Safety and Feasibility of Laparoscopic Radical Cystectomy for the Treatment of Bladder Cancer

Aboumarzouk, Omar; Hughes, O. D. M.; Narahari, Krishna; Drewa, Tomasz; Chłosta, Piotr; Kynaston, Howard

doi:10.1089/end.2013.0084

Cited by 29 publications

(30 citation statements)

References 45 publications

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“…The survival rate of LRC in the present study was almost comparable to that of MIRC (LRC or RARC) or that of ORC, as previously reported . In accordance with our results, systemic reviews and recent randomized trials for RARC have shown that oncological outcomes of MIRC are equivalent to those of ORC . Similar to previous reports, 5‐year relapse‐free survival, cancer‐specific survival and overall survival were stratified into pT and pN, and the presence or absence of lymph node dissection, pT and pN were significant factors associated with recurrence on multivariate analysis.…”

Section: Discussionsupporting

confidence: 91%

“…Radical cystectomy is a standard treatment for locally muscle‐invasive bladder cancer and aggressive, non‐muscle‐invasive bladder cancer that is refractory to conservative treatment, but it is associated with a significant rate of complications . Therefore, MIRC, such as LRC and RARC, have been introduced to reduce postoperative complications . Indeed, MIRC is becoming popular for invasive and high‐grade bladder cancer.…”

Section: Introductionmentioning

confidence: 99%

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Oncological outcomes and recurrence patterns after laparoscopic radical cystectomy for bladder cancer: A Japanese multicenter cohort

et al. 2020

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Objective To investigate oncological outcomes and recurrence patterns after laparoscopic radical cystectomy for bladder cancer in a Japanese multicenter cohort, and to explore the risk factors associated with recurrences due to tumor dissemination. Method Laparoscopic radical cystectomies carried out at 10 institutions were included in this retrospective study. Multivariate analyses were carried out to identify the clinical parameters associated with overall recurrences together with specific recurrence types. Kaplan–Meier curves were created to elucidate time to recurrence and survival. Results A total of 411 patients were included after the final analysis. Postoperative pathology was T2 or higher in 196 patients (48%), and lymph node metastasis was present in 46 patients (11%). The median follow‐up period was 23 months, and the 2‐year recurrence‐free and cancer‐specific survival rates were 71.0% and 84.7%, respectively. The recurrence sites involved distant metastasis in 75 patients (18%), local recurrence in 52 patients (13%) and urinary tract recurrence in eight patients (2%). When local recurrence at the cystectomy bed (28 patients; 7%) and abdominal recurrence including peritoneal carcinomatosis or port site recurrence (17 patients; 4%), which might be caused by tumor dissemination, were combined into a single group, prolonged surgical time was a significant risk factor, in addition to high pathological stage (T3–4 and/or positive lymph nodes), positive surgical margins, and variant histology by both univariate and multivariate analyses. Conclusions Our study findings suggest that recurrences after laparoscopic radical cystectomy might be caused by tumor dissemination, and attention should be paid to avoid prolonged surgical time in laparoscopic radical cystectomy.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Oncological outcomes and recurrence patterns after laparoscopic radical cystectomy for bladder cancer: A Japanese multicenter cohort

et al. 2020

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“…They demonstrated that LRC was superior to ORC in perioperative outcomes, including EBL, blood transfusion rate, and analgesic requirement and there was no major difference in oncologic outcomes between LRC and ORC group. Tang et al [15] and Aboumarzouk et al [16] have also confirmed efficacy and safety of LRC by meta-analysis. With the continuous maturation of laparoscopic technology, robot-assisted radical cystectomy has become a treatment way for bladder cancer and its clinical feasibility has been recognized by more and more doctors [11].…”

Section: Discussionmentioning

confidence: 90%

Laparoscopic versus open radical cystectomy for patients with bladder cancer over 75-year-old: a prospective randomized controlled trial

Chen

Zhou

2017

Oncotarget

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The aim of this study was to compare the morbidity, mortality, oncological results and quality of life between laparoscopic radical cystectomy (LRC) and open radical cystectomy (ORC) in the elderly patients over 75 years old. Between January 2012 and January 2015, 60 patients were recruited into this study, who were randomly assigned in a 1:1 ratio to either LRC or ORC group. Baseline patient characteristics, pathological factors, operative and postoperative characteristics, postoperative complications and survival data were retrospectively collected, analyzed and compared between the two groups. Patients in LRC group and ORC group had comparable baseline characteristics and pathological factors (all P > 0.05). LRC group required longer operative time (408.2 ± 76.9 vs. 311.7 ± 65.3 min, P = 0.000) and had less EBL (621.6 ± 100.7 vs. 1088.5 ± 109.4 ml, P = 0.000) compared with ORC group. The incidence of infection and ileus within 90 days after surgery in ORC group was significantly higher than LRC group(6.9% vs. 28.6%, P = 0.041; 3.4% vs. 25%, P = 0.025). At a median follow-up of 28 months (range 12–48 months), the survival analysis showed that there were no significant differences between the LRC and ORC groups in overall survival (log-rank χ2 = 0.122; P = 0.726), or progress-free survival (log-rank χ2 = 0.153; P = 0.696). In conclusion, this study confirmed that LRC could achieve similar tumor treatment efficacy compared to ORC, with fewer perioperative complications and less blood loss. We suggest that LRC should be considered as the primary intervention for patients aged over 75 years old with muscle invasive bladder cancer or non-muscle invasive bladder cancer with high risk factors.

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“…9 Despite these limitations, this approach has been shown to be safe and effective in experienced hands. [10][11][12][13] Robotic surgery has recently gained popularity, threatening to replace select open and laparoscopic procedures. The purported advantages of robotic surgery over laparoscopic surgery are increased maneuverability, improved vision with ten times magnification, enhanced endo-wrist dexterity, tremor elimination, and a shorter learning curve.…”

Section: Introductionmentioning

confidence: 99%

Robotic or Open Radical Cystectomy, Which Is Safer? A Systematic Review and Meta-Analysis of Comparative Studies

Ishii¹,

Prasad

Stolzenburg

et al. 2014

Journal of Endourology

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Safety and Feasibility of Laparoscopic Radical Cystectomy for the Treatment of Bladder Cancer

Abstract: In experienced hands, LRC is a feasible and safe alternative to ORC with less blood loss, transfusion and analgesic requirement, shorter lengths of hospital stay, and less complications. LRC does, however, have longer operative times.

Cited by 29 publications

References 45 publications

Oncological outcomes and recurrence patterns after laparoscopic radical cystectomy for bladder cancer: A Japanese multicenter cohort

Oncological outcomes and recurrence patterns after laparoscopic radical cystectomy for bladder cancer: A Japanese multicenter cohort

Laparoscopic versus open radical cystectomy for patients with bladder cancer over 75-year-old: a prospective randomized controlled trial

Robotic or Open Radical Cystectomy, Which Is Safer? A Systematic Review and Meta-Analysis of Comparative Studies

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