RTOG, CTCAE and WHO criteria for acute radiation dermatitis correlate with cutaneous blood flow measurements

Huang, Chih-Jen; Hou, Ming‐Feng; Luo, Kuei-Hau; Wei, Shuyi; Huang, Ming‐Yii; Su, Suh-Jen; Kuo, Hsing‐Chun; Yuan, Shyng‐Shiou F.; Chen, Gwo‐Shing; Hu, Stephen Chu‐Sung; Chuang, Hung‐Yi

doi:10.1016/j.breast.2015.01.008

Cited by 63 publications

(63 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is routinely assessed by visual grading of severity, from 0 to 5, by using the US National Cancer Institute's Common Terminology Criteria for Adverse Events (CTCAE) v4.0 (http://ctep.cancer.gov). Other visual scores close to the CTCAE are the Radiation Therapy Oncology Group (RTOG) and World Health Organization (WHO) criteria …”

Section: Introductionmentioning

confidence: 99%

High‐frequency ultrasound quantification of acute radiation dermatitis: pilot study of patients undergoing radiotherapy for breast cancer

Garnier

Champeaux

Laurent

et al. 2017

Skin Research and Technology

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

High‐frequency ultrasound quantification of acute radiation dermatitis: pilot study of patients undergoing radiotherapy for breast cancer

Garnier

Champeaux

Laurent

et al. 2017

Skin Research and Technology

View full text Add to dashboard Cite

show abstract

“…We could recognize 5 stages by TLS (0‐4) and just 3 by CTCAE v4.0 (0‐2). The small number of categories separated by routinely use scales to describe skin condition was indicated as their main limitation also by other authors …”

Section: Discussionmentioning

confidence: 99%

“…They are usually assessed by semi‐quantitative clinical scores, like US National Cancer Institute's Common Terminology Criteria for Adverse Events (CTCAE) v4.0, Radiation Therapy Oncology Group (RTOG) or WHO criteria, which are not validated and may be subject to inter‐observer variability. Moreover, as abovementioned clinical scores provide just a few categories to described skin condition, their results are not precise . More accurate assessment could be done by histopathological examination of skin biopsy; however, it is not recommended because skin undergoing radiotherapy presents with impaired healing process.…”

Section: Introductionmentioning

confidence: 99%

An ultrasonographic monitoring of skin condition in patients receiving radiotherapy for head and neck cancers

et al. 2019

View full text Add to dashboard Cite

Radiodermatitis is one of the commonest side effects of radiotherapy. They are usually assessed by semi‐quantitative clinical scores, which are not validated and may be subject to inter‐observer variability. A few previous studies suggested that high‐frequency ultrasonography (HF‐USG) is useful in the assessment of the acute phase of radiation dermatitis in breast cancer patients. (a) To monitor skin changes by HF‐USG during the course of radiotherapy due to head and neck cancers, and (b) to determine whether there is any connection between skin sonograms and the skin scoring criteria. This prospective, observational study includes patients diagnosed with head and neck cancers, treated with radiotherapy or concomitant chemoradiation. The final analysis includes six patients. In every patient, the HF‐USG as well as dermatological assessment (target lesion score—TLS and CACE v. 4.0) were performed 4×: before, in the middle, day after, and 3 months after radiotherapy. There were significant differences between non‐irradiated skin thickness and thickness of skin with clinically obvious radiodermatitis (TLS grade 1‐4; P < .0001), as well as between irradiated, unchanged skin thickness (TLS grade 0) and thickness of skin with clinically obvious radiodermatitis (TLS grade 1‐4; P = .0002). There was no significant difference between non‐irradiated and irradiated, unchanged skin thickness (TLS grade 0; P = .9318). In four patients, we demonstrated subepidermal low echogenic band (SLEB). HF‐USG can be useful tool to noninvasive and objective assessment of skin changes during radiotherapy.

show abstract

“…RTOG standard for acute radiation mucositis and dermatitis were used for grading [6,7] (Table 1); G0…”

Section: Radiation Reaction and Criteriamentioning

confidence: 99%

Correlated factors of acute oral mucosal and skin reaction induced by radiotherapy in hypopharyngeal carcinoma

Wang¹,

Lu²,

Huang³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background This present retrospective single center study was intended to investigate the factors associated with acute radiation oral mucositis or dermatitis during hypopharyngeal carcinoma radiotherapy.Methods From May 2012 to December 2018, previously untreated 93 patients with hypopharyngeal squamous cell carcinoma received radiotherapy in Affiliated Cancer Hospital of Zhengzhou University were enrolled. Radiation Therapy Oncology Group (RTOG) scoring criteria were used for assessing the severity of toxicities. Patients are therefore classified into “mild reaction group” (G0~G1) and “acute reaction group” (G2~G4). Single variate was applied to screen out factors with significant difference between mild and acute reaction groups, multivariate analysis was used to detect independent risk factors from those related. A total of 16 medical and laboratory indexes were included to examine, i.e., gender, age, smoking history, primary site, history of hypotension and diabetes, treatment modalities, dose, T (tumor) staging, N (reginal lymph node) staging, as well as hemoglobin value (1 week before radiotherapy). Relevant data used for the study were collected from clinical records.Results Total of 93 subjects completed radiotherapy. Acute mucositis occurred in 75 patients, and 27 cases developed acute radiation dermatitis. Smoking history, post-operative radiotherapy, concurrent chemotherapy, T staging, N staging, total dose (Gy) for GTV, single fraction dose (Gy) for GTV, and hemoglobin value (1 week before radiotherapy) showed significant differences between G0~G1 and G2~G4 groups of oral mucosa reaction; significant differences between mild and acute dermatitis reaction groups were found in diabetes history, hemoglobin value, age, total dose (Gy). Multivariate analysis showed that higher hemoglobin value ( OR = 1.120, P = 0.031), smoking history ( OR = 0.070, P = 0.031) were independent risk factor of acute OM; significant relationships for acute skin reaction were found with hemoglobin value ( OR = 1.059, P = 0.034) and older age ( OR = 1.068, P = 0.036).Conclusion Multivariate analysis showed higher hemoglobin value and smoking history to be the most relevant factors independently predicting grades 2 or higher OM; higher hemoglobin value and older age were found to be significantly associated with acute skin reaction.

show abstract

RTOG, CTCAE and WHO criteria for acute radiation dermatitis correlate with cutaneous blood flow measurements

Cited by 63 publications

References 38 publications

High‐frequency ultrasound quantification of acute radiation dermatitis: pilot study of patients undergoing radiotherapy for breast cancer

High‐frequency ultrasound quantification of acute radiation dermatitis: pilot study of patients undergoing radiotherapy for breast cancer

An ultrasonographic monitoring of skin condition in patients receiving radiotherapy for head and neck cancers

Correlated factors of acute oral mucosal and skin reaction induced by radiotherapy in hypopharyngeal carcinoma

Contact Info

Product

Resources

About