Safety concerns when using novel medications to treat alopecia

Almohanna, Hind M.; Perper, Marina; Tosti, Antonella

doi:10.1080/14740338.2018.1533549

Cited by 40 publications

(32 citation statements)

References 130 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among the uses of mesotherapy is the treatment of androgenetic alopecia . However, scarring or nonscarring alopecia can occur as a result of the treatment itself, mostly due to mesotherapy‐induced fat necrosis and abscess formation .…”

Section: Resultsmentioning

confidence: 99%

“…Less grave complications of mesotherapy include procedure‐associated pain, bruising, and edema due to the inflammation provoked by the injected substances. These tend to be rather localized and transient, and their management includes the application of local anesthetics as well as larger time intervals between visits . Mild symptoms of self‐limiting headache and pruritus have also been described in scalp‐mesotherapy treatment .…”

Section: Resultsmentioning

confidence: 99%

“…32 Among the uses of mesotherapy is the treatment of androgenetic alopecia. 4 However, scarring or nonscarring alopecia can occur as a result of the treatment itself, mostly due to mesotherapy-induced fat necrosis and abscess formation. 33 In such a case presented by Kadry et al, the conservative treatment seemed to show no effect; so the surgical removal of the inflamed tissues was selected as the treatment of choice.…”

Section: Granulomatous Foreign Body Reactions Have Been Reported Tomentioning

confidence: 99%

“…The external application of these active substances could not lead to the same results, either due to the impairment of their penetration through the lipid barrier and the stratum corneum, or due to their chemical decomposition on the epidermis surface . Mesotherapy has gained massive popularity over the last years, due to the fact that it offers an inexpensive direct drug delivery in the area of interest and it requires minimal training for the physicians . The development of various mesotherapeutic protocols for numerous indications makes the cumulative safety evaluation difficult and no larger cohort studies for risk assessment on mesotherapy have been conducted up to this point .…”

Section: Introductionmentioning

confidence: 99%

“…2,3 Mesotherapy has gained massive popularity over the last years, due to the fact that it offers an inexpensive direct drug delivery in the area of interest and it requires minimal training for the physicians. 4 The development of various mesotherapeutic protocols for numerous indications makes the cumulative safety evaluation difficult and no larger cohort studies for risk assessment on mesotherapy have been conducted up to this point. 5 This report aims to present all the mesotherapy-associated complications reported in the literature so far and to provide an insight into as far as their management is concerned.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Mesotherapy: Safety profile and management of complications

Plachouri

Georgiou

2019

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Background Mesotherapy is a procedure that involves the injection of active substances into the dermis and subcutaneous tissue in order to treat several local medical and cosmetic conditions. Despite being considered as a relatively safe method, a series of adverse reactions can occur due to its wide application and lack of standardization processes. Objectives The aim of this paper is to summarize all the mesotherapy‐related complications published so far, and to provide an insight into their management. Patient/Methods Articles derived from the databases, PubMed, EMBASE, and SCOPUS, and published between 1992 and 2018, were analyzed for this review. The study was conducted according to the PRISMA guidelines. Results In this literature, there is a number of case series and isolated case reports describing various side effects of different severities. The therapeutic management of these complications is—in most cases—individualized. Conclusions Larger systematic studies are needed in order to adequately evaluate the safety profile of mesotherapy, and in order to determine standardized therapy parameters, so as to minimize the risk of potential adverse reactions.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%