Routine tests reveal unknown strains of BSE prions

Willerroider, Marika

doi:10.1038/425648a

Nature

2003

DOI: 10.1038/425648a

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Routine tests reveal unknown strains of BSE prions

Marika Willerroider¹

Abstract: Physician launches public protest over medical Nobel Routine tests reveal unknown strains of BSE prions Visual aid: Raymond Damadian built this magnetic resonance imaging machine, dubbed Indomitable, in 1977.

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Raman Analysis of Prion Protein in Blood Cell Membranes from Naturally Affected Scrapie Sheep

Carmona

Monleón²,

Monzón³

et al. 2004

Chemistry & Biology

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At present, there are no efficient antemortem diagnostic tests for transmissible spongiform encephalopathys (TSEs), particularly in blood. New strains of prion PrPSc, which causes TSEs, are currently appearing, and researchers remain concerned that if prion variants continue to emerge, some of them may escape detection by existing immunoassay tests. Because a common structural feature of PrPSc strains is their high content of beta sheets, Raman spectroscopy has proven to be a suitable technique to analyze a key membranous fraction of blood containing PrPSc. In this fraction, a significant increase in beta sheets has been correlated with the worsening of this TSE in naturally scrapie-infected animals in comparison with healthy controls. Since sensitivity and specificity were found to be 100% for each, this test may lead to a new and alternative diagnosis for prion diseases.

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Raman Analysis of Prion Protein in Blood Cell Membranes from Naturally Affected Scrapie Sheep

Carmona

Monleón²,

Monzón³

et al. 2004

Chemistry & Biology

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show abstract

Risks and implications of bovine spongiform encephalopathy for the United States: insights from other countries

Fox

Peterson

2004

Food Policy

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BSE has not been found in the US * but current detection efforts provide little assurance that it does not exist at a low level. The US has taken precautionary measures to reduce the risk of importing the disease and the risk of the disease spreading if it were to be found. Those measures include a ban on feeding ruminant protein to ruminants-a measure the General Accounting Office concluded was not adequately enforced and which failed to halt the disease in the UK. We present an overview of BSE in the UK, the EU, and Japan and present an argument for additional precautionary measures in the US.

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Russian claims first in magnetic imaging

MacWilliams¹

2003

Nature

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Routine tests reveal unknown strains of BSE prions

Abstract: Physician launches public protest over medical Nobel Routine tests reveal unknown strains of BSE prions Visual aid: Raymond Damadian built this magnetic resonance imaging machine, dubbed Indomitable, in 1977.

Cited by 4 publications

References 0 publications

Raman Analysis of Prion Protein in Blood Cell Membranes from Naturally Affected Scrapie Sheep

Raman Analysis of Prion Protein in Blood Cell Membranes from Naturally Affected Scrapie Sheep

Risks and implications of bovine spongiform encephalopathy for the United States: insights from other countries

Russian claims first in magnetic imaging

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