Safety Assessment of Glycerin as Used in Cosmetics

Becker, Lillian C.; Bergfeld, Wilma F.; Belsito, D.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, D.C.; Marks, James G.; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Gill, Lillian J.; Heldreth, Bart

doi:10.1177/1091581819883820

Cited by 67 publications

(36 citation statements)

References 30 publications

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“…In particular, both glycerol and propylene glycol are among the most widely used raw materials in food, cosmetic and pharmaceutical industries. Glycerol shows excellent solubility in water, and, due to its GRAS status, it is very safe to use [29]. Propylene glycol is a colorless, odorless and completely water-soluble solvent very similar to glycerol, also having the GRAS status and high safety [30].…”

Section: Development and Optimisation Of Nanovesicles Loaded With Ooeo And Steomentioning

confidence: 99%

Nanovesicles Loaded with Origanum onites and Satureja thymbra Essential Oils and Their Activity against Food-Borne Pathogens and Spoilage Microorganisms

et al. 2021

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Food poisoning is a common cause of illness and death in developing countries. Essential oils (EOs) could be effective and safe natural preservatives to prevent and control bacterial contamination of foods. However, their high sensitivity and strong flavor limit their application and biological effectiveness. The aim of this study was firstly the chemical analysis and the antimicrobial evaluation of the EOs of Origanum onites L. and Satureja thymbra L. obtained from Symi island (Greece), and, secondly, the formulation of propylene glycol-nanovesicles loaded with these EOs to improve their antimicrobial properties. The EOs were analyzed by GC-MS and their chemical contents are presented herein. Different nanovesicles were formulated with small average sizes, high homogeneity, and optimal ζ-potential. Microscopic observation confirmed their small and spherical shape. Antibacterial and antifungal activities of the formulated EOs were evaluated against food-borne pathogens and spoilage microorganisms compared to pure EOs. Propylene glycol-nanovesicles loaded with O. onites EO were found to be the most active formulation against all tested strains. Additionally, in vitro studies on the HaCaT cell line showed that nanovesicles encapsulated with EOs had no toxic effect. The present study revealed that both EOs can be used as alternative sanitizers and preservatives in the food industry, and that their formulation in nanovesicles can provide a suitable approach as food-grade delivery system.

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Section: Development and Optimisation Of Nanovesicles Loaded With Ooeo And Steomentioning

confidence: 99%

Nanovesicles Loaded with Origanum onites and Satureja thymbra Essential Oils and Their Activity against Food-Borne Pathogens and Spoilage Microorganisms

et al. 2021

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“…For the 50% glycerol with topical application, 50% glycerol is safe for in vivo human skin applications and been allowed as human skincare products. The safety assessment of The Cosmetic Ingredient Review Expert Panel (CIR) reported that glycerin can be used at concentrations up to 78.5% in leave-on products 53 . The results of 50% glycerol topical application will help future in vivo human skin trials.…”

Section: Investigating the Optical Clearing Effects Of 50% Glycerol Imentioning

confidence: 99%

Investigating the optical clearing effects of 50% glycerol in ex vivo human skin by harmonic generation microscopy

Lai

Liao

et al. 2021

Sci Rep

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Imaging depth and quality of optical microscopy can be enhanced by optical clearing. Here we investigate the optical clearing of the ex vivo human skin by 50% glycerol topical application, which is allowed for cosmetic usage. Harmonic generation microscopy, by combining second and third harmonic generation (THG) modalities, was utilized to examine the clearing effect. The THG image intensity is sensitive to the improved optical homogeneity after optical clearing, and the second harmonic generation (SHG) image intensity in the dermis could serve as a beacon to confirm the reduction of the scattering in the epidermis layer. As a result, our study supports the OC effect through 50% glycerol topical application. Our study further indicates the critical role of stratum corneum shrinkage for the observed SHG and THG signal recovery.

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“…Natrium Klorida adalah untuk meningkatkan viskositas SLES , juga penambahan glyceryl stearat mempercantik penampilan sabun menjadi putih dengan hasil busa lebih creamy (Elder, 1982). Cocomide DEA sebagai pembentuk busa seperti halnya SLES (Prayadnya et al, 2017) akan memberikan sensasi bahwa sabun cair ini memiliki daya bersih, sedangkan gliserin memberikan rasa lembut pada kulit (Becker et al, 2019).…”

Section: Introductionunclassified

Pengembangan Produk Kosmetika Berbahan Susu Kambing menjadi Sabun Cair

Chasanah

Rahmasari

2021

Pengabdianmu J Ilmiah Pengabdian Masyarakat

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Goat's milk is rich in nutrients, especially vitamin A and lactic acid which are very beneficial for skin health, so it is suitable for liquid bath soap ingredients. However, well-known manufacturing takes a long time to make. Implemented training to producers of fresh goat's milk is formulating liquid soap made from fresh goat's milk that a simple method and quickly. The result of this activity is an increase in the knowledge and skills of participants so that they can enrich the variety of products based on fresh goat milk. It is hoped that with the increasing variety of goat milk products that they offer, there will be an increase in the economy of participants.

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Safety Assessment of Glycerin as Used in Cosmetics

Cited by 67 publications

References 30 publications

Nanovesicles Loaded with Origanum onites and Satureja thymbra Essential Oils and Their Activity against Food-Borne Pathogens and Spoilage Microorganisms

Nanovesicles Loaded with Origanum onites and Satureja thymbra Essential Oils and Their Activity against Food-Borne Pathogens and Spoilage Microorganisms

Investigating the optical clearing effects of 50% glycerol in ex vivo human skin by harmonic generation microscopy

Pengembangan Produk Kosmetika Berbahan Susu Kambing menjadi Sabun Cair

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