Royal jelly attenuates gastric mucosal injury in a rat ethanol-induced gastric injury model

Duran, Yasin; Karaboğa, İhsan; Polat, Fatin Rüştü; Polat, Elif; Erboğa, Zeynep Fidanol; Ovalı, Mehmet Akif; Öztopuz, Özlem; Çelikkol, Aliye; Yılmaz, Ahsen

doi:10.1007/s11033-020-05939-w

Cited by 14 publications

(14 citation statements)

References 61 publications

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“…Unfortunately, owing to their significant side effects, such as gynecomastia, hypoacidity, impotence, osteoporotic bone fracture, hypergastrinemia, and cardiovascular disease risks, these medications are facing serious challenges [7][8][9]. Therefore, natural products with a broad range of biological actions, improved efficacy, and safety are required to replace chemical drugs [10,11].…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective effects of Combretum paniculatum (Combretaceae) leaf extract and fractions on absolute ethanol-induced gastric ulcer in rats

et al. 2022

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Background Combretum paniculatum (Combretaceae) Vent. is commonly used in traditional medicine to treat ulcers and gastrointestinal disorders, including distended spleens and the liver. This study investigated the gastroprotective effects of C. paniculatum leaf extract and its fractions on absolute ethanol-induced gastric ulcers in rats and explored their effects on endogenous antioxidant (SOD, MDA, GSH, and Catalase) levels. Butanol, n-hexane, and ethyl acetate extracts (100 and 200 mg/kg), omeprazole (20 mg/kg), and control (3% Tween 80) were administered orally. Results The methanolic extract and fractions of C. paniculatum exhibited varying degrees of ulcer protection. MECP exhibited significant (P < 0.05) ulcer protection (55.56%) at 200 mg/kg; at 100 and 200 mg/kg, HFCP induced considerable (P < 0.01 & 0.001) ulcer reduction (64.44% and 80.00%), respectively; EAFCP offered substantial (P < 0.05) ulcer reduction (57.78%) at 200 mg/kg, whereas BFCP produced significant (P < 0.01) ulcer protection (73.33% and 68.89%) at 100 and 200 mg/kg against absolute ethanol-induced ulcer. MDA levels were substantially reduced after pretreatment with the extract and fractions, whereas SOD, GSH, and catalase levels were significantly enhanced. Conclusion These findings suggest that C. paniculatum leaf extract and fractions possess gastroprotective actions against ethanol-induced ulcers and exert these effects through antioxidant mechanisms. Therefore, the traditional use of C. paniculatum leaves in the treatment of ulcers is justified.

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Section: Introductionmentioning

confidence: 99%

Gastroprotective effects of Combretum paniculatum (Combretaceae) leaf extract and fractions on absolute ethanol-induced gastric ulcer in rats

et al. 2022

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“…36 The high expression of IL-6 during inflammation may be an important cause of ethanol-induced gastric mucosal injury, 21 and IL-1⊎ contributes to the development of gastric mucosal injury by promoting the accumulation of neutrophils. 37 There was a negative correlation between grain consumption and the IL-6 level. 38 Quinoa is rich in anti-inflammatory phytochemicals, and so it has potential anti-inflammatory and protective effects.…”

Section: Discussionmentioning

confidence: 94%

“…It triggers cytotoxicity, apoptosis and acute‐phase responses in the pathological process, and is involved in the occurrence of inflammatory lesions and damage in gastric tissue 36 . The high expression of IL‐6 during inflammation may be an important cause of ethanol‐induced gastric mucosal injury, 21 and IL‐1 β contributes to the development of gastric mucosal injury by promoting the accumulation of neutrophils 37 . There was a negative correlation between grain consumption and the IL‐6 level 38 .…”

