Safety guidelines for copper in water

Fitzgerald, D J

doi:10.1093/ajcn/67.5.1098s

Cited by 98 publications

(40 citation statements)

References 6 publications

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“…The Canadian DWG of 1 mg/L for copper is an aesthetic objective based on taste, staining of laundry, and plumbing fixtures. This value is consistent with aesthetics-based guidelines set by other countries and is considered to be protective of health (Fitzgerald 1998;Health Canada 1992a). The World Health Organization (WHO) health-based guideline for copper in drinking water is 2 mg/L (World Health Organization 2004), whereas the US Environmental Protection Agency's (EPA) health-based maximum contaminant level goal is 1.3 mg/L (US Environmental Protection Agency 2012).…”

Section: Reference Values For Copper and Leadsupporting

confidence: 84%

Investigating elevated copper and lead levels in school drinking water

Barn

Nicol

Struck

et al. 2013

Environ. Health Rev.

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Copper and lead continue to be detected at levels above drinking water guidelines in Canadian schools. Although water is typically not an important source of these metals, intermittent use and corrosive water can cause copper and lead to leach from plumbing. Exposure to elevated copper levels is linked to acute gastrointestinal effects in the short term and possible liver effects in the long term, whereas even low level lead exposures are associated with neurodevelopmental effects. Because school water is not regularly monitored for corrosion metals, elevated concentrations are often brought to the attention of public health officials through unexpected circumstances. Here, the death of salmon eggs in a classroom aquarium triggered an investigation that found elevated levels of copper and lead in the school's drinking water. The investigation was then expanded to the school district. Copper and lead levels varied considerably across schools as well as in outlets located in the same school. The effectiveness of flushing, which was implemented as a mitigation strategy, was also found to differ by school building and outlet. Actions described in this case report may be informative for health authorities across Canada.

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Section: Reference Values For Copper and Leadsupporting

confidence: 84%

Investigating elevated copper and lead levels in school drinking water

Barn

Nicol

Struck

et al. 2013

Environ. Health Rev.

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“…The limit of copper concentration above which aqueous solution may pose a threat to human health has been set to 31 μM by the World Health Organization [34]. Since the developed biosensor was able to measure the presence of copper in the 0.1-10 μM range, it could perform copper quantification in aqueous solutions both at toxic and nontoxic concentrations by opportune dilution of the sample.…”

Section: +mentioning

confidence: 99%

Development of a Biosensor for Copper Detection in Aqueous Solutions Using an Anemonia sulcata Recombinant GFP

Masullo

Puccio²,

Pierro³

et al. 2013

Appl Biochem Biotechnol

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Fluorescent proteins from marine organisms represent potential candidates for biosensor development. In this paper, we described the isolation of a native green fluorescent protein from Anemonia sulcata and the cloning and purification of its equivalent as a recombinant protein in Escherichia coli. Furthermore, the spectroscopic behaviours of the native and recombinant GFPs were investigated as a function of Cu concentration. Our results suggest the high selectivity of both proteins at copper than the other metals and, for the recombinant protein, a great sensitivity at a very low concentration (0.1-1 μM). Moreover, starting from these data, using the combination of molecular biology Appl Biochem Biotechnol (2014) techniques and optical setup, we developed a device for the detection of Cu 2+ in water solutions. The quenching effect detected with the device showed that the relative attenuation of the signal (0.46±0.02 AU) was slightly larger than the data measured by fluorescence spectra (0.65±0.03 AU). The good sensitivity in the span of two orders of the magnitude of Cu 2+ concentration, the fact that the instrument is made up of low-cost and sturdy parts and the selective quenching of rAsGFP to copper ions make this setup suited as a low cost, on-thefield, copper ion-specific biosensor.

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“…9 In the U.S., the health-based guideline for a maximum water copper concentration of 1.3 mg/liter is enforced by the Environmental Protection Agency (EPA). 10 Symptoms of acute copper toxicity include abdominal pain, nausea, vomiting, and diarrhea, which help prevent additional ingestion and absorption of copper. More serious signs of acute copper toxicity include severe liver damage, kidney failure, coma, and death.…”

Section: Discussionmentioning

confidence: 99%

“…9 Higher concentrations of ceruloplasmin have known to have a role in numerous cancers. 10 The thickness of the endometrium in DUB is measured by ultrasound. If necessary, a layer of endometrium is surgically removed by curettage.…”

Section: Introductionmentioning

confidence: 99%