Rotating magnetic field induced oscillation of magnetic particles for in vivo mechanical destruction of malignant glioma

Cheng, Yu; Muroski, Megan E.; Petit, D.; Mansell, Rhodri; Vemulkar, Tarun; Morshed, Ramin A.; Han, Yu; Balyasnikova, Irina V.; Horbinski, Craig; Huang, Xinlei; Zhang, Lingjiao; Cowburn, R. P.; Lesniak, Maciej S.

doi:10.1016/j.jconrel.2015.12.028

Cited by 127 publications

(121 citation statements)

References 33 publications

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“…Compared to the micro-scale magnetic materials, nanomaterials are easily internalized by cells 39, and the intracellular cell membrane destruction has been proven to be more efficient than the disruption from the cell surface 23. Furthermore, the magnetic field in this study is safe and its frequency substantially lower than the risk level in adults 40.…”

Section: Introductionmentioning

confidence: 84%

Elongated Nanoparticle Aggregates in Cancer Cells for Mechanical Destruction with Low Frequency Rotating Magnetic Field

Shen

Uyeda

et al. 2017

Theranostics

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Magnetic nanoparticles (MNPs) functionalized with targeting moieties can recognize specific cell components and induce mechanical actuation under magnetic field. Their size is adequate for reaching tumors and targeting cancer cells. However, due to the nanometric size, the force generated by MNPs is smaller than the force required for largely disrupting key components of cells. Here, we show the magnetic assembly process of the nanoparticles inside the cells, to form elongated aggregates with the size required to produce elevated mechanical forces. We synthesized iron oxide nanoparticles doped with zinc, to obtain high magnetization, and functionalized with the epidermal growth factor (EGF) peptide for targeting cancer cells. Under a low frequency rotating magnetic field at 15 Hz and 40 mT, the internalized EGF-MNPs formed elongated aggregates and generated hundreds of pN to dramatically damage the plasma and lysosomal membranes. The physical disruption, including leakage of lysosomal hydrolases into the cytosol, led to programmed cell death and necrosis. Our work provides a novel strategy of designing magnetic nanomedicines for mechanical destruction of cancer cells.

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Section: Introductionmentioning

confidence: 84%

Elongated Nanoparticle Aggregates in Cancer Cells for Mechanical Destruction with Low Frequency Rotating Magnetic Field

Shen

Uyeda

et al. 2017

Theranostics

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“…Although MNPs represent an area of active development for MHT, the in vivo anti-tumor effect under a low-frequency magnetic field using MNPs has not yet been demonstrated. A study by Cheng et al (94) demonstrated the successful use of spin-vortex, disk-shaped permalloy magnetic particles in a low-frequency, rotating magnetic field for the in vitro and in vivo destruction of glioma cells. In addition, the hysteresis loss is also important for MHT, as increasing the hysteresis loss is improving the heating efficiency (94).…”

Section: Cancer Treatmentmentioning

confidence: 99%

“…A study by Cheng et al (94) demonstrated the successful use of spin-vortex, disk-shaped permalloy magnetic particles in a low-frequency, rotating magnetic field for the in vitro and in vivo destruction of glioma cells. In addition, the hysteresis loss is also important for MHT, as increasing the hysteresis loss is improving the heating efficiency (94). A study by Sasayama et al (95) examined the hysteresis loss of magnetically fractionated MNPs for hyperthermia application.…”

Section: Cancer Treatmentmentioning

confidence: 99%

Magnetic nanoparticles in cancer diagnosis, drug delivery and treatment (Review)

