Safety Evaluation of Nanotechnology Products

Domb, Abraham J.; Sharifzadeh, Ghorbanali; Nahum, Victoria; Hosseinkhani, Hossein

doi:10.3390/pharmaceutics13101615

Cited by 28 publications

(17 citation statements)

References 333 publications

(320 reference statements)

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“…For instance, several liposomal and small interfering RNA (siRNA) delivery systems interact with serum lipoproteins [ 92 , 93 ]. Conversely, undesirable aggregation can occur in particles with high positive surface charges [ 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 ]. A suitable method for decreasing non-specific interactions involves mostly the use of polyethylene glycol (PEG) that protects the surface of delivery carriers [ 107 ].…”

Section: Gene Therapy Systemsmentioning

confidence: 99%

Gene Therapy for Regenerative Medicine

et al. 2023

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The development of biological methods over the past decade has stimulated great interest in the possibility to regenerate human tissues. Advances in stem cell research, gene therapy, and tissue engineering have accelerated the technology in tissue and organ regeneration. However, despite significant progress in this area, there are still several technical issues that must be addressed, especially in the clinical use of gene therapy. The aims of gene therapy include utilising cells to produce a suitable protein, silencing over-producing proteins, and genetically modifying and repairing cell functions that may affect disease conditions. While most current gene therapy clinical trials are based on cell- and viral-mediated approaches, non-viral gene transfection agents are emerging as potentially safe and effective in the treatment of a wide variety of genetic and acquired diseases. Gene therapy based on viral vectors may induce pathogenicity and immunogenicity. Therefore, significant efforts are being invested in non-viral vectors to enhance their efficiency to a level comparable to the viral vector. Non-viral technologies consist of plasmid-based expression systems containing a gene encoding, a therapeutic protein, and synthetic gene delivery systems. One possible approach to enhance non-viral vector ability or to be an alternative to viral vectors would be to use tissue engineering technology for regenerative medicine therapy. This review provides a critical view of gene therapy with a major focus on the development of regenerative medicine technologies to control the in vivo location and function of administered genes.

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Section: Gene Therapy Systemsmentioning

confidence: 99%

Gene Therapy for Regenerative Medicine

et al. 2023

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“…The use of chemicals and solvents used in chemical experiments are toxic to the biological system and the atmosphere, Advances in the molecular study of matter at the nanoscale have enabled the understanding, analysis, quantification and development of new materials, So he took refugea researchers to find asafer methods a For the production of nanomaterials, such as the use of fungi, bacteria or plants, and because chemical and physical methods are expensive and have many limitations. So damage Scientists have developed an approacha biologyacleanaeconomicallyaand a frienda environment as alternative methods for the production of nanomaterials (Domb et al, 2021) Nanomaterials (NMs)…”

Section: Review Of References Nanotechnologymentioning

confidence: 99%

Biosynthesis of selenium nanoparticles by Candida albicans and them antimicrobial effects

2023

JPTCP

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“…The main parameters used to evaluate nanotoxicity include the study of the targets of the nanomaterials (biodistribution and cellular uptake), the assessment of the induction of cytotoxicity (cell damage, cell death), the pro-inflammatory response, oxidative stress, and genotoxic effects as these events have been reported to be the mechanisms of action of nanomaterial toxicity [10][11][12].…”

Section: Experimental Nanotoxicology/empirical Approachesmentioning

confidence: 99%

“…Nanomaterials can induce toxicity both in vitro and in vivo through various mechanisms such as oxidative stress, cell death mechanisms (apoptosis, autophagy, and necrosis), genotoxicity, and immunological responses [10][11][12]19,52]. Different assays allow evaluating these biological endpoints to report on the nanotoxicity; they can be subdivided into cytotoxicity assessment (including cell viability, proliferation, and cell death assays), proinflammatory response, oxidative stress, and genotoxicity [11].…”

Section: Main Biological Endpoints Consideredmentioning

confidence: 99%

Experimental and Computational Nanotoxicology—Complementary Approaches for Nanomaterial Hazard Assessment

Forest

2022

Nanomaterials

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The growing development and applications of nanomaterials lead to an increasing release of these materials in the environment. The adverse effects they may elicit on ecosystems or human health are not always fully characterized. Such potential toxicity must be carefully assessed with the underlying mechanisms elucidated. To that purpose, different approaches can be used. First, experimental toxicology consisting of conducting in vitro or in vivo experiments (including clinical studies) can be used to evaluate the nanomaterial hazard. It can rely on variable models (more or less complex), allowing the investigation of different biological endpoints. The respective advantages and limitations of in vitro and in vivo models are discussed as well as some issues associated with experimental nanotoxicology. Perspectives of future developments in the field are also proposed. Second, computational nanotoxicology, i.e., in silico approaches, can be used to predict nanomaterial toxicity. In this context, we describe the general principles, advantages, and limitations especially of quantitative structure–activity relationship (QSAR) models and grouping/read-across approaches. The aim of this review is to provide an overview of these different approaches based on examples and highlight their complementarity.

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Safety Evaluation of Nanotechnology Products

Cited by 28 publications

References 333 publications

Gene Therapy for Regenerative Medicine

Gene Therapy for Regenerative Medicine

Biosynthesis of selenium nanoparticles by Candida albicans and them antimicrobial effects

Experimental and Computational Nanotoxicology—Complementary Approaches for Nanomaterial Hazard Assessment

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