1997
DOI: 10.1080/109158197227350 View full text |Buy / Rent full text
|
|

Abstract: Undesired pharmacologic activities of novel drugs or biologies may limit development of a therapeutic prior to the characterization of any toxicologic effects. In rodent species, general pharmacology assays have traditionally been used to screen new agents for pharmacologic effects on the central and peripheral nervous systems, the autonomic nervous system and smooth muscles, the respiratory and cardiovascular systems, the digestive system, and the physiologic mechanisms of water and electrolyte balance. In la… Show more

Help me understand this report

Search citation statements

Order By: Relevance
Select...
1
1
1
0
4
0

Year Published

2006
2006
2018
2018

Publication Types

Select...
2
1

Relationship

0
3

Authors

Journals

0
4
0
Order By: Relevance
“…Measuring GIT transit time is a standard way of examining GIT motility. 46,47 It has been reported that opioid agonists not only reduce GIT motility and secretion but also enhance reabsorption of water in the gastrointestinal tract by activating peripheral MOR. 48,49 The carmine red GIT transit study was conducted to determine whether dMNAP and dMNMP had any effect on GIT motility.…”
Section: Resultsmentioning
See 1 more Smart Citation
Create an account to read the remaining citation statements from this report. You will also get access to:
  • Search over 1.2b+ citation statments to see what is being said about any topic in the research literature
  • Advanced Search to find publications that support or contrast your research
  • Citation reports and visualizations to easily see what publications are saying about each other
  • Browser extension to see Smart Citations wherever you read research
  • Dashboards to evaluate and keep track of groups of publications
  • Alerts to stay on top of citations as they happen
  • Automated reference checks to make sure you are citing reliable research in your manuscripts
  • 7 day free preview of our premium features.

Trusted by researchers and organizations around the world

Over 130,000 students researchers, and industry experts at use scite

See what students are saying

rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…Measuring GIT transit time is a standard way of examining GIT motility. 46,47 It has been reported that opioid agonists not only reduce GIT motility and secretion but also enhance reabsorption of water in the gastrointestinal tract by activating peripheral MOR. 48,49 The carmine red GIT transit study was conducted to determine whether dMNAP and dMNMP had any effect on GIT motility.…”
Section: Resultsmentioning
“…Measuring GIT transit time is a standard way of examining GIT motility. , It has been reported that opioid agonists not only reduce GIT motility and secretion but also enhance reabsorption of water in the gastrointestinal tract by activating peripheral MOR. , The carmine red GIT transit study was conducted to determine whether dMNAP and dMNMP had any effect on GIT motility. In this assay, the test compounds at a single dose (10 mg/kg) were first administered s.c. at time zero. Morphine (10 mg/kg) and saline were used as positive and negative controls, respectively.…”
Section: Results and Discussionmentioning
“…19,20 Hence, it was adopted in the current study to test the effect of NAP on GI motility following the published protocol with minor modification. 2123 Briefly, seven groups of five morphine-pelleted (10 mg/kg) mice each received a subcutaneous (s.c.) injection of NAP at different concentrations or saline at time zero.…”
mentioning
“…The organ systems and functions most frequently responsible in these events are the central nervous (seizure), cardiovascular (hypotension, hypertension, and arrhythmia), respiratory (asthma/bronchoconstriction), and renal (glomerular filtration) systems, and the result is almost always a critical care emergency (Kinter et al 1997). The origins of safety pharmacology are grounded upon observations that organ functions (like organ structures) can be toxicological targets in humans exposed to novel therapeutic agents and that drug effects on organ functions (unlike organ structures) are not readily detected by standard toxicological testing (see Mortin et al 1997;Williams 1990;Zbinden 1984).…”
Section: Ib1 Origins Of Safety Pharmacologymentioning