2017

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Abstract. In recent years, magnetic nanoparticles (MNPs) have demonstrated marked progress in the field of oncology. General nanoparticles are widely used in tumor targeting, and the intrinsic magnetic property of MNPs makes them the most promising nanomaterial to be used as contrast agents for magnetic resonance imaging (MRI) and induced magnetic hyperthermia. The properties of MNPs are fully exploited when they are used as drug delivery agents, wherein drugs may be targeted to the desired specific location in vivo by application of an external magnetic field. Early diagnosis of cancer may be achieved by MRI, therefore, individualized treatment may be combined with MRI, so as to achieve the precise definition and appropriate treatment. In the present review, research on MNPs in cancer diagnosis, drug delivery and treatment has been summarized. Furthermore, the future perspectives and challenges of MNPs in the field of oncology are also discussed. IntroductionMagnetic nanoparticles (MNPs) are a kind of intelligent nanomagnetic material, with small particle size, large specific surface area, magnetic response and superparamagnetism (1). MNPs may be assembled and positioned under a constant magnetic field, and the heat is absorbed by the electromagnetic wave in the alternating magnetic field. In biomedical applications, MNPs are generally in the superparamagnetic state (2,3). The most frequently used nanomaterial is the iron oxide nanoparticle, including magnetite (Fe 3 O 4 ) and maghemite (γ-Fe 2 O 3 ) (4). It is well known that MNPs have an important role in cancer diagnosis, drug delivery and treatment. For cancer diagnosis, tumor imaging technology opened the possibility of early detection of disease. Common imaging modalities include magnetic resonance imaging (MRI) (5), magneto acoustic tomography (MAT) (6), computed tomography (CT) (7) and near-infrared (NIR) imaging (8). Among them, MRI has a strong influence in the early diagnosis of cancer, and superparamagnetic iron oxide nanoparticles (SPIONs) are the most representative as a contrast agent for MRI (9). Currently, certain iron oxide-based MNPs have been approved for use in clinical MRI, for example ferumoxil (GastroMARK) enhances imaging of the bowel (10). Due to the small size and large specific surface area of MNPs, they are able to easily reach the location of the lesion (11). Therefore, MNPs as a drug carrier for drug delivery is an application that cannot be ignored. This property of MNPs is fully exploited when they are used as drug delivery agents, wherein drugs may be targeted to the desired specific location in vivo by application of an external magnetic field (12). In general, MNPs are used as drug carriers by binding antibodies (13) and chemotherapeutic drugs (14). Commonly, chemotherapeutic drugs are loaded in MNPs, and they are involved in cancer treatment. MNPs in the field of cancer therapy are generally used in several different ways: Chemotherapy; magnetic hyperthermia (MHT) (15); photodynamic therapy (PDT) (16); and photothermal ther...

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“…They also speculated that the mechanical oscillation of microdiscs attached to the cancercell membrane may be transformed into an ionic electrical signal, which triggers the programmed cell-death pathway. Cheng et al demonstrated that a low frequency (20 Hz), rotating magnetic field could induce the rotating of spinvortex, disk-shaped permalloy magnetic particles, creating enough mechanical force that can destruct cell membrane of glioma cells [43]. A swing magnetic field with low frequency and low heat-production was designed by Chen et al in order to evaluate the torque effect of magnetotactic bacteria on S. aureus (Figures 2(a) and 2(b)) [44].…”

Section: Under Constant or Low Frequency Magnetic Fieldmentioning

confidence: 99%

Mechanisms of Cellular Effects Directly Induced by Magnetic Nanoparticles under Magnetic Fields

Chen

Wang

et al. 2017

Journal of Nanomaterials

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The interaction of magnetic nanoparticles (MNPs) with various magnetic fields could directly induce cellular effects. Many scattered investigations have got involved in these cellular effects, analyzed their relative mechanisms, and extended their biomedical uses in magnetic hyperthermia and cell regulation. This review reports these cellular effects and their important applications in biomedical area. More importantly, we highlight the underlying mechanisms behind these direct cellular effects in the review from the thermal energy and mechanical force. Recently, some physical analyses showed that the mechanisms of heat and mechanical force in cellular effects are controversial. Although the physical principle plays an important role in these cellular effects, some chemical reactions such as free radical reaction also existed in the interaction of MNPs with magnetic fields, which provides the possible explanation for the current controversy. It is anticipated that the review here could provide readers with a deeper understanding of mechanisms of how MNPs contribute to the direct cellular effects and thus their biomedical applications under various magnetic fields.

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Rotating magnetic field induced oscillation of magnetic particles for in vivo mechanical destruction of malignant glioma

Cited by 127 publications

References 33 publications

Elongated Nanoparticle Aggregates in Cancer Cells for Mechanical Destruction with Low Frequency Rotating Magnetic Field

Elongated Nanoparticle Aggregates in Cancer Cells for Mechanical Destruction with Low Frequency Rotating Magnetic Field

Magnetic nanoparticles in cancer diagnosis, drug delivery and treatment (Review)

Mechanisms of Cellular Effects Directly Induced by Magnetic Nanoparticles under Magnetic Fields

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