Safe and Effective Chin Augmentation With the Hyaluronic Acid Injectable Filler, VYC-20L

Beer, Kenneth; Kaufman‐Janette, Joely; Bank, David; Biesman, Brian S.; Dayan, Steven H.; Kim, William; Chawla, Smita; Schumacher, Andrew

doi:10.1097/dss.0000000000002795

Cited by 29 publications

(31 citation statements)

References 22 publications

(5 reference statements)

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“…It mainly encompasses primarily nonpathogenic species that colonize the healthy skin or mucous membranes (eg, Cutibacterium acnes, Streptococcus oralis, Staphylococcus epidermidis), which was confirmed via polymerase chain reaction tests. [33][34][35] It is frequently difficult to confirm the infective agent in cultures due to their distinct slow-growing character and the fact that they are known as variants of small colonies. Moreover, their metabolism may be decelerated in the biofilm, which facilitates the avoidance of antibiotic influence.…”

Section: Biofilm Componentsmentioning

confidence: 99%

“…Such bacteria may remain dormant for many years and then be activated by external factors and provoke a response. [35][36][37] Macrophages and giant cells are usually present in the vicinity of those microorganisms. They may be rapidly activated and induce inflammatory reactions.…”

Section: Biofilm Componentsmentioning

confidence: 99%

“…Moreover, their metabolism may be decelerated in the biofilm, which facilitates the avoidance of antibiotic influence. 35 , 36 Furthermore, the ability to form the extracellular matrix of exopolysaccharides, which also includes HA, is a preventive factor in terms of phagocytosis. Such bacteria may remain dormant for many years and then be activated by external factors and provoke a response.…”

Section: Factors Influencing the Immunogenicity Of Ha Productsmentioning

confidence: 99%

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The Immunogenicity of Hyaluronic Fillers and Its Consequences

Owczarczyk‐Saczonek¹,

Zdanowska²,

Wygonowska³

et al. 2021

CCID

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Hyaluronic acid (HA) is a glycosaminoglycan, a natural component of the extracellular matrix. The identical structure of the molecule in all living organisms is its main advantage, as it translates into the minimal probability of immunogenicity. Therefore, it is the closest to the ideal preparation used as a filler, due to its biocompatibility and stability at the site of implantation. This paper includes the discussion of the potential mechanisms of adverse immune reactions to HA along with the mechanisms of reaction following vaccinations against SARS-CoV-2. Based on the literature, we tried to systematize adverse immune reactions with systemic manifestations to HA. The occurrence of unpredictable reactions to hyaluronic acid indicates that they may not be treated as neutral or non-allergenic. The modifications of the chemical structure of HA, additives and individual tendencies in a patient may be the cause of unpredictable reactions, leading to serious health consequences. Preparations of unknown origin, poorly purified, or including bacterial DNA are particularly dangerous. Therefore, long-lasting follow-up of the patient and the selection of a preparation approved by the FDA or EMA are of high importance. Patients are often unaware of the consequences of cheaper procedures performed by persons without suitable knowledge with the use of unregistered products, so the public should be educated and legal regulations should be introduced.

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Section: Biofilm Componentsmentioning

confidence: 99%

Section: Biofilm Componentsmentioning

confidence: 99%

Section: Factors Influencing the Immunogenicity Of Ha Productsmentioning

confidence: 99%

See 1 more Smart Citation

The Immunogenicity of Hyaluronic Fillers and Its Consequences

Owczarczyk‐Saczonek¹,

Zdanowska²,

Wygonowska³

et al. 2021

CCID

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“…Several case series of lower jaw nonsurgical reshaping with the use of fillers are published in medical literature, even though most of them are not focused on the treatment of the aging mandible [14,[16][17][18]. In a recent paper, Bertossi et al described their experience in the nonsurgical definition of the chin and jawline in younger adults, using a grid system approach.…”

Section: Discussionmentioning

confidence: 99%

Nonsurgical Reshaping of the Lower Jaw With Hyaluronic Acid Fillers: A Retrospective Case Series

Rauso

Rugge

Chirico

et al. 2022

Dermatol Pract Concept

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Introduction: Non-surgical aesthetic treatments of the lower face are increasingly in demand, particularly aimed to restore facial youth following the changes secondary to a progressive resorption of facial skeleton and atrophy of facial fat compartments, which give the perception of a descent face. Objective: The aim of this research is to describe non-surgical reshaping of aged lower jaw by means of hyaluronic acid fillers. Methods: A retrospective analysis of data from adult female patients undergoing treatment of the lower third of the face with hyaluronic acid injections was performed. Injection techniques, relevant anatomy of the anatomical area and rheological properties of the fillers to be used are highlighted. Results: Thirty-six consecutive patients were enrolled (100% female; mean age, 45.7 years). A minimum of 4 vials, up to 7, of hyaluronic acid filler, were injected in order to achieve the desired results. Visual analog scale (VAS) was used to assess patient satisfaction. Thirty-two patients (88.8%) rated their appearance post-treatment with a satisfaction score ranging between 85 and 100%. Total absence of ecchymosis and/or swelling in the early post-operative days has been highlighted. There were no cases of infection, paresthesia, hematoma or necrosis. Conclusions: Jaw line remodeling with hyaluronic acid fillers, in patients not willing to undergo surgery, seems to be a viable option for ameliorating the definition of the lower third of the face, although it is mandatory to perform multi-layer injections using fillers with different rheological properties.

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“…Hence, by defocusing the attention from a main defect and adopting a global rejuvenation approach, subject satisfaction was achieved with a limited amount of filler. 24,25 The reality of routine practice, where the injector is limited by patient finances, may further explain these small injection volumes. Primary Endpoint: Proportion (with 95% CI) of "improved" or "much improved" GAIS at Month 3 (PI and subject assessment)…”

Section: Discussionmentioning

confidence: 99%