Section: Discussionmentioning

confidence: 99%

The protective effect of quinoa on the gastric mucosal injury induced by absolute ethanol

et al. 2022

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BACKGROUND: Gastric mucosal injury caused by ethanol is a common gastrointestinal disease. Quinoa (Chenopodium quinoa Willd.), as a nutrient-rich grain, plays a significant role in preventing and treating gastric mucosal damage. The present study aimed to explore the protective effect of quinoa on alcohol-induced gastric mucosal damage and its possible mechanism.RESULTS: The ethanol-induced gastric mucosal injury rat model was used for in vivo experiments and H 2 O 2 -induced GES-1 cells for in vitro experiments to elucidate the protective effect of quinoa. The results show that quinoa water extract can increase the superoxide dismutase level and decrease the malondialdehyde level in vitro and in vivo. Furthermore, quinoa also reduced the bleeding point and bleeding area in rats with ethanol-induced gastric mucosal injury and improved gastric histopathological changes. H 2 O 2 significantly increased the levels of inflammatory factors in GES-1 cells, which were markedly ameliorated by quinoa water extract. Likewise, quinoa water extract regulated the protein expression levels of Nrf2, Keap1, HO-1, p-IKK, and p-NF-κB through Nrf2 and nuclear factor-κB signaling pathways, reducing the production of oxidative stress and inflammation, thereby repairing the damaged gastric mucosa. CONCLUSION:The findings of this study demonstrated that quinoa shows protective effect against ethanol-induced gastric mucosal injury through its anti-inflammatory and anti-oxidant effects. We propose that our research will provide a reference for quinoa as a functional food.

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“…Based on previous studies, the gastric ulcer index has become an important indicator to assess treatment efficiency [19,20]. Previous studies suggest that the ulcer index of the stomach was decreased significantly through BGF pretreatment for seven days, providing direct evidence of BGF inhibited gastric injury.…”

Section: Discussionmentioning

confidence: 99%

Bruguiera gymnorrhiza (L.) Lam. Fruit Accelerates Healing in Gastric Injury via the Regulation of the NF-κB Pathway

Zhang

Mai

Gao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Context. Bruguiera gymnorrhiza (L.) Lam. (BG), as a major species of mangroves, is also a traditional Chinese medicine, which has received attention for its anti-inflammatory and anticancer effects. However, the protective effect of BG on gastric injury is rarely studied. Objective. The present study aimed at the anti-inflammatory and antioxidant effects of the extract of Bruguiera gymnorrhiza (L.) Lam. fruit (BGF) on the gastric injury. Materials and Methods. The chemical components in the extract of BGF were used in UPLC/Q-Orbitrap analysis. 60 SD rats were randomized into six groups: normal group (MC), ethanol-injured control group (EC), omeprazole group, and three groups with different doses (50, 100, and 200 mg/kg) of BGF. After continuous administration for seven days, the stomachs of rats were taken out to observe the pathological gastric tissue changes; inflammatory factors and oxidative stress markers in the stomach tissues were measured. Western blot (WB) analyses were conducted to explore the mechanism of BGF on gastric tissue and RAW 246.7 cells with excessive inflammation. Results. BGF enhanced gastric mucosal protection by improving the mucosal blood flow of the stomach and significantly decreased inflammatory factors and oxidative stress markers. Moreover, BGF significantly reduced the expression of p-NF-κB p65. Consistently, BGF demonstrated similar effects on LPS-induced RAW 264.7 cells as it did in vivo. Conclusion. BGF could accelerate the healing of gastric injury by exerting antioxidant and anti-inflammatory effects and maintaining mucosal integrity.

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Royal jelly attenuates gastric mucosal injury in a rat ethanol-induced gastric injury model

Cited by 14 publications

References 61 publications

Gastroprotective effects of Combretum paniculatum (Combretaceae) leaf extract and fractions on absolute ethanol-induced gastric ulcer in rats

Gastroprotective effects of Combretum paniculatum (Combretaceae) leaf extract and fractions on absolute ethanol-induced gastric ulcer in rats

The protective effect of quinoa on the gastric mucosal injury induced by absolute ethanol

Bruguiera gymnorrhiza (L.) Lam. Fruit Accelerates Healing in Gastric Injury via the Regulation of the NF-κB Pathway

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