2012
DOI: 10.1016/s0016-5085(12)61364-x
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Sa1930 Predictive Factors for Colectomy in Severe Corticosteroid (CS) Refractory Ulcerative Colitis (UC) Treated With Infliximab (IFX)

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“…Gibson et al observed that a serum albumin concentration > 22 g/L at infliximab initiation, which was present in more than half (26/50) of the acute severe UC patients in their study, was associated with a reduced colectomy rate (relative risk: 0.84, 95% CI: 0.75–0.95, P = 0.003) . Sambuelli et al and Lees et al reported higher optimal cut‐offs (30 g/L and 34 g/L, respectively), with a colectomy hazard ratio of 3.15 (95% CI 1.15 to 8.62, P = 0.0026) at a mean follow‐up of 19.4 months and 12.0 (95% CI 1.28–112.7) at day 90, respectively, below these concentrations . .…”
Section: Resultsmentioning
confidence: 87%
“…Gibson et al observed that a serum albumin concentration > 22 g/L at infliximab initiation, which was present in more than half (26/50) of the acute severe UC patients in their study, was associated with a reduced colectomy rate (relative risk: 0.84, 95% CI: 0.75–0.95, P = 0.003) . Sambuelli et al and Lees et al reported higher optimal cut‐offs (30 g/L and 34 g/L, respectively), with a colectomy hazard ratio of 3.15 (95% CI 1.15 to 8.62, P = 0.0026) at a mean follow‐up of 19.4 months and 12.0 (95% CI 1.28–112.7) at day 90, respectively, below these concentrations . .…”
Section: Resultsmentioning
confidence: 87%