Rotator Cuff Repair Augmentation in a Canine Model with Use of a Woven Poly-L-Lactide Device

Derwin, Kathleen A.; Codsi, Michael J.; Milks, Ryan; Baker, Andrew R.; McCarron, Jesse A.; Iannotti, Joseph P.

doi:10.2106/jbjs.h.00775

Cited by 143 publications

(137 citation statements)

References 62 publications

(87 reference statements)

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“…GraftJacket 1 has been studied extensively in terms of rotator cuff repair augmentation. When compared to other graft materials, GraftJacket 1 reportedly had a higher load-to-failure than Permacol 1 , TissueMend 1 , Restore 1 , and CuffPatch 1 but is notably weaker than autologous tendon [15].…”

Section: Ecm Augmentationmentioning

confidence: 88%

“…[54]. Another similar study demonstrated TissueMend 1 had higher levels of DNA embedded in the ECM when compared to other xenograft materials [15]. No additional studies have been performed using these xenografts in rotator cuff repair.…”

Section: Ecm Augmentationmentioning

confidence: 97%

“…A third study using polylactic acid patches in goats showed no observable difference between the treated and control groups [37]. Derwin et al [15] performed a similar experiment using a woven poly-L-lactide device. The superior 2 .…”

Section: Ecm Augmentationmentioning

confidence: 99%

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Strategies in Biologic Augmentation of Rotator Cuff Repair: A Review

Cheung

Silverio

Sperling

2010

Clinical Orthopaedics &Amp; Related Research

146

103

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Background Degenerative rotator cuff tears are increasing with the aging population, and healing is not uniform after surgery. Rotator cuffs may show improved healing when biologic factors are added during surgery. Questions/purposes We asked: (1) What cellular processes are involved in normal bone-to-tendon healing? (2) What approaches are being developed in tendon augmentation? (3) What approaches are being developed with the addition of growth factors? Methods We reviewed research in relating to biologic augmentation and cellular processes involved in rotator cuff repair, focusing on animal models of rotator cuff repair and nonrandomized human trials. Results Regular bone-to-tendon healing forms a fibrous junction between tendon and bone that is distinct from the original bone-to-tendon junction. Tendon augmentation with cellular components serves as scaffolding for fibroblastic cells and a possible source of growth factors and fibroblastic cells. Extracellular matrices provide a scaffold for incoming fibroblastic cells, although current research does not conclusively confirm which if any of these scaffolds enhance repair owing in part to intermanufacturer variations and the limited human research. Growth factors and platelet-rich-plasma are established in other fields of research and may enhance repair but have not been rigorously tested. Conclusions There is potential application of biologic augmentation to improve healing after rotator cuff repair. However, research in this field is still inconclusive and has not been sufficiently demonstrated to merit regular clinical use. Future human trials can elucidate the use of biologic augmentation in rotator cuff repairs.

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Section: Ecm Augmentationmentioning

confidence: 88%

Section: Ecm Augmentationmentioning

confidence: 97%

See 1 more Smart Citation

Strategies in Biologic Augmentation of Rotator Cuff Repair: A Review

Cheung

Silverio

Sperling

2010

Clinical Orthopaedics &Amp; Related Research

146

103

View full text Add to dashboard Cite

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“…3 of the tendon width [17]. One shoulder underwent tendon release and repair only, and the contralateral shoulder was subjected to release and repair followed by augmentation with a reinforced (human) fascia patch.…”

Section: Methodsmentioning

confidence: 99%

“…In addition, seven pairs of canine cadaver shoulders underwent infraspinatus injury and repair with and without augmentation and served as Time 0 biomechanical controls. Historical biomechanical data from eight unpaired, canine cadaver shoulders were referenced as normal controls [17]. The study received prior approval of our Institutional Animal Care and Use Committee.…”

Section: Methodsmentioning

confidence: 99%