Rubella-associated arthritis. I. Comparative study of joint manifestations associated with natural rubella infection and RA 27/3 rubella immunisation.

Tingle, Aubrey J.; Allen, Marilyn; Petty, Ross E.; Kettyls, G. D.; Chantler, J. K.

doi:10.1136/ard.45.2.110

Cited by 127 publications

(51 citation statements)

References 15 publications

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“…The criteria for finding causation-in-fact in the Special Master's Order state that a petitioner must have 1) received rubella vaccine at age 18 years or older, 2) no history of persistent or recurrent joint symptoms for at least 3 years prior to the rubella vaccination, 3) experienced the onset of arthritis symptoms between 1 and 6 weeks after the vaccination (this criterion was adopted by the Special Master based on clinical studies and expert testimony [6,7]) 4) developed an antibody response to rubella virus as determined by a commercial or standard laboratory assay (e.g., hemagglutinationinhibition assay, enzyme-linked immunosorbent assay, immunofluorescent antibody assay, etc.) 5 ) polyarticular symptoms lasting at least 6 months (or, if symptoms remitted after the acute stage, they recurred within 1 year of such remission), and 6) an absence of another good explanation for the arthropathy.…”

Section: Methodsmentioning

confidence: 99%

Chronic arthropathy and musculoskeletal symptoms associated with rubella vaccines. A review of 124 claims submitted to the national vaccine injury compensation program

Weibel

Benor

1996

Arthritis & Rheumatism

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Objective. To report the outcome of 124 claims of chronic arthropathy associated with rubella vaccine submitted to the National Vaccine Injury Compensation Program.Methods. Medical records and testimony were reviewed separately by physicians and Special Masters to determine the clinical diagnosis and eligibility for compensation under the Program.Results. Among the 124 subjects with chronic arthropathy, the onset occurred between 1 week and 6 weeks after the rubella vaccination in 72, and <1 week or >6 weeks after the vaccination in 52. Various conditions developed in the 2 onset groups (1-6 weeks postvaccination, < 1 week or >6 weeks postvaccination), including, respectively, unspecified arthritis (n = 29, n = I), specified arthritis (n = 11, n = 19), arthralgia (n = 24, n = 7), fibromyalgia (n = 4, n = ll), and multiple symptoms with minimal arthralgia or myalgia (n = 4, n = 14). Concordance of medical recommendations by Program physicians and Special Masters' decisions in 56 completed claims was 91%, with awards mainly to patients with chronic unspecified arthritis and arthralgia.Conclusion. The Program and the US Court of Federal Claims have accepted a causal relationship between currently used rubella vaccine in the US and some chronic arthropathy with an onset between 1 week and 6 weeks after vaccine administration.

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Section: Methodsmentioning

confidence: 99%

Chronic arthropathy and musculoskeletal symptoms associated with rubella vaccines. A review of 124 claims submitted to the national vaccine injury compensation program

Weibel

Benor

1996

Arthritis & Rheumatism

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“…On rare occasions, such vaccinees reportedly have developed chronic or recurrent arthralgias, sometimes with arthritis or neurologic symptoms, including paraesthesias, carpal tunnel syndrome, and blurred vision [14]. One group of investigators in Canada has reported that the incidence of persistent or recurrent frank arthritis following rubella vaccination is as high as 5-11 % in small studies of adult female vaccinees [15,16]. This rate is higher than the background annual rate of chronic arthritis in adult women due to all causes; data from the National Health Interview Survey conducted by the National Center for Health Statistics, CDC, indicate that 2 % of persons younger than age 34 years and 11 % of persons aged 35-44 years have consulted a physician within the last year for arthritis [17].…”

Section: Side Effects and Adverse Reactions To Rubella Vaccinationmentioning

confidence: 99%

Rubella in the United States: toward a strategy for disease control and elimination

Herrmann

1991

Epidemiol. Infect.

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More than 25 years have passed since the last rubella epidemic in the United States. The rubella pandemic of 1964–5 demonstrated clearly the extraordinary teratogenic potential of the rubella virus. In the United States alone, it is estimated that more than 12500000 cases of rubella occurred during the winter and spring of 1964–5. Congenital rubella infection occurred in an estimated 30000 pregnancies, 10000 resulting in fetal death or therapeutic abortion and 20000 resulting in infants born with congenital rubella syndrome (CRS) [1]. In contrast, during 1988, only 225 cases of rubella were reported to the Centers for Disease Control (CDC) in Atlanta, the lowest annual total since rubella became a nationally notifiable disease in 1966 [2]. However, in 1989, this downward trend of reported cases was interrupted, with the number of reported rubella cases in the United States increasing nearly twofold, and in 1990, the total increased another threefold (to more than 1000 cases) [3]. Although the 1990 reports represent the highest total since 1982, the overall incidence of rubella in the United States has still declined by more than 98% since 1969, the year rubella vaccine was licensed (Fig. 1).

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“…Joint symptoms, which may occur in up to 52 % adult women with naturallyacquired rubella [37], are less frequent and less severe following immunization. The peripheral joints, i.e.…”

Section: Adverse Reactionsmentioning

confidence: 99%

“…Overall, joint symptoms lasting 7 days or more were seen in 5 of 136 (3 7 %) vaccinees. Tingle and his colleagues [37] reported recurrent arthropathy for longer than 18 months in 2 of 44 adult females given RA27/3. Joint reactions with HPV77-derived vaccines tend to be more severe.…”

Section: Adverse Reactionsmentioning

confidence: 99%

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Rubella vaccines: past, present and future

Best

1991

Epidemiol. Infect.

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The association between rubella in pregnancy and congenital anomalies was first reported 50 years ago, by N. McAlister Gregg, an Australian ophthalmologist [1]. During the next 20 years his findings were confirmed by others (reviewed in [2]). However, the first reports of the isolation of rubella virus in cell cultures and development of tests for neutralizing antibodies were not published until 1962 [3, 4]. Subsequent studies conducted in the UK and North America during a pandemic of rubella in 1963–4, were therefore able to make a more accurate estimate of the risks of maternal rubella at different stages of pregnancy. It was estimated that about 30000 rubella-damaged babies were born in the USA alone in 1963–4 [5]. This emphasized the importance of developing a vaccine to prevent infection in pregnancy and thereby, the birth of babies with rubella-induced congenital defects.

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Rubella-associated arthritis. I. Comparative study of joint manifestations associated with natural rubella infection and RA 27/3 rubella immunisation.

Cited by 127 publications

References 15 publications

Chronic arthropathy and musculoskeletal symptoms associated with rubella vaccines. A review of 124 claims submitted to the national vaccine injury compensation program

Chronic arthropathy and musculoskeletal symptoms associated with rubella vaccines. A review of 124 claims submitted to the national vaccine injury compensation program

Rubella in the United States: toward a strategy for disease control and elimination

Rubella vaccines: past, present and future

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