Sa1527 DEVELOPMENT OF A LONG-ACTING DIRECT-ACTING ANTIVIRAL SYSTEM FOR HEPATITIS C VIRUS TREATMENT IN A SWINE MODEL

Verma, Malvika; Chu, Jacqueline N.; Salama, John A. F.; Faiz, Mohammed T.; Gwynne, Feyisope Ew Declan; Lopes, Aaron; Hess, Kaitlyn; Soares, Vance; Steiger, Christoph; McManus, R J; Koeppen, Ryan; Hua, Tiffany; Collins, Joy; Tamang, Siddartha; Ishida, Keiko; Miller, Jonathan B.; Katz, Stephanie; Slocum, Alexander H.; Sulkowski, Mark S.; Thomas, David L.; Langer, Robert; Traverso, Giovanni

doi:10.1016/s0016-5085(20)33972-x

Cited by 3 publications

(2 citation statements)

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“…However, the relatively short timescale of release from expandable PVA-based DDSs was found to be an issue, especially when dealing with chronic pathologies that would benefit from long-lasting retention at the target site. Indeed, improvement of patient compliance and of treatment efficacy, through reduced dosing frequency and fluctuations in drug plasma concentrations, were indicated as key elements in the development of intragastric DDSs intended to treat a range of diseases having great social interest and economic impact, such as acquired immunodeficiency syndrome and hepatitis C [11,13,[35][36][37]. For this purpose, an at least 8-h prolonged-release performance would be required from gastro-retentive DDSs [2,6,10].…”

Section: Introductionmentioning

confidence: 99%

Expandable Drug Delivery Systems Based on Shape Memory Polymers: Impact of Film Coating on Mechanical Properties and Release and Recovery Performance

et al. 2022

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Retentive drug delivery systems (DDSs) are intended for prolonged residence and release inside hollow muscular organs, to achieve either local or systemic therapeutic goals. Recently, formulations based on shape memory polymers (SMPs) have gained attention in view of their special ability to recover a shape with greater spatial encumbrance at the target organ (e.g., urinary bladder or stomach), triggered by contact with biological fluids at body temperature. In this work, poly(vinyl alcohol) (PVA), a pharmaceutical-grade SMP previously shown to be an interesting 4D printing candidate, was employed to fabricate expandable organ-retentive prototypes by hot melt extrusion. With the aim of improving the mechanical resistance of the expandable DDS and slowing down relevant drug release, the application of insoluble permeable coatings based on either Eudragit® RS/RL or Eudragit® NE was evaluated using simple I-shaped specimens. The impact of the composition and thickness of the coating on the shape memory, swelling, and release behavior as well as on the mechanical properties of these specimens was thoroughly investigated and the effectiveness of the proposed strategy was demonstrated by the results obtained.

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Section: Introductionmentioning

confidence: 99%

Expandable Drug Delivery Systems Based on Shape Memory Polymers: Impact of Film Coating on Mechanical Properties and Release and Recovery Performance

et al. 2022

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“…Such strategies mainly involved mechanical/elastic deployment, shape memory effect and superelasticity [5,34,35]. By way of example, the unique superelastic behavior of nitinol was used for manufacturing a necklace-like device able to convey high drug dosages covering multiple weeks of treatment [36,37]. In the same way, by using shape memory polymers as feedstock material for 3D…”

Section: Introductionmentioning

confidence: 99%

Development of a multi-component gastroretentive expandable drug delivery system (GREDDS) for personalized administration of metformin

Uboldi,

Chiappa,

Rossi

et al. 2023

Expert Opinion on Drug Delivery

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Objectives Efficacy and compliance of type II diabetes treatment would greatly benefit from dosage forms providing controlled release of metformin in the upper gastrointestinal tract. In this respect, the feasibility of a new system ensuring stomach-retention and personalized release of this drug at its absorption window for multiple days was investigated. MethodsThe system proposed comprised of a drug-containing core and a viscoelastic umbrella-like skeleton, which were manufactured by melt-casting and 3D printing. Prototypes, alone or upon assembly and insertion into commercially-available capsules, were characterized for key parameters: thermo-mechanical properties, accelerated stability, degradation, drug release, deployment performance and resistance to simulated gastric contractions.Results Each part of the system was successfully manufactured using purposely-selected materials and the performance of final prototypes matched the desired one. This included: i) easy folding of the skeleton against the core in the collapsed administered shape, ii) rapid recovery of the cumbersome configuration at the target site, even upon storage and iii) prolonged release of metformin.Conclusions Composition, geometry and performance of the system developed in this work were deemed acceptable for stomach retention and prolonged as well as customizable release of metformin at its absorption window, laying promising bases for further development steps.

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Administration strategies and smart devices for drug release in specific sites of the upper GI tract

Uboldi

Melocchi

Moutaharrik

et al. 2022

Journal of Controlled Release

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Sa1527 DEVELOPMENT OF A LONG-ACTING DIRECT-ACTING ANTIVIRAL SYSTEM FOR HEPATITIS C VIRUS TREATMENT IN A SWINE MODEL

Cited by 3 publications

References 0 publications

Expandable Drug Delivery Systems Based on Shape Memory Polymers: Impact of Film Coating on Mechanical Properties and Release and Recovery Performance

Expandable Drug Delivery Systems Based on Shape Memory Polymers: Impact of Film Coating on Mechanical Properties and Release and Recovery Performance

Development of a multi-component gastroretentive expandable drug delivery system (GREDDS) for personalized administration of metformin

Administration strategies and smart devices for drug release in specific sites of the upper GI tract

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