Safety and efficacy of combined use of propofol and etomidate for sedation during gastroscopy

Chen, Lingyuan; Liang, Xueqing; Tan, Xinmei; Wen, Haibin; Jiang, Junsong; Li, Yan

doi:10.1097/md.0000000000015712

Cited by 26 publications

(20 citation statements)

References 37 publications

(56 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous study has shown that the physical and chemical properties of the admixture of propofol and etomidate have not changed, it can be safely used in clinical anesthesia, and its compatibility is stable. [ 11 ] Many researches have confirmed that the admixture of propofol and etomidate not only maintains the stability of the respiratory system of patients, but also reduces the incidence of adverse reactions such as injection pain, nausea and vomiting, [ 12 ] hypoxemia, [ 13 ] hypotension and oxygen desaturation. [ 14 ]…”

Section: Discussionmentioning

confidence: 99%

“…Previous study has shown that when etomidate is used for induction of anesthesia, the incidence of muscle spasm is as high as 50% to 80%, and it is dose-dependent. [ 12 ] Muscle spasm causes postoperative myalgia, increases blood potassium and other adverse reactions, especially increases gastrointestinal motility after muscle tremor, leading to an increased risk of vomiting and aspiration.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical observation of the combined use of propofol and etomidate in painless gastroscopy

Zhu

et al. 2020

Medicine

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical observation of the combined use of propofol and etomidate in painless gastroscopy

Zhu

et al. 2020

Medicine

View full text Add to dashboard Cite

show abstract

“…If substantial heterogeneity occurred (I 2 > 50% or p < 0.05), a random effects model was used to calculate the pooled MD (Chen et al 2019). Publication/reporting biases were visually assessed using funnel plots.…”

Section: Discussionmentioning

confidence: 99%

Panax notoginseng preparations as adjuvant therapy for diabetic kidney disease: a systematic review and meta-analysis

Tang

Huang

Jiang

et al. 2020

Pharmaceutical Biology

Self Cite

View full text Add to dashboard Cite

Context: Panax notoginseng (Burk.) F.H. Chen (Araliaceae) preparations (PNP) are traditional Chinese medicines used as adjuvant therapeutics for diabetic kidney disease (DKD). Objective: To systematically review the efficacy of PNP as adjunct DKD therapy, including their effects on kidney function, serum lipid levels and fasting blood glucose levels. Methods: The databases PubMed, Embase, Medline, Cochrane Library, CINAHL, China Biology Medicine disc, Wanfang, VIP and China National Knowledge Infrastructure were systematically searched from the date of their inception until May 2019. Panax notoginseng, Panax notoginseng saponins, Lulutong, Xueshuantong and Xuesaitong were the key terms searched. Randomized controlled trials (RCTs) comparing the combined use of PNP and conventional medicines (CM) versus CM for DKD were included. Data were pooled using random or fixed effect models depending on heterogeneity. Results: In total, 24 RCTs involving 1918 participants were analysed. Adjunct PNP with CM was associated with reduction of albuminuria (MD-26.89 mg, 95% CI:-33.35 to-20.42), proteinuria (MD-0.32 g/24 h, 95% CI:-0.36 to-0.27), serum creatinine (MD-4.52 lmol/L, 95% CI:-8.71 to-0.32), total cholesterol (MD-1.56 mmol/L, 95% CI:-2.33 to-0.78), triglycerides (TG) (MD-0.56 mmol/L, 95% CI:-0.80 to-0.31) and low-density lipoprotein cholesterol (MD-0.94 mmol/L, 95% CI:-1.49 to-0.40) compared with CM. Conclusions: This is the first meta-analysis investigating adjuvant PNP therapy for DKD. PNP apparently exerted beneficial effects on kidney function and improved the metabolism of serum lipids by CM. Further, well-conducted, high-quality trials on DKD patients are needed to provide high-quality evidence.

show abstract

“…A clear surgical field becomes the most basic requirement that minimally invasive surgeries must meet. 9 In hand and foot surgeries, the application of tourniquets can meet the requirements of surgeons for clarity of surgical field, but collateral injury occurs from limb I/R. 10 , 11 Earlier studies showed that I/R of the hind limbs in rats can lead to lung injury at distance sites.…”

Section: Discussionmentioning

confidence: 99%

Effects of cyclosporin A pre-treatment combined with etomidate post-treatment on lung injury induced by limb ischemia-reperfusion in rats

Zou

Sun

2020

J Int Med Res

View full text Add to dashboard Cite

Objectives To investigate the influence of cyclosporin A (CsA) pre-treatment and etomidate (ETO) post-treatment on lung injury induced by limb ischemia-reperfusion (I/R) in rats. Methods Rats were randomly divided into five groups: sham, I/R, I/R+CsA, I/R+ETO, and I/R+CsA+ETO. Limb I/R lung injury was established by bilateral clamping of the femoral arteries for 2 hours. Following reperfusion for 3 hours, blood gas analysis was performed. Pathological changes were assessed using immunohistochemistry. The apoptosis index (AI) and wet/dry weight ratio (W/D) were calculated. Levels of Fas protein and FasL mRNA were assessed by western blotting and RT-PCR, respectively. Tumor necrosis factor (TNF)-α and interleukin (IL)-1β were detected by ELISA. Results I/R resulted in decreased PaO2 but increased AI, W/D, Fas, FasL mRNA, TNF-α and IL-1β. Scattered punctate apoptosis and necrosis were observed by immunohistochemistry. Compared with the I/R group, the I/R+ETO and I/R+CsA groups showed increased SpO2, decreased AI, W/D, Fas, FasL mRNA, TNF-α and IL-1β, and decreased numbers of apoptotic and necrotic cells. Combined treatment with CsA+ETO resulted in more dramatic changes in these parameters. Conclusions ETO post-treatment and CsA pretreatment reduced lung injury induced by limb I/R in rats. The mechanism may be related to synergistic inhibition of Fas/FasL signaling.

show abstract

Safety and efficacy of combined use of propofol and etomidate for sedation during gastroscopy

Abstract: Supplemental Digital Content is available in the text

Cited by 26 publications

References 37 publications

Clinical observation of the combined use of propofol and etomidate in painless gastroscopy

Clinical observation of the combined use of propofol and etomidate in painless gastroscopy

Panax notoginseng preparations as adjuvant therapy for diabetic kidney disease: a systematic review and meta-analysis

Effects of cyclosporin A pre-treatment combined with etomidate post-treatment on lung injury induced by limb ischemia-reperfusion in rats

Contact Info

Product

Resources

About