of oxidative phosphorylation, inhibition of protein tyrosine kinase epidermal growth factor receptor, modulation of different signaling pathways as Wnt/β-catenin, mTORC1, STAT3, NF-κB and Notch signaling pathways or induction of B-Raf V600E inhibition. Here we provide a comprehensive overview of the current knowledge about the proposed mechanisms of action of anticancer activity of salicylanilides based on preclinical in vitro and in vivo studies, or structural requirements for such an activity.

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Section: Introductionmentioning

confidence: 99%

Salicylanilides and Their Anticancer Properties

Kauerova

Pérez‐Pérez

Kollár

2023

IJMS

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“…In agriculture, it plays an important role in prevention and treatment of fruit and vegetable diseases . Besides, salicylanilide can be mixed with undecylenic acid into a variety of pharmaceutical preparations to treat the skin tinea disease caused by mold in medicine. − Currently, salicylanilide can be synthesized by the reaction between phenyl salicylate and aniline at a certain temperature, and then separated from the reaction solution by crystallization . The quality of the final product, including crystal size distribution, crystal habit, purity, and so on, depends largely on the crystallization process.…”

Section: Introductionmentioning

confidence: 99%

Solubility Measurement and Data Correlation of Salicylanilide in 12 Pure Solvents at Temperatures Ranging from 283.15 to 323.15 K

et al. 2021

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The solubility of salicylanilide in 12 pure solvents including ethanol, n-propanol, isopropanol, n-butanol, n-pentanol, ethyl formate, methyl acetate, ethyl acetate, propyl acetate, isopropyl acetate, butyl acetate, and acetonitrile was measured using the gravimetric method at temperatures ranging from 283.15 to 323.15 K. The experimental results show that the solubility of salicylanilide is lower in alcohol than in ester solvents. In addition, the mole fraction solubility of salicylanilide in these selected solvents increases with the increase of temperature and presents the following order at a fixed temperature: ethanol > isopropanol > n-propanol > n-butanol > n-pentanol, methyl acetate > ethyl acetate > propyl acetate > isopropyl acetate > butyl acetate > ethyl formate > acetonitrile. Three models, including the modified Apelblat equation, the van’t Hoff equation, and the λh equation, were applied to correlate the measured solubility data. The results indicate that the three models can predict the experimental values satisfactorily and the modified Apelblat equation is more appropriate to correlate the solubility data in 12 solvents.

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Die Epilationsbestrahlung

Wagner¹

1959

Strahlentherapie Von Hautkrankheiten

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Salicylanilide Therapy in Tinea Capitis

Cited by 11 publications

References 1 publication

Salicylanilides and Their Anticancer Properties

Salicylanilides and Their Anticancer Properties

Solubility Measurement and Data Correlation of Salicylanilide in 12 Pure Solvents at Temperatures Ranging from 283.15 to 323.15 K

Die Epilationsbestrahlung

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