Safe and sustainable plasmapheresis

Pink, Joanne; Bell, Barbara; Kotsiou, George; Wright, S.; Thyer, J.

doi:10.1111/voxs.12387

Cited by 1 publication

(2 citation statements)

References 12 publications

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“…Their data are consistent with that published by Pink et al [11] in Figure 1. These data demonstrated that for both males and females, the VVR rate was highest at the 13% TBV collection tier and progressively reduced as the TBV collection tier increased from 16% to 18%.…”

Section: Vvrs and Plasma Volume Collection Limitssupporting

confidence: 94%

“…An upper collection volume limit is required for both physiological and manufacturing reasons (i.e., blood bag limits). However, research [9,11,14] suggests that there are individuals who can tolerate higher collection volumes than others. Some donors develop symptoms before collection commencement because of anxiety or pain precipitating a VVR.…”

Section: Discussionmentioning

confidence: 99%

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A donor safety evidence literature review of the short‐ and long‐term effects of plasmapheresis

Hoad,

Castrén,

Norda

et al. 2023

Vox Sanguinis

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Many blood establishments are expanding plasmapheresis collection capacity to achieve increasing plasma for fractionation volume targets, driven by immunoglobulin product demand. Some adverse events occur in both apheresis and whole blood collection, such as venepuncture‐related trauma and vasovagal reactions. Others are specifically related to the apheresis procedure, such as citrate reactions, haemolysis, infiltration and air embolism. Whilst plasmapheresis procedures are generally well tolerated, theoretical longer term donor health considerations, such as the effects on donor plasma protein levels, bone mineral density, iron deficiency and malignancy also require consideration. An evidence‐based framework that supports a safe and sustainable increase in the collection of plasma is essential. Our review demonstrates a lack of high‐quality evidence on risks and outcomes specifically in plasmapheresis. Whilst conservative procedural controls and donor harm minimization policies will mitigate risk, high‐quality evidence is needed to facilitate practice change that is safe and sustainable and maximizes the potential of individual donor differences.

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Section: Vvrs and Plasma Volume Collection Limitssupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%