Rotavirus Surveillance in Urban and Rural Areas of Niger, April 2010–March 2012

Page, Anne‐Laure; Jusot, Viviane; Mamaty, Abdoul-Aziz; Lagaré, Adamou; Kaplon, Jérôme; Pothier, Pierre; Djibo, Ali; Manzo, M; Touré, Brahima; Langendorf, Céline; Collard, Jean-Marc; Grais, RFebecca F

doi:10.3201/eid2004.131328

Cited by 30 publications

(30 citation statements)

References 25 publications

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“…In this study, RVA genotype G12P[8] was the prevalent genotype, corroborating previous reports conducted in Asian, European, American, and African continents, demonstrating the epidemiological relevance of this genotype worldwide [Cunliffe et al, ; Page et al, ; Potgieter et al, ; Jere et al, ; Page et al, ; Seheri et al, ; Bucardo et al, ; Luchs et al, ]. The high proportion of genotype G12 in African populations is believed to be associated with the emergence of genotype P[6] [Steele and Ivanoff, ; Page et al, ; Seheri et al, ].…”

Section: Discussionsupporting

confidence: 88%

“…The preliminary data from these countries showed that RVA vaccines were safe and effective in protecting children from severe diarrhea caused by RVA. However, the impact of regionally prevalent and mixed genotypes on vaccine effectiveness in Africa is not yet clear, and needs to be monitored [Madhi et al, ; Cunliffe et al, ; Groome et al, ; Page et al, ; Bar‐Zeev et al, ].…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology of rotavirus A diarrhea in Chókwè, Southern Mozambique, from February to September, 2011

Langa

Thompson²,

Arnaldo³

et al. 2016

Journal of Medical Virology

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Acute diarrhea disease caused by Rotaviruses A (RVA) is still the leading cause of morbidity and mortality in children ≤5 years old in developing countries. An exploratory cross-sectional study was conducted between February and September, 2011 to determine the proportion of acute diarrhea caused by RVA. A total of 254 stool specimens were collected from children ≤5 years old with acute diarrhea, including outpatients (222 children) and inpatients (32 children), in three local health centers in Chókwè District, Gaza Province, South of Mozambique. RVA antigens were detected using enzyme immunoassay (EIA); the RVA G (VP7) and P (VP4) genotypes were determined by RT-PCR or analysis sequencing. Sixty (24%) out of 254 fecal specimens were positive for RVA by EIA; being 58 (97%) from children ≤2 years of age. RVA prevalence peaks in June and July (coldest and drier months) and the G[P] binary combination observed were G12P[8] (57%); G1P[8] (9%); G12P[6] (6%); and 2% for each of the following genotypes: G1P[6], G2P[6] G4P[6], and G9P[8]. Non-Typeable (NT) G and/or P genotypes were observed as follows: G12P [NT] (6%); G1P [NT], G3P[NT] and GNTP[NT] (4%). Considering the different GP combinations, G12 represented 67% of the genotypes. This is the first data showing the diversity of RVA genotypes in Mozambique highlighting the epidemiological importance of these viruses in acute diarrhea cases in children ≤2 years old. In addition, these findings will provide a baseline data before the introduction of the RVA monovalent (Rotarix(®) ) vaccine in the National Immunization Program in September 2015. J. Med. Virol. 88:1751-1758, 2016. © 2016 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Epidemiology of rotavirus A diarrhea in Chókwè, Southern Mozambique, from February to September, 2011

Langa

Thompson²,

Arnaldo³

et al. 2016

Journal of Medical Virology

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“…G12 RVA are considered emerging human RVA strains, and the lineage III G12 allele has spread worldwide rapidly [18, 19]. Strain G12P[8] was associated with a large outbreak of pediatric gastroenteritis in Rochester in 2007 (an outbreak detected through the NSVN) [13], and this genotype has been reported recently in Niger [20], Spain [21], Nicaragua [22], Haiti [23], and Australia [24]. It appears that G12P[8] strains now are established in the United States.…”

Section: Discussionmentioning

confidence: 99%

Rotavirus Strain Trends During the Postlicensure Vaccine Era: United States, 2008–2013

Bowen

Mijatovic-Rustempasic

Esona

et al. 2016

J Infect Dis.

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Background Group A rotaviruses (RVA) are a significant cause of pediatric gastroenteritis worldwide. The New Vaccine Surveillance Network (NVSN) has conducted active surveillance for RVA at pediatric hospitals and emergency departments at 3–7 geographically diverse sites in the United States since 2006. Methods Over 6 consecutive years, from 2008 to 2013, 1523 samples from NVSN sites that were tested positive by a Rotaclone enzyme immunoassay were submitted to the Centers for Disease Control and Prevention for genotyping. Results In the 2009, 2010, and 2011 seasons, genotype G3P[8] was the predominant genotype throughout the network, with a 46%–84% prevalence. In the 2012 season, G12P[8] replaced G3P[8] as the most common genotype, with a 70% prevalence, and this trend persisted in 2013 (68.0% prevalence). Vaccine (RotaTeq; Rotarix) strains were detected in 0.6%–3.4% of genotyped samples each season. Uncommon and unusual strains (eg, G8P[4], G3P[24], G2P[8], G3P[4], G3P[6], G24P[14], G4P[6], and G9P[4]) were detected sporadically over the study period. Year, study site, and race were found to be significant predictors of genotype. Conclusions Continued active surveillance is needed to monitor RVA genotypes in the United States and to detect potential changes since vaccine licensure.

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“…Similarly, in our study, G2P [4] proved to be the second-most prevalent genotype circulating in the south of the country where the study was conducted. However, in Niger and the Democratic Republic of Congo, G2P [4] was the predominant genotype before vaccine introduction [24,25]. However, G2P [4] was found circulating in the Central Africa Republic at a rate of 13%, in Cameroon at 5.9%, Burkina Faso at <1% and Gabon at <2% [26][27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Molecular Characteristics of Rotavirus Genotypes Circulating in the South of Benin, 2016-2018

Agbla

Esona²,

Agbankpé

et al. 2020

Preprint

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ObjectiveRotavirus remains the main causative agent of gastroenteritis in young children in countries that have not yet introduced the vaccine. In Benin, rotavirus vaccine was introduced late December 2019 into the EPI. This study aims to provide pre-vaccination era rotavirus genotyping data in Benin. These data can supplement data from the surveillance system of Ministry of Health of Benin which is supported by the World Health Organization (WHO). ResultsOf the 420 diarrheal stool samples, actively collected in southern Benin from July 2016 through November 2018 from children under five years old and suffering from gastroenteritis, 167 (39.8%) samples were rotavirus EIA positive. 186 (44.3%) samples contained amplifiable rotavirus RNA detected by qRT-PCR method and were genotyped using one-step RT-PCR multiplex genotyping method. G1P[8] represents the predominant genotype (32%) followed by the G2P[4] (26%), G3P[6] (16%), G12P[8] (13%) and mixed G and P types (1%). Four samples (2%) could not be assigned both G and P type speciﬁcity.

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Rotavirus Surveillance in Urban and Rural Areas of Niger, April 2010–March 2012

Cited by 30 publications

References 25 publications

Epidemiology of rotavirus A diarrhea in Chókwè, Southern Mozambique, from February to September, 2011

Epidemiology of rotavirus A diarrhea in Chókwè, Southern Mozambique, from February to September, 2011

Rotavirus Strain Trends During the Postlicensure Vaccine Era: United States, 2008–2013

Molecular Characteristics of Rotavirus Genotypes Circulating in the South of Benin, 2016-2018

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