2014
DOI: 10.1016/j.exger.2014.09.021
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Abstract: Royalactin is a glycoprotein essential for the development of long-lived queen honeybees. Only larvae fed with royal jelly, containing royalactin, develop into queens. Royalactin plays a central role in this process by switching on the epidermal growth factor (EGF) receptor signaling pathway which ultimately leads to epigenetic changes and a long-lived queen phenotype. Recently it was shown that royalactin by itself also extends lifespan in Drosophila melanogaster. Yet, the mechanism by which royalactin promot… Show more

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Cited by 37 publications
(48 citation statements)
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“…This EOR-1 dependence is consistent with our previous findings showing that royalactin-mediated longevity is reliant on EGF signaling. 34 Functional SKN-1 is seemingly not needed to increase gst-4 p -controlled GFP levels following royalactin treatment, whereas the increase in fluorescence levels is abolished in a mutant lacking functional EOR-1. This implies that EOR-1, but not SKN-1, is necessary for the royalactin-dependent transcription of gst-4.…”
Section: Eor-1 Mediates Royalactin's Beneficial Effects and Increasesmentioning
confidence: 98%
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“…This EOR-1 dependence is consistent with our previous findings showing that royalactin-mediated longevity is reliant on EGF signaling. 34 Functional SKN-1 is seemingly not needed to increase gst-4 p -controlled GFP levels following royalactin treatment, whereas the increase in fluorescence levels is abolished in a mutant lacking functional EOR-1. This implies that EOR-1, but not SKN-1, is necessary for the royalactin-dependent transcription of gst-4.…”
Section: Eor-1 Mediates Royalactin's Beneficial Effects and Increasesmentioning
confidence: 98%
“…34 The EGF pathway regulates longevity via maintaining protein homeostasis, largely independent of insulin/IGF-like signaling (IIS). 36 Here we pinpoint the EOR-1 protein, a BTB/zinc-finger transcription factor similar to mammalian promyelocytic leukemia zinc-finger protein (PLZF), as a mediator of royalactin's beneficial effects regarding resistance to exogenously applied oxidative stress in C. elegans.…”
Section: Eor-1 Mediates Royalactin's Beneficial Effects and Increasesmentioning
confidence: 99%
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