Ryanodine Receptors/Calcium Release channels in Heart Failure and Sudden Cardiac Death

Common Variants in TRDN and CALM1 Are Associated with Risk of Sudden Cardiac Death in Chronic Heart Failure Patients in Chinese Han Population

“…Westaway et al reported three CASQ2 SNPs (rs17500488, rs3010396, and rs7366407) associated with SCD in patients with ICM[ 8 ]. All these results revealed that variants in RyR2 and its regulators play an essential role in the occurrence of SCD, which in agreement with previous hypothesis[ 18 , 19 ].…”

Common Variants in TRDN and CALM1 Are Associated with Risk of Sudden Cardiac Death in Chronic Heart Failure Patients in Chinese Han Population

“…Westaway et al reported three CASQ2 SNPs (rs17500488, rs3010396, and rs7366407) associated with SCD in patients with ICM[ 8 ]. All these results revealed that variants in RyR2 and its regulators play an essential role in the occurrence of SCD, which in agreement with previous hypothesis[ 18 , 19 ].…”

Conditional FKBP12.6 Overexpression in Mouse Cardiac Myocytes Prevents Triggered Ventricular Tachycardia Through Specific Alterations in Excitation- Contraction Coupling

“…4 The marked reduction in Ca 2ϩ spark frequency, which we report here in myocytes isolated from DT mice, is consistent with this hypothesis. Our results indeed show that FKBP12.6 overexpression is associated with a decreased occurrence of spontaneous openings of RYR2.…”

Exercise Training and Caloric Restriction Prevent Reduction in Cardiac Ca 2+ -Handling Protein Profile in Obese Rats

“…21 In addition, some investigators report that RyR phosphorylation increases Ca 2ϩ release from the sarcoplasmic reticulum to cytoplasm. 22 Thus, it is reasonable to expect that the improvement in phosphoThr 17 -PLN and phospho-Ser 2808 -RyR expressions plays a role in the prevention of left ventricular systolic reduction in the present study. The mechanisms underlying the increase in the phospho-Thr 17 -PLN and phospho-Ser 2808 -RyR expressions are out of the scope of our study.…”

Common Variants in TRDN and CALM1 Are Associated with Risk of Sudden Cardiac Death in Chronic Heart Failure Patients in Chinese Han Population

“…Westaway et al reported three CASQ2 SNPs (rs17500488, rs3010396, and rs7366407) associated with SCD in patients with ICM[ 8 ]. All these results revealed that variants in RyR2 and its regulators play an essential role in the occurrence of SCD, which in agreement with previous hypothesis[ 18 , 19 ].…”

Conditional FKBP12.6 Overexpression in Mouse Cardiac Myocytes Prevents Triggered Ventricular Tachycardia Through Specific Alterations in Excitation- Contraction Coupling

“…4 The marked reduction in Ca 2ϩ spark frequency, which we report here in myocytes isolated from DT mice, is consistent with this hypothesis. Our results indeed show that FKBP12.6 overexpression is associated with a decreased occurrence of spontaneous openings of RYR2.…”

Exercise Training and Caloric Restriction Prevent Reduction in Cardiac Ca 2+ -Handling Protein Profile in Obese Rats

“…21 In addition, some investigators report that RyR phosphorylation increases Ca 2ϩ release from the sarcoplasmic reticulum to cytoplasm. 22 Thus, it is reasonable to expect that the improvement in phosphoThr 17 -PLN and phospho-Ser 2808 -RyR expressions plays a role in the prevention of left ventricular systolic reduction in the present study. The mechanisms underlying the increase in the phospho-Thr 17 -PLN and phospho-Ser 2808 -RyR expressions are out of the scope of our study.…”

Common Variants in TRDN and CALM1 Are Associated with Risk of Sudden Cardiac Death in Chronic Heart Failure Patients in Chinese Han Population

“…Westaway et al reported three CASQ2 SNPs (rs17500488, rs3010396, and rs7366407) associated with SCD in patients with ICM[ 8 ]. All these results revealed that variants in RyR2 and its regulators play an essential role in the occurrence of SCD, which in agreement with previous hypothesis[ 18 , 19 ].…”

Conditional FKBP12.6 Overexpression in Mouse Cardiac Myocytes Prevents Triggered Ventricular Tachycardia Through Specific Alterations in Excitation- Contraction Coupling

“…4 The marked reduction in Ca 2ϩ spark frequency, which we report here in myocytes isolated from DT mice, is consistent with this hypothesis. Our results indeed show that FKBP12.6 overexpression is associated with a decreased occurrence of spontaneous openings of RYR2.…”

Exercise Training and Caloric Restriction Prevent Reduction in Cardiac Ca 2+ -Handling Protein Profile in Obese Rats

“…21 In addition, some investigators report that RyR phosphorylation increases Ca 2ϩ release from the sarcoplasmic reticulum to cytoplasm. 22 Thus, it is reasonable to expect that the improvement in phosphoThr 17 -PLN and phospho-Ser 2808 -RyR expressions plays a role in the prevention of left ventricular systolic reduction in the present study. The mechanisms underlying the increase in the phospho-Thr 17 -PLN and phospho-Ser 2808 -RyR expressions are out of the scope of our study.…”