Safety and performance benefits of arginine supplements for military personnel: a systematic review

Brooks, James R.; Oketch-Rabah, Hellen A.; Dog, Tieraona Low; Gorecki, D. K. J.; Barrett, Marilyn; Cantilena, Louis R.; Chung, Mei; Costello, Rebecca B.; Dwyer, Johanna; Hardy, Mary; Jordan, Scott A.; Maughan, Ronald J.; Marles, Robin J.; Osterberg, Robert E.; Rodda, Bruce E.; Wolfe, Robert R.; Zúñiga, Jorge M.; Valerio, Luis G.; Jones, Donnamaria; Deuster, Patricia A.; Giancaspro, Gabriel I.; Sarma, Nandakumara D.

doi:10.1093/nutrit/nuw040

Cited by 11 publications

(4 citation statements)

References 76 publications

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“…Thousands of people self-medicate with dietary supplements containing unknown quantities of pharmacologically active compounds. These poorly regulated substances can cause real harm to people ( Brooks et al., 2016 ). The monitoring of these products depends directly on the available analytical methods to detect the presence of adulterant substances in various types of samples ( Viana et al., 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Involvement of serotonergic pathways in gastric dysmotility induced by fat burning nutritional supplements in mice

Sousa

Sant'ana

Santos

et al. 2021

Current Research in Pharmacology and Drug Discovery

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Fat burners are a category of nutritional supplements that are claimed to increase the metabolism and promote greater energy expenditure, leading to weight loss. However, little is known about the side effects on gastrointestinal motility. In this study, we evaluated the effect of ingestion with a fat burner named Thermbuterol® (THERM) on the gastric motility and food behavior of mice. THERM compounds were identified using nuclear magnetic resonance (NMR). Mice received variable doses of THERM (10, 50, 100 or 300 mg/kg, p.o.) or NaCl 0.15 M (control). Gastric emptying (GE) was assessed using the phenol red technique. Another set of mice was pretreated with intraperitoneal administration of hexamethonium (HEXA, 10 mg/kg), prazosin (PRAZ, 0.25 mg/kg), propranolol (PROP, 2 mg/kg), parachlorophenylalanine (PCPA, 300 mg/kg) or ondansetron (ONDA, 50 μg/kg) 30 min before THERM treatment for evaluation of GE. We assessed the gastrointestinal responsiveness in vitro as well as THERM's effects on food behavior. Caffeine was the major compound of THERM, identified by NMR. THERM 100 and 300 mg/kg decreased GE compared to the respective controls. Pretreatment with PRAZ or PROP did not prevent gastric dysmotility induced by THERM 100 mg/kg. However, the pretreatment with HEXA, ONDA or PCPA prevented GE delay induced by THERM. In vitro , THERM relaxed contractions in strips of longitudinal gastric fundus and duodenum. THERM also increased food intake, which was prevented by PCPA and ONDA treatments. THERM decreased GE of a liquid and increased food intake in mice, a phenomenon mediated by the autonomic nicotinic receptors and serotoninergic receptor.

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Section: Discussionmentioning

confidence: 99%

Involvement of serotonergic pathways in gastric dysmotility induced by fat burning nutritional supplements in mice

Sousa

Sant'ana

Santos

et al. 2021

Current Research in Pharmacology and Drug Discovery

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“…ODS has sponsored a series of technical reports on the application of review methodology to the field of nutrition and dietary supplements [ 81 , 82 , 83 , 84 , 85 , 86 ]. Staff have also collaborated in performing systematic reviews with other groups [ 87 , 88 ].…”

Section: Case Study: Office Of Dietary Supplements (Ods) Nationalmentioning

confidence: 99%

Dietary Supplements: Regulatory Challenges and Research Resources

2018

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Many of the scientific and regulatory challenges that exist in research on the safety, quality and efficacy of dietary supplements are common to all countries as the marketplace for them becomes increasingly global. This article summarizes some of the challenges in supplement science and provides a case study of research at the Office of Dietary Supplements at the National Institutes of Health, USA, along with some resources it has developed that are available to all scientists. It includes examples of some of the regulatory challenges faced and some resources for those who wish to learn more about them.

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“…However, the efficacy of such ‘NO-boosting’ supplements (e.g. amino acids or plant extracts) is still controversial, due to the lack of evidence for increased blood flow and/or volume after their application [ 5–11 ].…”

Section: Introductionmentioning

confidence: 99%

New perspectives for investigating muscular perfusion response after dietary supplement intake: an exploratory, randomized, double-blind, placebo-controlled crossover trial in healthy young athletes using contrast-enhanced ultrasound (CEUS)

Bürkle

Doll

Neide

et al. 2022

Journal of the International Society of Sports Nutrition

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Background Various dietary supplements have been reported to enhance muscular perfusion in athletes practicing resistance training, especially through modulation of nitric oxide signaling. Objectives The aim of this study was therefore to investigate selected ‘NO-boosting’ supplements in a real-life setting i) to generate novel hypotheses and perfusion estimates for power calculation in view of a definitive trial and ii) to assess the feasibility of the study design with particular focus on the use of contrast-enhanced ultrasound (CEUS) for perfusion quantification. Methods Thirty young male athletes (24 ± 4 years) regularly practicing resistance training were enrolled in this three-arm, placebo(PL)-controlled crossover trial with ingestion of two commercially available supplements: an amino acid combination (AA) (containing 3 g of L-arginine-hydrochloride and 8 g of L-citrulline-malate) and 300 mg of a specific green tea extract (GTE). After intake, CEUS examinations of the dominant biceps brachii muscle were performed under resting conditions and following standardized resistance exercising. Quantitative parameters of biceps perfusion (peak enhancement, PE; wash-in perfusion index, WiPI) and caliber were derived from corresponding CEUS video files. Additionally, subjective muscle pump was determined after exercise. Results For PE, WiPI, and biceps caliber, the standard deviation (SD) of the within-subject differences between PL, AA, and GTE was determined, thereby allowing future sample size calculations. No significant differences between PL, AA, and GTE were observed for biceps perfusion, caliber, or muscle pump. When comparing resting with post-exercise measurements, the increase in biceps perfusion significantly correlated with the caliber increase (PE: r = 0.266, p = 0.0113; WiPI: r = 0.269, p = 0.0105). Similarly, the biceps perfusion correlated with muscle pump in the post-exercise conditions (PE: r = 0.354, p = 0.0006; WiPI: r = 0.350, p = 0.0007). A high participant adherence was achieved, and the acquisition of good quality CEUS video files was feasible. No adverse events occurred. Conclusion Based on our novel examination protocol, CEUS seems to be feasible following higher-load resistance exercising and may be used as a new method for high-resolution perfusion quantification to investigate the effects of pre-exercise dietary supplementation on muscle perfusion and related muscle size dynamics.

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Safety and performance benefits of arginine supplements for military personnel: a systematic review

Cited by 11 publications

References 76 publications

Involvement of serotonergic pathways in gastric dysmotility induced by fat burning nutritional supplements in mice

Involvement of serotonergic pathways in gastric dysmotility induced by fat burning nutritional supplements in mice

Dietary Supplements: Regulatory Challenges and Research Resources

New perspectives for investigating muscular perfusion response after dietary supplement intake: an exploratory, randomized, double-blind, placebo-controlled crossover trial in healthy young athletes using contrast-enhanced ultrasound (CEUS)

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