“…The antimicrobial characteristics and bactericidal mechanism of various series of QACs (Csiba et al, 1987;Devinsky et al, 1991;Kourai et al, 1994b;Krysinski, 1990), including the derivatives of pyridinium salts (Devinsky et al, 1996;Kourai et al, 1994c;Krysinski, 1991;Okazaki et al, 1997aOkazaki et al, , 1997c, have been studied. The hydrophobicity of QACs (Kourai et al, 1995), the critical micelle concentration (Pavlikova-Moricka et al, 1994), and acidic dissociation constant (pKa) of the corresponding pyridines (Kourai et al, 1985) were measured to determine a quantitative structure-activity relationship.…”