Royal Jelly Constituents Increase the Expression of Extracellular Superoxide Dismutase through Histone Acetylation in Monocytic THP-1 Cells

Makino, Junya; Ogasawara, Rie; Kamiya, Tetsuro; Hara, Hirokazu; Mitsugi, Yukari; Yamaguchi, Eiji; Itoh, Akichika; Adachi, Tetsuo

doi:10.1021/acs.jnatprod.6b00037

Cited by 40 publications

(34 citation statements)

References 44 publications

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“…10-HDA and 4-hydroperoxy-2-decenoic acid ethyl ester have been shown to inhibit histone deacetylase activity, thereby enhancing the expression of extracellular SOD release by leukemia THP-1 cells, and suggesting therapeutic potential against atherosclerosis (Makino et al, 2016). Histone deacetylase inhibition by 10-HDA is thought to reactivate the expression of epigenetically silenced genes in mammalian cells, leading to the hypothesis that a similar effect could be at the basis of caste switching in bees (Spannhoff et al, 2011).…”

Section: Royal Jellymentioning

confidence: 99%

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

et al. 2017

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Honeybees produce honey, royal jelly, propolis, bee venom, bee pollen, and beeswax, which potentially benefit to humans due to the bioactives in them. Clinical standardization of these products is hindered by chemical variability depending on honeybee and botanical sources, but different molecules have been isolated and pharmacologically characterized. Major honey bioactives include phenolics, methylglyoxal, royal jelly proteins (MRJPs), and oligosaccharides. In royal jelly there are antimicrobial jelleins and royalisin peptides, MRJPs, and hydroxy-decenoic acid derivatives, notably 10-hydroxy-2-decenoic acid (10-HDA), with antimicrobial, anti-inflammatory, immunomodulatory, neuromodulatory, metabolic syndrome preventing, and anti-aging activities. Propolis contains caffeic acid phenethyl ester and artepillin C, specific of Brazilian propolis, with antiviral, immunomodulatory, anti-inflammatory and anticancer effects. Bee venom consists of toxic peptides like pain-inducing melittin, SK channel blocking apamin, and allergenic phospholipase A2. Bee pollen is vitaminic, contains antioxidant and anti-inflammatory plant phenolics, as well as antiatherosclerotic, antidiabetic, and hypoglycemic flavonoids, unsaturated fatty acids, and sterols. Beeswax is widely used in cosmetics and makeup. Given the importance of drug discovery from natural sources, this review is aimed at providing an exhaustive screening of the bioactive compounds detected in honeybee products and of their curative or adverse biological effects.

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Section: Royal Jellymentioning

confidence: 99%

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

et al. 2017

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“…Promoter methylation regulates the expression and activity of other inflammatory cytokines implicated in AAA formation including TNF- α , IL-1 β , and monocyte chemotactic protein-1 (MCP-1 or CCL2) [150–154]. Likewise, reactive oxygen species (ROS) can increase histone acetylation via modulation of HAT activity to promote inflammation in several cell lines [155–157]. Hydrogen peroxide induces gene acetylation by increasing HAT activity and suppressing HDAC activity [158].…”

Section: Epigenetic Risk Factorsmentioning

confidence: 99%

Genetic and Epigenetic Regulation of Aortic Aneurysms

Kim

Stansfield

2017

BioMed Research International

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Aneurysms are characterized by structural deterioration of the vascular wall leading to progressive dilatation and, potentially, rupture of the aorta. While aortic aneurysms often remain clinically silent, the morbidity and mortality associated with aneurysm expansion and rupture are considerable. Over 13,000 deaths annually in the United States are attributable to aortic aneurysm rupture with less than 1 in 3 persons with aortic aneurysm rupture surviving to surgical intervention. Environmental and epidemiologic risk factors including smoking, male gender, hypertension, older age, dyslipidemia, atherosclerosis, and family history are highly associated with abdominal aortic aneurysms, while heritable genetic mutations are commonly associated with aneurysms of the thoracic aorta. Similar to other forms of cardiovascular disease, family history, genetic variation, and heritable mutations modify the risk of aortic aneurysm formation and provide mechanistic insight into the pathogenesis of human aortic aneurysms. This review will examine the relationship between heritable genetic and epigenetic influences on thoracic and abdominal aortic aneurysm formation and rupture.

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“…Chemical characteristics of FAs in RJ have been determined by gas chromatography-mass spectrometry (GC-MS), high performance liquid chromatography (HPLC), and ultraperformance liquid chromatography (UPLC) methods from lyophilized royal jelly [17–19]. Previous studies have investigated the ability of SEA to inhibit histone deacetylase [20] and modulate the estrogen receptor [21]. Both 10-H2DA and 10-HDAA have been shown to possess diverse pharmacological activities such as immunomodulatory [22], estrogenic [21, 23], and anti-inflammatory effects [24] in vitro .…”

Section: Introductionmentioning

confidence: 99%

In VitroAnti-Inflammatory Effects of Three Fatty Acids from Royal Jelly

Chen

Wang

Zhang

et al. 2016

Mediators of Inflammation

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Trans-10-hydroxy-2-decenoic acid (10-H2DA), 10-hydroxydecanoic acid (10-HDAA), and sebacic acid (SEA) are the three major fatty acids in royal jelly (RJ). Previous studies have revealed several pharmacological activities of 10-H2DA and 10-HDAA, although the anti-inflammatory effects and underlying mechanisms by which SEA acts are poorly understood. In the present study, we evaluated and compared the in vitro anti-inflammatory effects of these RJ fatty acids in lipopolysaccharide-stimulated RAW 264.7 macrophages. The results showed that 10-H2DA, 10-HDAA, and SEA had potent, dose-dependent inhibitory effects on the release of the major inflammatory-mediators, nitric oxide, and interleukin-10, and only SEA decreased TNF-α production. Several key inflammatory genes have also been modulated by these RJ fatty acids, with 10-H2DA showing distinct modulating effects as compared to the other two FAs. Furthermore, we found that these three FAs regulated several proteins involved in MAPK and NF-κB signaling pathways. Taken together, these findings provide additional references for using RJ against inflammatory diseases.

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Royal Jelly Constituents Increase the Expression of Extracellular Superoxide Dismutase through Histone Acetylation in Monocytic THP-1 Cells

Cited by 40 publications

References 44 publications

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

Genetic and Epigenetic Regulation of Aortic Aneurysms

In VitroAnti-Inflammatory Effects of Three Fatty Acids from Royal Jelly

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