S100A6 – New facts and features

Leśniak, Wiesława; Słomnicki, Łukasz P.; Filipek, Anna

doi:10.1016/j.bbrc.2009.10.150

Cited by 138 publications

(128 citation statements)

References 73 publications

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“…Indeed, other proteins in the 8505C cell proteomics are described as associated with the tumour growth and metastatic progression: i.e. the S100A6 [42] and LEG1, which, among several functions, is also considered a co-promoter of MMP-2 and MMP-9 expression [43] and therefore an enhancer of tumour invasion and metastasis. In support of this hypothesis is the observation that the 8505C cells produce and release into the medium a significant quantity of matrix metalloproteinases MMP-2 and MMP-9.…”

Section: Discussionmentioning

confidence: 99%

Differential proteomic and phenotypic behaviour of papillary and anaplastic thyroid cell lines

Musso

Cara

Albanese

et al. 2013

Journal of Proteomics

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Thyroid carcinomas account for a minority of all malignant tumours but, after those of the gonads, they represent the most common forms of endocrine cancers. They include several types, among which the papillary thyroid cancer (PTC) and the anaplastic thyroid cancer (ATC) are the best known. The two hystotypes display significant biological and clinical differences: PTC is a well differentiated form of tumour with a high incidence and a good prognosis, while the ATC is less frequent but represents one of the most aggressive endocrine tumours with morphological features of an undifferentiated type. To date, as far as we know, no conclusive studies, useful to design arrays of molecular markers, have been published illustrating the phenotypic and proteomic differences between these two tumours. The aim of this work was to perform a comparative analysis of two thyroid cancer cell lines, derived respectively from papillary (BCPAP) and anaplastic (8505C) thyroid carcinomas. The comparative analysis included cell behaviour assays and proteomic analysis by 2D-PAGE and mass spectrometry. IntroductionThe human thyroid gland is composed of a basic structural unit, the follicle, consisting of a monolayer of well polarized cells, the thyrocytes, responsible for the T3/T4 hormone secretion, and of other peripheral cells, the parafollicular C cells, responsible for the secretion of calcitonin. The presence within the follicle of stem cells, or remnants of embryonic cells, has been hypothesized as the target cells for tumour initiation. A thin extracellular matrix, which includes occasional fibroblasts and inflammatory cells, is peripheral to the follicle structure. Thyroid carcinomas account for 1-2% of all malignant tumours and, after those of the gonads, they represent the most common tumours of the endocrine system. The thyroid

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Section: Discussionmentioning

confidence: 99%

Differential proteomic and phenotypic behaviour of papillary and anaplastic thyroid cell lines

Musso

Cara

Albanese

et al. 2013

Journal of Proteomics

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“…Among many versatile functions of S100-A6, it has been mainly described to be involved in cytoskeleton rearrangement, as actin binding proteins, like annexins, have been identified as its target (see Supplemental Figure S5 at http://ajp.amjpathol.org). 47 In this context, interactions with tumor associated proteins such as annexin A2 and p53 may indicate a role of S100-A6 in cancer progression and metastasis. 48,49 Indeed, increased levels of S100-A6 have been found to be associated with metastasis or survival in colon and pancreatic cancer, respectively.…”

Section: Discussionmentioning

confidence: 99%

MALDI Imaging Identifies Prognostic Seven-Protein Signature of Novel Tissue Markers in Intestinal-Type Gastric Cancer

Balluff

Rauser

Meding

et al. 2011

The American Journal of Pathology

127

109

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Proteomics-based approaches allow us to investigate the biology of cancer beyond genomic initiatives. We used histology-based matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry to identify proteins that predict disease outcome in gastric cancer after surgical resection. A total of 181 intestinal-type primary resected gastric cancer tissues from two independent patient cohorts were analyzed. Protein profiles of the discovery cohort (n ‫؍‬ 63) were directly obtained from tumor tissue sections by MALDI imaging. A seven-protein signature was associated with an unfavorable overall survival independent of major clinical covariates. The prognostic significance of three individual proteins identified (CRIP1, HNP-1, and S100-A6) was validated immunohistochemically on tissue microarrays of an independent validation cohort (n ‫؍‬ 118). Whereas HNP-1 and S100-A6 were found to further subdivide early-stage (Union Internationale Contre le Cancer [UICC]-I) and late-stage (UICC II and III) cancer patients into different prognostic groups, CRIP1, a protein previously unknown in gastric cancer, was confirmed as a novel and independent prognostic factor for all patients in the validation cohort. The protein pattern described here serves as a new independent indicator of patient survival complementing the previously known clinical parameters in terms of prognostic relevance. These results show that this tissue-based proteomic approach may provide clinically relevant information that might be beneficial in improving risk stratification for gastric cancer patients.

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“…The targets of S100A6 include glyceraldehyde-3-phosphate dehydrogenase, p53, annexins (II, VI, XI), tropomyosin, caldesmon, calponin, lysozyme, calcyclin-binding protein/Siah-1-interacting protein, hop, sgt1, melusin, and kinesin light chain. However, the expression of S100A6 is regulated by DNA methylation, p53, nuclear transcription factor κB, platelet-derived growth factor, epidermal growth factor, tumor necrosis factor ·, retinoic acid, and some hormones (43). Further studies on the S100A6 detailed mechanism are clearly warranted.…”

Section: ------------------------------------------------------------mentioning

confidence: 99%

Decreased expression of S100A6 in oral squamous cell carcinoma

Zhong¹

2010

Oncol Rep

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Abstract.We previously established an in vitro cellular carcinogenesis model of oral squamous cell carcinoma (OSCC) with a line of human immortalized oral epithelia cells (HIOECs), a line of cancerous HB96 cells, and other cells (HB56 cells) at the early stage of carcinogenesis. In this study, comparative proteomic analysis identified a panel of differentially expressed proteins among these cells, and S100A6 was shown as one of the significantly downregulated proteins accompanying cellular transformation. S100A6 was further validated for its expression in the three cell lines and in the clinical samples of cancerous and paracancerous tissues from 30 primary OSCC patients. Western blot analysis and real-time PCR revealed the decreased S100A6 protein and mRNA levels in the cancerous HB56 and HB96 cells over HIOECs. Immunohistochemistry and real-time PCR also showed decreased S100A6 protein and mRNA levels in the cancerous tissues compared to the paracancerous tissues from OSCC patients. The results presented here suggest that the expression of S100A6 decreases along with the cancerization in OSCC both in vitro and in vivo.

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S100A6 – New facts and features

Cited by 138 publications

References 73 publications

Differential proteomic and phenotypic behaviour of papillary and anaplastic thyroid cell lines

Differential proteomic and phenotypic behaviour of papillary and anaplastic thyroid cell lines

MALDI Imaging Identifies Prognostic Seven-Protein Signature of Novel Tissue Markers in Intestinal-Type Gastric Cancer

Decreased expression of S100A6 in oral squamous cell carcinoma

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