Safety and efficacy of hydroxy analogue of methionine and its calcium salt (ADRY+®) for all animal species

Additives, Efsa Panel on; Rychen, Guido; Aquilina, Gabriele; Azimonti, Giovanna; Bampidis, Vasileios; Bastos, Maria de Lourdes; Bories, Georges; Chesson, Andrew; Cocconcelli, Pier Sandro; Flachowsky, Gerhard; Gropp, Jürgen; Kolar, Boris; Kouba, Maryline; López‐Alonso, Marta; Puente, Secundino López; Mantovani, Alberto; Mayo, Baltasar; Ramos, Fernando; Saarela, Maria; Villa, Roberto Edoardo; Wester, Pieter; Costa, Lucio G.; Dierick, Noël; Leng, Lubomir; Tarrés‐Call, Jordi; Wallace, Robert John

doi:10.2903/j.efsa.2018.5198

Cited by 6 publications

(1 citation statement)

References 45 publications

(43 reference statements)

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“…Basically, two products for balancing dietary methionine are commercially available: DL-methionine (DLM) and liquid methionine hydroxyl analoguefree acid (MHA-FA). Research suggests that they differ in their biological activity, which is confirmed in the assessment performed by EFSA in numerous publications as 75% on an equimolar basis [6,7]. Among other causes, a lack of methionine is discussed as a predisposing factor for footpad dermatitis (FPD), hepatic lipidosis and oxidative stress [8][9][10][11].…”

Section: Introductionmentioning

confidence: 96%

Evaluation of Methionine Sources in Protein Reduced Diets for Turkeys in the Late Finishing Period Regarding Performance, Footpad Health and Liver Health

et al. 2021

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Footpad dermatitis and hepatic lipidosis are health problems in fattening turkeys where a positive influence of higher methionine content in feed is discussed. The effects of the methionine supplements DL-methionine (DLM) and liquid methionine hydroxyl analogue free acid (MHA-FA) under the aspect of low protein diets were investigated in this study based on performance parameters, footpad health, liver health and oxidative stress. In this study, 80 female turkeys (B.U.T. Big 6) of 63 day-old, were randomly assigned to four groups characterising a 2 × 2 factorial design with five replicates each over five weeks. The groups were fed with diets differing in methionine source (DLM vs. MHA-FA, assuming a biological activity of MHA-FA of 65%) and crude protein content (15% vs. 18%) for 35 days. The results showed no significant interactions between the protein content and methionine source. Strong protein reduction significantly impaired water intake, feed intake, weight gain and feed conversation ratio, but improved footpad health. DLM and MHA-FA addition had no significant effect on weight gain, crude fat and protein contents in the liver, but DLM resulted in a significant increase in livers antioxidative capacity compared to MHA-FA. Although the protein reduction resulted in reduced performance, the study showed that MHA-FA can be replaced by DLM in a 100:65 weight ratio without compromising performance but with certain advantages in the antioxidative capacity of the liver.

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Section: Introductionmentioning

confidence: 96%

Evaluation of Methionine Sources in Protein Reduced Diets for Turkeys in the Late Finishing Period Regarding Performance, Footpad Health and Liver Health

et al. 2021

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Reply to: “Absorption of methionine sources in animals—is there more to know?” — Yes, there is more to know!

Lemme¹,

Dorigam²,

Mack³

2023

Animal Nutrition

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Supplemental methionine exerted chemical form-dependent effects on antioxidant status, inflammation-related gene expression, and fatty acid profiles of broiler chicks raised at high ambient temperature1

Liu

Magnuson

Sun

et al. 2019

Journal of Animal Science

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This study was to explore metabolic effects of two forms and concentrations of supplemental methionine in grower and finisher diets for broiler chickens raised at high temperature. Male Cornish cockerel chicks (total = 360, day-old) were divided into four groups (10 pens/treatment, 9 chicks/pen) and fed with 100% or 130% required methionine in the diets as DL-methionine (DL-MET) or 2-hydroxy-4-(methylthio)butanoate (HMTBA). The room was maintained at 4 to 13 °C above the suggested thermoneutral temperature. The higher concentration of both DL-MET and HMTBA enhanced (P < 0.05) hepatic GSH concentrations of the growers and plasma ferric reducing ability of the finishers. The DL-MET-fed growers had greater (P < 0.05%) muscle GSH and hepatic unsaturated fatty acid concentrations than those fed HMTBA. Expression of inflammation-related genes in the liver of finishers was affected (P < 0.05) by interaction effects of the methionine form and concentration. In conclusion, effects of the extra methionine supplementation on the high ambient temperature-related metabolic responses of broilers varied with their age and(or) tissue and the methionine form.

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Safety and efficacy of hydroxy analogue of methionine and its calcium salt (ADRY+®) for all animal species

Cited by 6 publications

References 45 publications

Evaluation of Methionine Sources in Protein Reduced Diets for Turkeys in the Late Finishing Period Regarding Performance, Footpad Health and Liver Health

Evaluation of Methionine Sources in Protein Reduced Diets for Turkeys in the Late Finishing Period Regarding Performance, Footpad Health and Liver Health

Reply to: “Absorption of methionine sources in animals—is there more to know?” — Yes, there is more to know!

Supplemental methionine exerted chemical form-dependent effects on antioxidant status, inflammation-related gene expression, and fatty acid profiles of broiler chicks raised at high ambient temperature1

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