Safety Data of Injectable Nonanimal Stabilized Hyaluronic Acid Gel for Soft Tissue Augmentation

Abstract

According to the reported worldwide adverse events data, hypersensitivity to nonanimal hyaluronic acid gel is the major adverse event and is most likely secondary to impurities of bacterial fermentation. According to data from 2000, the incidence of hypersensitivity appears to be declining after the introduction of a more purified hyaluronic acid raw material.

Injectable Hyaluronic Acid Implant for Malar and Mental Enhancement

“…[1][2][3][4][5] Most uses of these fillers have been in the nasolabial lines, for lip augmentation and for treatment of atrophic scars, and some of the thinner, less viscous hyaluronic acid fillers have been utilized for the forehead, periorbital area, and glabelar lines. 1,2,4,5 Refinements to manufacturing and formulation of Restylane products in 2000 have led to a reduced incidence of delayed reactions. 1,4 A recent development is a more viscous, longer-lasting version of Restylane termed Restylane SubQ (Q-Med, Uppsala, Sweden).…”

Radiofrequency waves with filling and peeling substances: An innovative minimally invasive technique for facial rejuvenation

“…Physicians who administer dermal fillers and neuromodulators must carefully select the patients and discuss with them the benefits and limitations. Moreover, the physicians should have a thorough knowledge of the characteristics of the injectables and of the anatomy of the area to be treated 9. Nevertheless, many aspects of facial rejuvenation still require surgical intervention 10.…”

A hypothetical correlation between hyaluronic acid gel and development of cutaneous metaplastic synovial cyst

“…They are generally short-term and symptoms typically include swelling, pain, tenderness, and bruising; these symptoms can be observed in most patients treated with injectable hyaluronic acid derivatives [3]. Besides, the overall incidence of long-term adverse reactions secondary to injection of hyaluronic acid skin fillers is believed to be low, and the vast majority of them represent a foreign body-related chronic inflammatory reaction.…”