Rumination, cognition, and the brain

Borders, Ashley

doi:10.1016/b978-0-12-812545-8.00009-7

Cited by 7 publications

(13 citation statements)

References 113 publications

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“…The CEN is also responsible for decision-making and problem solving in the pursuit of goal-directed behavior ( 41 ). The CEN is mainly anchored in the dorsolateral prefrontal cortex, the ventrolateral prefrontal cortex, the dorsomedial prefrontal cortex, and the lateral posterior parietal cortex ( 40 , 53 , 54 ).…”

Section: Brain Network and Functional Connectivity In Chronic Fatiguementioning

confidence: 99%

Chronic Fatigue in Cancer, Brain Connectivity and Reluctance to Engage in Physical Activity: A Mini-Review

2021

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A large amount of evidence shows that after a cancer diagnosis, patients significantly reduce their level of physical activity. Usually, this reduction is attributed to cancer-related fatigue. However, to our knowledge, no study has clearly demonstrated that fatigue alters effort-based decision-making in cancer. This mini-review aimed to provide evidence that chronic fatigue in cancer patients causes changes in brain connectivity that impact effort-based decision-making. Indeed, three patterns of activation to compensate for dysfunctional networks have been reported: greater variability in the executive network and hyperactivation in the executive network, which account for less efficient and costly processes in the frontal cortex, and reduced deactivation in the default mode network. Nevertheless, these activation patterns are also observed with other factors, such as anticipatory stressors (worry, rumination or sleep loss), that might also cause reluctance to engage in physical activity. Effort-based decision-making involving weighing costs against benefits and physical activity interventions should increase immediate benefits to facilitate engagement in effortful activities.

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Section: Brain Network and Functional Connectivity In Chronic Fatiguementioning

confidence: 99%

Chronic Fatigue in Cancer, Brain Connectivity and Reluctance to Engage in Physical Activity: A Mini-Review

2021

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“…The nodes of the CEN include the dorsolateral prefrontal cortex and the lateral posterior parietal cortex. The study of CEN is helpful for the monitoring of brain network in MCI patients ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

A Triple-Network Dynamic Connection Study in Alzheimer's Disease

Meng

Liang

et al. 2022

Front. Psychiatry

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Alzheimer's disease (AD) was associated with abnormal organization and function of large-scale brain networks. We applied group independent component analysis (Group ICA) to construct the triple-network consisting of the saliency network (SN), the central executive network (CEN), and the default mode network (DMN) in 25 AD, 60 mild cognitive impairment (MCI) and 60 cognitively normal (CN) subjects. To explore the dynamic functional network connectivity (dFNC), we investigated dynamic time-varying triple-network interactions in subjects using Group ICA analysis based on k-means clustering (GDA-k-means). The mean of brain state-specific network interaction indices (meanNII) in the three groups (AD, MCI, CN) showed significant differences by ANOVA analysis. To verify the robustness of the findings, a support vector machine (SVM) was taken meanNII, gender and age as features to classify. This method obtained accuracy values of 95, 94, and 77% when classifying AD vs. CN, AD vs. MCI, and MCI vs. CN, respectively. In our work, the findings demonstrated that the dynamic characteristics of functional interactions of the triple-networks contributed to studying the underlying pathophysiology of AD. It provided strong evidence for dysregulation of brain dynamics of AD.

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“…The dlPFC serves a primary role in regulating emotion (Underwood et al, 2021) and handles content in working memory and evaluates possible behavioural responses. The CEN also includes the lateral posterior parietal cortex (lPPC), which integrates sensory and interoceptive information to facilitate sustained attention (Borders, 2020). CEN functions are associated with mental health in various cognitive disorders.…”

Section: Introductionmentioning

confidence: 99%

“…However, links between CEN activity and behaviour are suggested to be task and context-dependent (Borders, 2020). For example, reduced dlPFC was associated with reduced rumination observed in healthy adults (Cooney et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, reduced CEN activity has been associated with chronic schizophrenia and depression (Leptourgos et al, 2020; Menon, 2011). However, links between CEN activity and behaviour are suggested to be task and context-dependent (Borders, 2020). For example, reduced dlPFC was associated with reduced rumination observed in healthy adults (Cooney et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Effective connectivity of emotion and cognition under psilocybin

Stoliker

Novelli

Vollenweider

et al. 2022

Preprint

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Classic psychedelics alter sense of self and patterns of self-related thought. These changes are hypothesised to underlie their therapeutic efficacy across internalising pathologies such as addiction, anxiety, and depression. Using resting-state functional MRI images from a randomised, double blinded, placebo-controlled clinical trial of 24 healthy adults under 0.215mg/kg psilocybin, we investigated the effective connectivity changes between the amygdala and the default mode network (DMN), salience network (SN) and central executive network (CEN). This connectivity underpins the appraisal and regulation of emotion and is associated with clinical symptomatology. We observed a general pattern of decreased top-down effective connectivity from the resting state networks of interest to the amygdala and directed connectivity changes associated with altered emotion and meaning under psilocybin. Our findings identify cognitive-emotional connectivity associated with the subjective effects of psilocybin and the attenuation of the amygdala as a potential biomarker of psilocybin's therapeutic efficacy.

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Rumination, cognition, and the brain

Cited by 7 publications

References 113 publications

Chronic Fatigue in Cancer, Brain Connectivity and Reluctance to Engage in Physical Activity: A Mini-Review

Chronic Fatigue in Cancer, Brain Connectivity and Reluctance to Engage in Physical Activity: A Mini-Review

A Triple-Network Dynamic Connection Study in Alzheimer's Disease

Effective connectivity of emotion and cognition under psilocybin

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