Russian federal clinical guidelines on the diagnostics, treatment, and prevention of osteoporosis

Афанасьевна, Мельниченко Галина; Евгеньевна, Белая Жанна; Яковлевна, Рожинская Людмила; Владимировна, Торопцова Наталья; Ивановна, Алексеева Людмила; Валерьевна, Бирюкова Елена; Алексеевна, Гребенникова Татьяна; Константиновна, Дзеранова Лариса; Васильевич, Древаль Александр; Васильевич, Загородний Николай; Викторович, Ильин Александр; Викторовна, Крюкова Ирина; Михайловна, Лесняк Ольга; Октаевна, Мамедова Елизавета; Анатольевна, Никитинская Оксана; Александровна, Пигарова Екатерина; Семеновна, Родионова Светлана; Анатольевна, Скрипникова Ирина; Викторовна, Тарбаева Наталья; Яковлевич, Фарба Леонид; Тамерланович, Цориев Тимур; Олеговна, Чернова Татьяна; Владимировна, Юренева Светлана; Владимировна, Якушевская Оксана; Иванович, Дедов Иван

doi:10.14341/probl2017636392-426

Cited by 86 publications

(72 citation statements)

References 142 publications

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“…Несмотря на все преимущества данного метода диагностики, DXA не позволяет оценить костный объем и структуру костной ткани, а также -провести дифференциальную диагностику и установить причину снижения костной массы, поскольку низкие значения МПК могут наблюдаться и при остеопорозе, и при остеомаляции. Таким образом, в случае впервые выявленного остеопороза по результатам DXA необходимо проведение дифференциальной диагностики и исключение других метаболических заболеваний скелета, при которых снижение МПК и/или низкотравматичные переломы являются основным проявлением [66].…”

Section: инструментальная диагностика остеомаляцииunclassified

Osteomalacia in practice of endocrinologist: etiology, pathogenesis, differential diagnosis with osteoporosis

Golounina¹,

Рунова²,

Fadeyev³

2020

Osteopor Bone Dis

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Osteoporosis is the most common cause of low bone mineral density (BMD) and low-traumatic fractures in adults. However, differential diagnosis should also consider other causes of decreased BMD, including osteomalacia, as treatment for these conditions vary significantly. Osteomalacia is a systemic disorder characterized by decrease in bone strength due to of excessive accumulation of non-mineralized osteoid and uncoupling between bone matrix formation and mineralization. Osteomalacia in adults mostly develops due to severe vitamin D deficiency of any etiology, less often along with kidney pathology, mesenchymal tumors secreting fibroblast growth factor 23 or hereditary metabolic bone diseases. Clinical symptoms of osteomalacia are nonspecific and mostly manifest by generalized diffuse bone pain, muscle weakness, skeletal deformities and often go unnoticed at initial stage of the disease. Histomorphometric examination is the most accurate method of the diagnosis, which allows assessment of bone formation rate and calcification. The utmost priority of the treatment of osteomalacia of any etiology is the elimination of vitamin D deficiency, hypocalcemia, hypophosphatemia and prevention of bone deformities progression and muscle hypotension.

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Section: инструментальная диагностика остеомаляцииunclassified

Osteomalacia in practice of endocrinologist: etiology, pathogenesis, differential diagnosis with osteoporosis

Golounina¹,

Рунова²,

Fadeyev³

2020

Osteopor Bone Dis

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“…При проведении ДРа большое значение имеет оценка точности измерений, поскольку проекционная МПК и рассчитанный Т-критерий лежат в основе диагностики остеопороза, согласно клиническим рекомендациям по остеопорозу [5]. Рекомендуемый производителем метод автосегментирования области интереса обусловлен требованиями минимизации времени сканирования и снижения влияния оператора на результаты измерения.…”

Section: Discussionunclassified

“…Согласно рекомендациям International Society for clinical Densitometry и Министерства здравоохранения Российской Федерации, диагноз остеопороза обосновывается снижением минеральной плотности кости (МПК) в любой из трех зон центральной денситометрии (позвоночник l1-l4, шейка бедренной кости, весь проксимальный отдел бедренной кости) более чем на 2,5 средних квадратичных отклонения (СКО) относительно средних значений для населения в возрасте 20-30 лет, т.е. остеопорозу соответствует Т-критерий менее 2,5 СКО [3,5].…”

