S-100 dendritic cells in normal and Dermatobia hominis infested cattle skin

Oliveira-Sequeira, T.C.G.; Bachi, Carlos Eduardo; Lello, Edy de

doi:10.1590/s1413-95962000000400007

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“…However, the localization of bovine DCs in the pharynx, tonsils, and lymph nodes has not been fully characterized. Recently, the bovine dendritic cells in skin have been immunohistochemically stained with S-100 antibody (Oliveira-Sequeira et al, 2000). Also, it has been noted that the S-100 antibody is able to specifically stain only DCs rather than the macrophages in the lymph node and other tissues (Yamate et al, 2000;Madjid et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Distribution of S-100 positive dendritic cells in bovine pharynx, tonsils, and retropharyngeal lymph nodes

Wang

Bian

Shi

et al. 2008

Front. Agric. China

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Dendritic cells (DCs) are professional antigenpresenting cells. However, the distribution of bovine DCs in the pharynx, tonsil, and retropharyngeal lymph nodes has not yet been documented. To address this issue, immunohistochemistry was conducted using S-100 protein as a marker for DCs. It was observed that S-100 positive Langerhans cells (LCs) were primarily found in the basal layer of the pharyngeal epithelium. Some DCs were found in the outer layer of the epithelium and their dendrites extended out towards the epithelial surface. In the tonsil, S-100 positive DCs were found either in follicular germinal centers or in the T-cell areas. It is worth noting that the S-100 positive DCs were not only distributed in the cortex, but also in the medulla of bovine retropharyngeal lymph nodes. The distribution patterns of bovine DCs in the pharynx, tonsil, and retropharyngeal lymph nodes have an important implication for our understanding of the interaction between pathogens and host.

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Section: Introductionmentioning

confidence: 99%