Sa1444 Does Insulin Influence the Risk of Colon Adenomas and Colorectal Cancer? a Multicenter Look At a Minority Population

Lopez-Morra, Hernan; Linn, Sandar; Tejada, Juan; Ofori, Emmanuel; Guzmán, Luís; Sanivarapu, Sravanthi; Phan, Susan; Dhaliwal, Amaninder J.; Rodriguez, Katherine Sosa; Boora, Srinivasa R.; Shivji, Tariq; Sivakumar, Keithan; Sunkara, Tagore; Cullliford, Andrea N.; Anand, Sury

doi:10.1016/j.gie.2014.05.063

Cited by 3 publications

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“…Некоторые исследователи придают большое значение CD-133-маркеру, другие отрицают его специфическую роль в образовании колоректального рака. По исследованиям некоторых учёных, СD-133 положительные опухолевые клетки проявляют свою резистентность на химиолучевую терапию (ХЛТ) [19]. Экспрессия СD-133 чаще проявляется при раке ободочной кишки, чем при раке прямой кишки [20].…”

Section: результатыunclassified

Modifiable factors of development and recurrence of adenomatous colorectal polyps (literature review)

Gataullin,

Sakhabetdinov,

Valitov

et al. 2024

vmirvz

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Relevance. Adenomatous colorectal polyps are associated with a high risk of developing a malignant tumor. They are considered precancerous conditions and can lead to the development of colorectal cancer. To date, colorectal cancer ranks third in the world in frequency of occurrence among all malignant neoplasms.Objective. Improving the results of diagnosis and surgical treatment of patients with colorectal adenomatous neoplasms by identifying development factors and identifying risk groups for this nosology.Materials and methods. Analysis of literary data.Results. Among the factors leading to the development of colorectal polyps, it is worth noting a genetic predisposition, so by immunoblotting, PCR sequencing of the entire exome in cases of patients with familial dentate polyposis, rare variants of the germ line in the WNK2 gene were identified. Functional studies have shown that variants of the WINK2 germ line affect protein function in the context of the MAPK pathway, a molecular trait of this disease. Also, in the course of many domestic and foreign randomized clinical trials, the following modifiable factors for the development of adenomatous colorectal polyps were identified.Conclusion. The study revealed the factors of development and recurrence of colorectal neoplasms and identified risk groups for this nosology. The study revealed low compliance of patients with respect to changes in certain living conditions (the use of ethyl alcohol and products containing it, tobacco smoking, both active and passive, the fight against obesity and inactivity), which leads to recurrence and increases the risks of malignancy of colorectal polyps.

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Section: результатыunclassified

Modifiable factors of development and recurrence of adenomatous colorectal polyps (literature review)

Gataullin,

Sakhabetdinov,

Valitov

et al. 2024

vmirvz

View full text Add to dashboard Cite

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The link among microbiota, epigenetics, and disease development

El-Sayed

Aleya

Kamel

2021

Environ Sci Pollut Res

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Gender disparities in colorectal polyps

Safiyeva

2021

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Objective. The main objective of the research is the pathohistological consequences of colorectal adenomatosis polyps and their gender-based assessment. Gender and its connection with advanced colorectal displasia are the focus of the research study. Materials and methods. A retrospective analysis was conducted 100 patients. The age group of the patients in the research study mainly encompassed 19 to 65 aged patients. During the medical procedure, the gender distribution of the cases was determined as 60 males and 40 females respectively. Results. There is strong evidence for an association between gender and the risk of advanced colorectal neoplasia. The findings regarding the positive interrelation for gender and advanced colorectal neoplasia are consistent with other large colonoscopy-based studies. Conclusions. As a result of the study, we would like to emphasize that colorectal polyps are more common in men compared to in women

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Sa1444 Does Insulin Influence the Risk of Colon Adenomas and Colorectal Cancer? a Multicenter Look At a Minority Population

Cited by 3 publications

References 0 publications

Modifiable factors of development and recurrence of adenomatous colorectal polyps (literature review)

Modifiable factors of development and recurrence of adenomatous colorectal polyps (literature review)

The link among microbiota, epigenetics, and disease development

Gender disparities in colorectal polyps

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