Rotavirus G12 in Spain: 2004–2006

Cilla, Gustavo; Montes, Milagrosa; Arana, Ainara

doi:10.1016/j.eimc.2014.01.012

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…G5, G8 and G10 have been identified recently in different parts of the world, including India, Ghana, Australia, Argentina, Paraguay and Malawi (Hoshino, Jones, Ross, & Kapikian, ). Recently, the G12 genotypes have been re‐emerged in humans in the United States (Wylie, Stanley, Tekippe, Mihindukulasuriya, & Storch, ), Spain (Cilla, Montes, & Arana, ) and Tunisia (Moussa et al, ). The remarkable diversity of human RVA strains is associated with three major evolutionary mechanisms: the accumulation of point mutations leading to antigenic drift; reassortment of cognate genome segments promoting antigenic shift; and the reassortment of genes in strains found in animals that could introduce new antigen types into humans (Martella, Bányai, Matthijnssens, Buonavoglia, & Ciarlet, ; Matthijnssens et al, ).…”

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Molecular characterization of group A rotavirus from rhesus macaques ( Macaca mulatta ) at human–wildlife interfaces in Bangladesh

Islam

Hossain

Haider

et al. 2019

Transbound Emerg Dis

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Group A rotavirus (RVA) is an important cause of diarrhoea in people, especially children, and animals globally. Due to the segmented nature of the RVA genome, animal RVA strains have the potential to adapt to the human host through reassortment with other co‐infecting human viruses. Macaques share food and habitat with people, resulting in close interaction between these two species. This study aimed to detect and characterize RVA in rhesus macaques (Macaca mulatta) in Bangladesh. Faecal samples (N = 454) were collected from apparently healthy rhesus macaques from nine different sites in Bangladesh between February and March 2013. The samples were tested by one‐step, real‐time, reverse transcriptase‐polymerase chain reaction (PCR). Four percent of samples (n = 20; 95% CI 2.7%–6.7%) were positive for RVA. RVA positive samples were further characterized by nucleotide sequence analysis of two structural protein gene fragments, VP4 (P genotype) and VP7 (G genotype). G3, G10, P[3] and P[15] genotypes were identified and were associated as G3P[3], G3P[15] and G10P[15]. The phylogenetic relationship between macaque RVA strains from this study and previously reported human strains indicates possible transmission between humans and macaques in Bangladesh. To our knowledge, this is the first report of detection and characterization of rotaviruses in rhesus macaques in Bangladesh. These data will not only aid in identifying viral sharing between macaques, human and other animals, but will also improve the development of mitigation measures for the prevention of future rotavirus outbreaks.

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confidence: 99%

mentioning

confidence: 99%

Molecular characterization of group A rotavirus from rhesus macaques ( Macaca mulatta ) at human–wildlife interfaces in Bangladesh

Islam

Hossain

Haider

et al. 2019

Transbound Emerg Dis

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Community Based Case-Control Study of Rotavirus Gastroenteritis among Young Children during 2008-2010 Reveals Vast Genetic Diversity and Increased Prevalence of G9 Strains in Kolkata

et al. 2014

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BackgroundGroup A Rotaviruses are a major etiologic agent of gastroenteritis in infants and young children (<5 years) worldwide. Although rotavirus vaccines have been successfully administered in many countries, in India the introduction of rotavirus vaccine in national immunization program was approved in 2014. Since high disease burden and large number of genetic variants have been reported from low income countries including India, monitoring of rotavirus was initiated prior to implementation of the vaccine in the region.MethodsA total number of 3,582 stool samples were collected from an urban slum community in Kolkata, among which 1,568 samples were obtained from children of ≤5 years of age, with moderate to severe diarrhoea and 2,014 samples were collected from age-sex matched healthy neighbourhood controls. Rotavirus positive samples were typed by multiplex semi-nested PCR and nucleotide sequencing. Circulating strains were phylogenetically analyzed.ResultsAmong 1,568 children with diarrhoea, 395 (25.2%), and among 2,014 asymptomatic children, 42 (2%) were rotavirus positive. G1P[8] was identified as the most common strain (32%) followed by G9P[8] (16.9%), G2P[4] (13.5%) and G9P[4] (10.75%). G12 strains with combinations of P[4], P[6] and P[8] comprised 11.9% of total positive strains. The rest (<10%) were rare and uncommon strains like G1P[4], G1P[6], G2P[8] and animal-like strains G4P[6], G6P[14] and G11P[25]. The 42 rotavirus positive samples from asymptomatic children revealed common genotypes like G1, G2 and G9.ConclusionThis community based case-control study showed increased predominance of genotype G9 in Kolkata. It also confirmed co-circulation of a large number of genetic variants in the community. Asymptomatic rotavirus positive children though low in number can also be a source of dispersal of infection in the community. This study provides background information to the policy makers for implementation of rotavirus vaccines in this region.

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Rotavirus G12 in Spain: 2004–2006

Cited by 2 publications

References 9 publications

Molecular characterization of group A rotavirus from rhesus macaques ( Macaca mulatta ) at human–wildlife interfaces in Bangladesh

Molecular characterization of group A rotavirus from rhesus macaques ( Macaca mulatta ) at human–wildlife interfaces in Bangladesh

Community Based Case-Control Study of Rotavirus Gastroenteritis among Young Children during 2008-2010 Reveals Vast Genetic Diversity and Increased Prevalence of G9 Strains in Kolkata

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