Safety and immunogenicity of hepatitis B vaccine administered into ventrogluteal vs. anterolateral thigh sites in infants: A randomised controlled trial

Junqueira, Ana Luiza Neto; Tavares, Viviane Rodrigues; Martins, Regina Maria Bringel; Frauzino, Kamilla Vêncio; Silva, Ágabo Macedo da Costa e; Minamisava, Ruth; Teles, Sheila Araújo

doi:10.1016/j.ijnurstu.2010.01.009

Cited by 20 publications

(28 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…, Junqueira et al . ). The observed muscle thickness in our study at the ventrogluteal site is consistent with the literature (Cook & Murtagh ).…”

Section: Discussionmentioning

confidence: 97%

“…In addition, recent literature has reported that the ventrogluteal area can be an alternative site for IM injections in children ≤12 months of age (Cook & Murtagh , , Junqueira et al . ). However, only scant examples of research‐based evidence were found regarding the use of the ventrogluteal site in infants and toddlers.…”

Section: Introductionmentioning

confidence: 97%

“…Although the anterolateral thigh and the deltoid muscle are the two anatomical sites recommended for routine intramuscular injections in children, varying information exists in clinical guidelines, in research results and fundamental textbooks as regards what the most suitable injection sites are in children at 3 years old. In addition, recent literature has reported that the ventrogluteal area can be an alternative site for IM injections in children ≤12 months of age (Cook & Murtagh 2002, 2003, Junqueira et al 2010. However, only scant examples of research-based evidence were found regarding the use of the ventrogluteal site in infants and toddlers.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Is the ventrogluteal site suitable for intramuscular injections in children under the age of three?

Güneş

Ceylan

Bayındır

2015

Journal of Advanced Nursing

View full text Add to dashboard Cite

show abstract

“…, Junqueira et al . ). The observed muscle thickness in our study at the ventrogluteal site is consistent with the literature (Cook & Murtagh ).…”

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Is the ventrogluteal site suitable for intramuscular injections in children under the age of three?

Güneş

Ceylan

Bayındır

2015

Journal of Advanced Nursing

View full text Add to dashboard Cite

show abstract

“…There were a number of studies evaluating the immune outcomes of different vaccination schedules, different recombinant vaccines in infants of HBsAg positive mothers [7], [11], [19], [36], [37], but few studies evaluated whether maternal HBV infection status would influence the response to HB immunization in those infants. Our results showed that maternal HBeAg status and serum HBV DNA levels did not influence the response to HBV immunization in infants of HBsAg-positive mothers.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Hepatitis B Vaccine Combined with Two-Dose Hepatitis B Immunoglobulin on Infants Born to HBsAg-Positive Mothers

et al. 2011

View full text Add to dashboard Cite

BackgroundDespite the use of hepatitis B (HB) vaccine and hepatitis B immunoglobulin (HBIG), a portion of infants are still non- or low-responders, or even immunoprophylaxis failure. We aimed to determine the immune response in the infants from the mothers being positive for hepatitis B surface antigen (HBsAg), by which the infants received three doses of HB vaccine in combination with two-dose 200 IU HBIG injections.MethodsIn this retrospective study, 621 infants from HBsAg-positive mothers in Beijing YouAn Hospital between January 2008 and December 2009 were included. All the infants were given three doses of 10 µg HB vaccine (at 0, 1 and 6 months of age) and two-dose of 200 IU HBIG (at birth and in 2 weeks of age). Serum HBsAg and antibody to HBsAg (anti-HBs) in all the infants were determined at 7 months of age.ResultsOf the 621 infants, 2.9% were immunoprophylaxis failure (positive for HBsAg), 1.4% were non-responders (anti-HBs undetectable), 95.7% were responders. The 594 responders could be categorized into three subsets, 22 were 10 to 99 IU/L for anti-HBs levels, 191 were 100 to 999 IU/L, and 381 were ≥1000 IU/L. The immunoprophylaxis failure rate was at 0% and 5.2% for the infants of HBeAg-negative and HBeAg-positive mothers(P<0.001). Infants from mothers with detectable HBV DNA had higher incidence of immunoprophylaxis failure than those of mothers without detectable HBV DNA (P = 0.002). The factors including gender, birth weight, gestation weeks, the rates of maternal HBeAg-positive, and detectable HBV DNA did not contribute to the no response to HB vaccination.ConclusionsThrough vaccination by three doses of HB and two-dose of HBIG, majority of the infants (95.7%) achieved a protective level of anti-HBs at 7 months of age. Maternal HBeAg-positive and HBV DNA detectable were associated with the immunoprophylaxis failure, but not contribute to the non- or low-response to HB vaccination.

show abstract

“…Another study by Junqueira et al. () reported that VG site was suitable in infants, particularly for injection of hepatitis B vaccination.…”

Section: Introductionmentioning

confidence: 99%

Investigation of suitability of ventrogluteal site for intramuscular injections in children aged 36 months and under

Atay

Kurt

Akkaya

et al. 2017

Specialist Pediatric Nursing

View full text Add to dashboard Cite

show abstract

Safety and immunogenicity of hepatitis B vaccine administered into ventrogluteal vs. anterolateral thigh sites in infants: A randomised controlled trial

Cited by 20 publications

References 21 publications

Is the ventrogluteal site suitable for intramuscular injections in children under the age of three?

Is the ventrogluteal site suitable for intramuscular injections in children under the age of three?

Protective Effect of Hepatitis B Vaccine Combined with Two-Dose Hepatitis B Immunoglobulin on Infants Born to HBsAg-Positive Mothers

Investigation of suitability of ventrogluteal site for intramuscular injections in children aged 36 months and under

Contact Info

Product

Resources

About