Safety assessment of Piper cernuum Vell. (Piperaceae) leaves extract: Acute, sub-acute toxicity and genotoxicity studies

Wolff, Fellippe Ramos; Broering, Milena Fronza; Jurcevic, Jocilene Demétrio; Zermiani, Taylin; Bramorski, Adriana; Vitorino, Josiane de Carvalho; Malheiros, Ângela; Santin, José Roberto

doi:10.1016/j.jep.2018.10.035

Cited by 15 publications

(13 citation statements)

References 19 publications

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“…The leaves of P. cernuum have been commonly used by rural and urban communities in São Paulo, Brazil, to treat topical pain conditions, such as bellyache and muscle pain, in addition to hepatic and renal complications [220].…”

Section: Traditional Uses Of Piper Speciesmentioning

confidence: 99%

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

et al. 2019

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Piper species are aromatic plants used as spices in the kitchen, but their secondary metabolites have also shown biological effects on human health. These plants are rich in essential oils, which can be found in their fruits, seeds, leaves, branches, roots and stems. Some Piper species have simple chemical profiles, while others, such as Piper nigrum, Piper betle, and Piper auritum, contain very diverse suites of secondary metabolites. In traditional medicine, Piper species have been used worldwide to treat several diseases such as urological problems, skin, liver and stomach ailments, for wound healing, and as antipyretic and anti-inflammatory agents. In addition, Piper species could be used as natural antioxidants and antimicrobial agents in food preservation. The phytochemicals and essential oils of Piper species have shown strong antioxidant activity, in comparison with synthetic antioxidants, and demonstrated antibacterial and antifungal activities against human pathogens. Moreover, Piper species possess therapeutic and preventive potential against several chronic disorders. Among the functional properties of Piper plants/extracts/active components the antiproliferative, anti-inflammatory, and neuropharmacological activities of the extracts and extract-derived bioactive constituents are thought to be key effects for the protection against chronic conditions, based on preclinical in vitro and in vivo studies, besides clinical studies. Habitats and cultivation of Piper species are also covered in this review. In this current work, available literature of chemical constituents of the essential oils Piper plants, their use in traditional medicine, their applications as a food preservative, their antiparasitic activities and other important biological activities are reviewed.

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Section: Traditional Uses Of Piper Speciesmentioning

confidence: 99%

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

et al. 2019

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“…The toxicological stress response of TCA on HSPs is being reported for the first time to the best of our knowledge. An induction of haematological alterations in animals by extracts or substances usually infers a high risk of toxicity [ 32 ]. The insignificant alteration of haematological parameters corroborates the biochemical results, indicating that TCA elicits “no observed adverse effect level” (NOAEL).…”

Section: Discussionmentioning

confidence: 99%

Toxicopathological, proinflammatory and stress response evaluation of Terminalia catappa extract in male Wistar rats

et al. 2021

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“…All mice were kept in a climate-controlled feeding room at 22 ± 2 °C under light/dark (12:12) cycle and were provided with food and water ad libitum . The relative humidity of the feeding room was controlled at 50 ± 10%.…”

Section: Methodsmentioning

confidence: 99%

“…All mice were kept in a climatecontrolled feeding room at 22 ± 2 °C under light/dark (12:12) cycle and were provided with food and water ad libitum. 31 The relative humidity of the feeding room was controlled at 50 ± 10%. All mice were raised for three days to adapt to the feeding room environment before commencement of the acute and subacute toxicity experiments.…”

Section: ■ Introductionmentioning

confidence: 99%

Acute and Subacute Toxicity Study of Graphene-Based Tumor Cell Nucleus-Targeting Fluorescent Nanoprobes

et al. 2020

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Graphene-based tumor cell nuclear targeting fluorescent nanoprobes (GTTNs) were synthesized in our laboratory as a kind of nanomaterial and showed good performance for both in vivo and in vitro imaging. GTTNs directly cross the cell membrane and specifically target the tumor cell nucleus via a cell membrane permeability targeting (CMPT) mechanism, which takes advantage of the increased permeability of the tumor cell membranes. GTTNs with a CMPT mechanism achieve high targeting efficiency in tumor tissues. With the tumor cell nucleus-targeting characterization, the GTTN distinguishes tumor cells at the single-cell level and recognizes the tumor tissue interface in a very early stage and shows great potential in clinical applications. Toxicity studies are extremely critical for clinical applications. Therefore, we studied the acute and subacute toxicity of GTTNs using an in vivo method and examined the following experimental indicators: mouse body weight, organ coefficients, serum biochemical parameters, and histological changes. The results showed that there were no significant differences in any indicators between the experimental and control mice. We also used an in vitro method to study the cytotoxicity of GTTNs in GES-1 (gastric epithelial cell) cells. Surprisingly, the results demonstrated over 80% cell viability when the incubation time reached up to 72 h under a 200 mg/L concentration of GTTNs, which indicated that GTTNs had low cytotoxicity. GTTNs barely showed any acute or subacute toxicity or cytotoxicity in vivo and in vitro, respectively, which supports their use for clinical applications.

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Safety assessment of Piper cernuum Vell. (Piperaceae) leaves extract: Acute, sub-acute toxicity and genotoxicity studies

Cited by 15 publications

References 19 publications

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

Toxicopathological, proinflammatory and stress response evaluation of Terminalia catappa extract in male Wistar rats

Acute and Subacute Toxicity Study of Graphene-Based Tumor Cell Nucleus-Targeting Fluorescent Nanoprobes

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