2018
DOI: 10.1001/jamapediatrics.2018.1960
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Abstract: This analysis of data from the Global Burden of Disease Study examines the extent of rotavirus infection and associated deaths among children younger than 5 years worldwide and whether the rotavirus vaccine has reduced the diarrhea-associated mortality.

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Cited by 567 publications
(515 citation statements)
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References 23 publications
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“…Rotavirus A (RVA) is the major viral agent causing acute diarrhea in immunocompetent children <5 years . RVA belongs to the Reoviridae family, nonenveloped multilayered virion, with 11‐segmented double‐stranded RNA (dsRNA).…”
Section: Introductionmentioning
confidence: 99%
“…Rotavirus A (RVA) is the major viral agent causing acute diarrhea in immunocompetent children <5 years . RVA belongs to the Reoviridae family, nonenveloped multilayered virion, with 11‐segmented double‐stranded RNA (dsRNA).…”
Section: Introductionmentioning
confidence: 99%
“…Next, we measured changes in cytosolic Ca 2+ by determining the relative GCaMP5G fluorescence (F/F 0 ) for the whole field-of-view (FOV) (∼455 µm 2 ) for three replicate infections and time lapse images were acquired once per minute (Fig. 1C).…”
Section: Resultsmentioning
confidence: 99%
“…Rotavirus (RV), a member of the Reoviridae family, is one of the first viruses shown to elevate cellular Ca 2+ levels and has become a widely-used model system to characterize mechanisms by which viruses dysregulate host Ca 2+ homeostasis 1 . RV is a clinically important enteric virus that causes severe diarrhea and vomiting in children, resulting in over approximately 258 million diarrhea episodes and 198,000 deaths in 2016 2 . Hyperactivation of cyclic nucleotide ( e.g ., cAMP/cGMP) and Ca 2+ signaling pathways is a common strategy among enteric pathogens 3 .…”
Section: Introductionmentioning
confidence: 99%
“…Rotaviruses are a major cause of acute gastroenteritis in children under 5 years of age worldwide and rotavirus infections are responsible of approximately 128.000 deaths per year 13 . The prevalence is similar in developed and developing countries, but the majority of deaths occur in developing countries, where rotavirus vaccines are not available or are less efficient than in developed countries 14 .…”
Section: Discussionmentioning
confidence: 99%