2010
DOI: 10.1007/978-3-642-11712-1_6
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Abstract: Transcriptional attenuation at E.coli's tryptophan operon is a prime example of RNA-mediated gene regulation. In this paper, we present a discrete stochastic model for this phenomenon based on chemical reactions. Our model is compact and intelligible, due to n-ary reactions (which preclude object-centric approaches) and to rule schemas that define finite sets of chemical reactions. Stochastic simulations with our model confirm results that were previously obtained by master equations or differential equations.… Show more

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Cited by 4 publications
(1 citation statement)
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References 39 publications
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“…The general syntax follows the notation of chemical reaction equations and the majority of other rule-based modeling languages, e.g. [ 8 , 9 , 16 , 17 , 25 ], namely reactants are written on the left-hand side and products on the right-hand side of an intermediate right-headed arrow:…”
Section: Resultsmentioning
confidence: 99%
“…The general syntax follows the notation of chemical reaction equations and the majority of other rule-based modeling languages, e.g. [ 8 , 9 , 16 , 17 , 25 ], namely reactants are written on the left-hand side and products on the right-hand side of an intermediate right-headed arrow:…”
Section: Resultsmentioning
confidence: 99%