Section: Introductionunclassified

Assessment the Accuracy of Densitometry Measurements Using DMA PP2 Phantom

Петряйкин

Смолярчук

Петряйкин

et al. 2019

Traumatology and Orthopedics of Russia

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Purpose of the study — to assess the accuracy of dual energy x-ray absorptiometry (DXA ) for measurements of mineral bone density, bone mineral content, area of selected spine zone of examination as well as impact of subcutaneous fat layer and correction of auto-segmenting of the spine on the mentioned parameters. Material and Methods. The study was performed on iDXA scanner using the designed phantom DMA PP2 of the lumber spine with inlays to simulate subcutaneous fat (SF). To ensure correct assessment of measurements (precision and accuracy) the authors performed fivefold repeated scanning. Two modifications of the phantom were used, with and without SF inlays, as well as two methods for selection of spine range for examination – automatic and correction of autosegmentation. Results. Scanning of the phantom without SF inlays demonstrated a systematic understated values of bone mineral density (BMD) and bone mineral content (BMC) along the full measured interval: mean relative error of BMD for L1-L4 interval was 10.62% with automatic segmentation and 7.43% — with correction of autosegmentation. The least accuracy for BMD and BMC (1.53% and 0.90%, respectively) was observed during SF simulation and with correction of auto-segmentation of the spine. Analysis of variation coefficient for area of examined vertebrae, BMC and BMD demonstrated rather high precision of measurements, namely for BMD without SF in the L1-L4 interval amounted to 1.00% (auto-segmentation) and 0.56% (correction). Variation coefficient for scanning including SF inlays in the interval L1-L4 was 1.00% (auto-segmentation) and 0.68% (correction). Conclusion. The lowest level of accuracy was observed with the SFL object; in this case, the variation coefficient did not exceed 1% for all BMD interval. The mean value of the BMC accuracy also did not exceed 1% with the optimal scan parameters. The study proved the effectiveness of “RSK PK2” phantom when estimating the accuracy of BMD and BMC on iDXA scanner.

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“…Однако, в настоящее время мало сведений о результатах его применения при НО [12]. Терипаратид представляет собой анаболический препарат, который стимулирует костеобразование за счет прямого влияния на остеобласты, и так же, как и вышеперечислен-ные препараты, зарегистрирован для лечения постменопа-узального остеопороза [13]. В клиническом исследовании использования терипаратида у 79 взрослых пациентов с НО показана его эффективность для повышения МПК [14].…”

Section: Discussionunclassified

Rare genetic diseases of the bone tissue: the case of a family with osteogenesis imperfecta and X-linked hypophosphataemia

Popova

Юрьевна²,

Grebennikova

et al. 2018

Osteopor Bone Dis

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Osteogenesis imperfecta (OI) and X-linked hypophosphataemia (XLH) are rare genetic diseases, which lead to childhood-onset bone fragility, low-trauma fractures and limb deformities. OI occurs as a result of impaired type 1 collagen synthesis at different stages, depending on the type of a genetic mutation, which leads to bone strength impairment. In most cases OI is a disorder with an autosomal dominant inheritance. However, there are also cases of autosomal recessive inheritance. To date, 16 types of OI are distinguished, with type 2 being the most severe due to 100% mortality rate in neonatal and perinatal periods. XLH is characterized by altered bone mineralization due to impaired phosphorus absorption and reabsorption, as a result of mutations in the PHEX gene. The bone tissue «softens», and this process is accompanied by deformities in long tubular bones. In this article we describe the family, in which both diseases are presented, despite their rarity. The case is investigated from points of view: the clinician’s and the patient’s perspective.

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Russian federal clinical guidelines on the diagnostics, treatment, and prevention of osteoporosis

Cited by 86 publications

References 142 publications

Osteomalacia in practice of endocrinologist: etiology, pathogenesis, differential diagnosis with osteoporosis

Osteomalacia in practice of endocrinologist: etiology, pathogenesis, differential diagnosis with osteoporosis

Assessment the Accuracy of Densitometry Measurements Using DMA PP2 Phantom

Rare genetic diseases of the bone tissue: the case of a family with osteogenesis imperfecta and X-linked hypophosphataemia

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