Royal jelly modulates oxidative stress and tissue injury in gamma irradiated male Wister Albino rats

Abstract

Background:Royal jelly is a nutritive secretion produced by the worker bees, rich in proteins, carbohydrates, vitamins and minerals.Aim:The present study was designed to determine the possible protective effects of royal jelly against radiation induced oxidative stress, hematological, biochemical and histological alterations in male Wister albino rats.Materials and Methods:Male Wister albino rats were exposed to a fractionated dose of gamma radiation (2 Gy every 3 days up to 8 Gy total doses). Royal jelly was administrated (g/Kg/day) by gavages 14 days before exposure to the 1st radiation fraction and the treatment was continued for 15 days after the 1st irradiation fraction till the end of the experiment. The rats were sacrificed 3rd, equivalent to 3rd post 2nd irradiation fraction, and equivalent to 3rd day post last irradiation fraction.Results:In the present study, gamma- irradiation induced hematological, biochemical and histological effects in male Wister albino rats. In royal jelly treated irradiated group, there was a noticeable decrease recorded in thiobarbituric reactive substances concentration when compared to γ-irradiated group. Also, the serum nitric oxide concentration was significantly improved. The administration of royal jelly to irradiated rats according to the current experimental design significantly ameliorates the changes induced in serum lipid profile. Moreover, in royal jelly treated irradiated group, there was a noticeable amelioration recorded in all hematological parameters along the three experimental intervals. The microscopic examination of cardiac muscle of royal jelly treated irradiated rats demonstrated structural amelioration, improved nuclei and normal features of capillaries and veins in endomysium when compared to gamma-irradiated rats.Conclusion:It was suggested that the biochemical, hematological and histological amelioration observed in royal jelly (g/Kg/day) treated irradiated rats might be due to the antioxidant capacity of royal jelly active constituents.

The Possible Protective Role of Bone Marrow Transplantation against Alternations Induced by Gamma Radiations on Heart of Pregnant Albino Rats and Their Fetuses

“…These results were also recorded by several authors (Ali and Haggag, 2006;Abdel Mottaal andAbdel Maguid, 2007, Bakhit, 2010 ;Azab et al 2011).…”

“…Abnormal structures of cardiac muscles were found as ill-defined shape, necrotic, pyknotic nuclei, sever dilated, widened and inflammated capillaries in endomysium ( Azab et al 2011). …”

Ameliorative Role of Bee Honey and Royal Jelly Against Cisplatin Induced Alteration in Hematological Parameters in Male Wister Albino Rat

“…The present study showed the improvement in the tested blood parameters as erythrocytes, hemoglobin, leukocytes, platelets and the mean value of packed cell volume (PCV), mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) indicates that honey and royal jelly administration prevented blood cell damage by maintaining the integrity of cells. Administration of royal jelly to rats ameliorated the effect of radiation that induced oxidative stress and hematological alterations [56].…”

“…Honey and royal jelly have a protective role against many drugs, wherever [55] the honey protective effects on organs through the improvement in the hematological parameters (RBCs, WBCs and Platelets) because of decreased lipopolysaccharide in rats. Honey is reported to attenuate the hematological, effects induced by gentamicin [56,45]. Natural honey significantly (P<0.05) restored Hb content, RBC, PCV, platelet and WBC close to control values in wistar albino rats fed hydrocarbon contaminated diets [57].…”

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“…RJ has been reported to modulate tissue injury and oxidative stress in rats. [13,14] A study has reported the antioxidant property of RJ by preparing enzyme hydrolysates which are having much higher antioxidant activity. [15] Further anti-inflammatory dose-dependent effect of RJ against formalin in rat hind paw was observed.…”