Abstract:The results of this study show that ciprofibrate and rosuvastatin or a combination of both can be considered an effective, safe and well-tolerated lipid-lowering treatment for patients with AIDS on highly active antiretroviral therapy.
“…Domingos et al  also stated that there was a predominance of patients on HAART therapy containing PI. Caramelli et al  pointed out that, after the introduction of HAART containing PI, a remarkable increase in triglycerides and total cholesterol and a slight decrease in HDL-C were observed.…”
Cardiovascular events due to decompensated lipid metabolism are commonly found in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) patients using anti-retroviral therapy (HAART). Thus, the aim of this study was to identify the effect of a bioactive food compound (BFC) containing functional foods on individuals with HIV undergoing HAART. Particularly, this study aims to verify the clinical outcome in the change of the lipid profile due to the use of this compound. This study includes 115 individuals with HIV on HAART. All patients received dietary guidelines; however, sixty-one consumed BFC while fifty-one did not (NO BFC). Biochemical examinations and socio-demographic and clinical profiles were evaluated. As result, in patients using hypolipidemic and/or hypoglycemic drugs, there was 28.6% decrease in triglyceride levels (p < 0.001) in the NO BFC group, and 18.3% reduction in low density lipoprotein cholesterol (LDL-C) (p < 0.001) in the BFC group. In patients who did not use hypolipidemic and/or hypoglycemic drugs in the NO BFC group, there was 30.6% increase in triglycerides, 11.3% total cholesterol and 15.3% LDL-C levels (p < 0.001) while for the BFC group there was 4.5% reduction in total cholesterol (p < 0.001). In conclusion, this study evidenced that the dietary intervention containing BFC positively affected in lipid control, since these HIV/AIDS patients using HAART are more vulnerable to lipid disorders.
“…Para o terceiro grupo, dos pacientes HIV positivos, Domingos et al 14 orientam o uso do ciprofibrato, da rosuvastatina ou da combinação de ambos, sendo efetivo, seguro e bem tolerado nos indivíduos com infecção pelo HIV.…”
Introdução: O estudo aqui apresentado fundamenta-se na associação de drogas para controle da dislipidemia em crianças, diabéticos, HIV-positivos e idosos. Objetivo: Discorrer acerca das dislipidemias sob o panorama dos fármacos de melhor escolha fazendo um paralelo entre os achados bibliográficos quanto a eficiência entre as principais drogas utilizadas no tratamento das dislipidemias. Material e Método: O presente estudo trata-se de levantamento bibliográfico sobre o tema através de achados de artigos científicos e demais materiais técnico-científicos. Resultados e Conclusão: Em crianças pode-se indicar a droga Ezetimibe como alternativa de vanguarda para o tratamento das mesmas, de forma que existem contraindicações neste grupo principalmente do ácido nicotínico ou fibratos, ficando ainda as estatinas como uma droga de primeira escolha. Para pacientes diabéticos contra indica-se o ácido nicotínico e sequestrantes de ácido biliar, visto que ambos alteram o índice glicêmico. Indica-se nestes casos os moduladores SRAA e as estatinas de intensidade moderada. Em Idosos verificou-se que as estatinas compreendem o tratamento de primeira escolha para reduzir os níveis de LDL (Lipoproteína de Baixa Densidade) e produzir pequenos aumentos de HDL (Lipoproteína de Alta Densidade) com declínio modesto em TG (Triglicérides), reduzindo a probabilidade de doenças cardiovasculares. Lembrando que é aceitável nos estudos selecionados a associação de um fibrato a uma estatina. E por fim os pacientes HIV – positivos, notou-se que o uso do ciprofibrato, da rosuvastatina ou da combinação de ambos, sendo efetivo, seguro, e bem tolerado por estes indivíduos.Descritores: Dislipidemias; Terapêutica; Complicações do Diabetes; Criança; Idoso; Soropositividade para HIV.
“…Dyslipidaemia may worsen the situation of patients receiving HAART since it has been found to be associated with increased cardiovascular events (7,(33)(34)(35). It is reported that up to 81.5% of patients on HAART for at least 12 months develop dyslipidaemia (36).…”
“…The latest data presented by the Joint United Nations Program on HIV (UNAIDS), in 2008, showed an increase in the number of people infected in Latin America and Brazil. 3 More recent data from the Brazilian Ministry of Health (2017) found that the number of people over 65 of age with HIV rose by 103% in the last 10 years.…”
Section: Changes In the Nutritional Status Of Elderly Patients With H...mentioning
Introduction: Acquired immunodeficiency syndrome (AIDS) is an infectious contagious disease produced by the human immunodeficiency virus (HIV) that causes progressive immunosuppression, making individuals susceptible to infections and opportunistic diseases. Despite its benefits, antiretroviral therapy has side effects, such as insulin resistance, dyslipidemia, high blood pressure and increased risk of cardiovascular disease. Objective: The aim of this study was to identify metabolic alterations in elderly patients with AIDS who use antiretroviral therapy (ART). Methods: The study consisted of a retrospective bibliographic review, including indexed articles published over the last 10 years, written in Portuguese and English, which evaluated changes in nutritional status and metabolic changes in HIV-positive patients who used ART. Results: According to the Brazilian Ministry of Health, the number of people over 65 with HIV grew by 103% in the last decade. The HIV virus has a long incubation period before the onset of the first symptoms of the disease, which results in AIDS. Dyslipidemia affects approximately 70% of HIV-infected patients who use ART, and occurs due to an increase in serum cholesterol, triglycerides and/or a reduction in HDL-cholesterol. Conclusion: The WHO recommends that nutritional interventions form part of HIV/AIDS control and treatment programs since they improve treatment adherence and ART effectiveness. In this context, a healthy diet that is adequate for the needs of the individual contributes to increased levels of CD4 T lymphocytes and reduces the harm caused by opportunistic infections, while improving intestinal absorption, as well as decreasing muscle loss and lipodystrophy syndrome, whose symptoms can significantly reduce the survival rates of patients.Keywords: HIV; AIDS; ART; Lipodystrophy syndrome (LS); Dyslipidemia; Insulin resistance.
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